2,670 research outputs found
Biomarkers of Oxidative Stress and Endogenous Antioxidants for Patients with Chronic Subjective Dizziness
As a neurotologic disorder of persistent non-vertiginous dizziness, chronic subjective dizziness (CSD) arises unsteadily by psychological and physiological imbalance. The CSD is hypersensitivity reaction due to exposure to complex motions visual stimuli. However, the pathophysiological features and mechanism of the CSD still remains unclearly. The present study was purposed to establish possible endogenous contributors of the CSD using serum samples from patients with the CSD. A total 199 participants were gathered and divided into two groups; healthy (n = 152, male for 61, and female for 91) and CSD (n = 47, male for 5, female for 42), respectively. Oxidative stress parameters such as, hydrogen peroxide and reactive substances were significantly elevated (p < 0.01 or p < 0.001), whereas endogenous antioxidant components including total glutathione contents, and activities of catalase and superoxide dismutase were significantly deteriorated in the CSD group (p < 0.01 or p < 0.001) as comparing to the healthy group, respectively. Serum levels of tumor necrosis factor -α and interferon-γ were significantly increased in the CSD participants (p < 0.001). Additionally, emotional stress related hormones including cortisol, adrenaline, and serotonin were abnormally observed in the serum levels of the CSD group (p < 0.01 or p < 0.001). Our results confirmed that oxidative stress and antioxidants are a critical contributor of pathophysiology of the CSD, and that is first explored to establish features of redox system in the CSD subjects compared to a healthy population
A case of primary psoas abscess presenting as buttock abscess
Buttock abscess is a rare clinical manifestation from unusual extrapelvic extension of psoas abscess. A 48-year-old woman presented with painful swelling of the buttock with a sense of local heat. Magnetic resonance imaging revealed a large subfascial abscess over the glutei muscles and was traced into the intraabdominal cavity over the iliac wing to the psoas muscle. Both the psoas abscess and the buttock abscess were evacuated via separate approaches. Empirical antibiotic therapy was delivered for 3 weeks. After 6 months, no evidence of recurrence was found. Psoas abscess could be included in the differential diagnosis of buttock abscess
Generation of high concentration nanobubbles based on friction tubes
Nanobubble-related technologies have been confirmed to be useful in various
fields such as climate change and the environment as well as water-based
industries such as water purification, crops, horticulture, medical care, bio,
and sterilization. However, a method of mass production in real time enough to
apply nano-bubbles to the industry has not yet been developed. We explored the
mechanism of nano-bubble water generation by friction between water and walls
and developed a tube device applying the shape of the flow path to maximize the
friction in the fluid passing through the flow path. It also describes the case
of real-time and low-power mass production of nanobubbles and its technical
utility. We found that the friction of nanotubes alone can easily and quickly
improve the production of nanobubbles with small particle size in real time; by
increasing the shearing pressure while increasing the effective friction
constant value, the particle size of nanobubbles can be smaller while
increasing the particle concentration.Comment: 24 pages, 24 figures, 6 table
Friction Tubes to Generate Nanobubble Ozone Water with an Increased Half-Life for Virucidal Activity
Nanobubbles and related technologies are expected to be highly utilized in
water resource-based industries such as water purification, crops,
horticulture, medicine, bio, and sterilization. Ozone, a chemical with high
sterilizing power, is known as a natural substance that is reduced to oxygen
and water after reacting with pollutants. Ozone water, which is generated by
dissolving ozone in water, has been used in various industrial sectors such as
medical care, food, and environment. Due to the unstable molecular state of
ozone, however, it is difficult to produce, use, and supply ozone at industrial
sites in a stable manner. This study proposed a method for constructing a
system that can generate high-concentration ozone water in large quantities
using low power in real time and maintaining the concentration of the generated
ozone water over the long term. Friction tubes (called 'nanotube') played a key
role to generate nanobubble ozone water with an increased half-life for virus
killing activity. In addition, the safety of ozone water during its spray into
the air was explained, and virucidal activity test cases for the influenza A
(H1N1/A/PR8) and COVID-19 (SARS-CoV-2) virus using high-concentration ozone
water as well as its technical efficacy were described
Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: a systematic review
Effect of Intraoral Balancing Appliance Therapy on Tic disorder Non-Randomized, Observational Clinical Study
Surgical repair of descending thoracic and thoracoabdominal aortic aneurysm involving the distal arch: Open proximal anastomosis under deep hypothermia versus arch clamping technique
BackgroundSurgical repair of a descending thoracic and thoracoabdominal aortic aneurysm (DTA/TAAA) involving the distal arch is challenging and requires either deep hypothermic circulatory arrest (DHCA) or crossclamping of the distal arch. The aim of this study was to compare these 2 techniques in the treatment of DTA/TAAA involving the distal arch.MethodsFrom 1994 to 2012, 298 patients underwent open repair of DTA/TAAA through a left thoracotomy. One hundred seventy-four patients with distal arch involvement who were suitable for either DHCA (n = 81) or arch clamping (AC; n = 93), were analyzed. In-hospital outcomes were compared using propensity scores and inverse-probability-of-treatment weighting adjustment to reduce treatment selection bias.ResultsEarly mortality was 11.1% in the DHCA group and 8.6% in the AC group (P = .58). Major adverse outcomes included stroke in 16 patients (9.2%), low cardiac output syndrome in 15 (8.6%), paraplegia in 10 (5.7%), and multiorgan failure in 10 (5.7%). After adjustment, patients who underwent DHCA were at similar risk of death (odds ratio [OR], 1.14; P = .80) and permanent neurologic injury (OR, 0.95; P = .92) to those who underwent AC. Although prolonged ventilator support (>24 hours) was more frequent with DHCA than with AC (OR, 2.60; P = .003), DHCA showed a tendency to lower the risk of paraplegia (OR, 0.15; P = .057).ConclusionsCompared with AC, DHCA did not increase postoperative mortality and morbidity, except for prolonged ventilator support. However, DHCA may offer superior spinal cord protection to AC during repair of DTA/TAAA involving the distal arch
Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer
Objective. Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies. We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes. Methods. We retrieved 145 cases of GC who had undergone curative gastrectomy. The expression levels of Cav-1 was evaluated by immunohistochemistry, and its association with clinicopathological parameters and patient survival was analyzed. Results. High expression of Cav-1 protein of the GC in the stomach and metastatic lymph node was 12.4% (18/145) and 16.5% (15/91). In the multivariate analysis, tumoral Cav-1 protein in metastatic lymph node showed prognostic significance for relapse-free survival (RFS, HR, 3.934; 95% CI, 1.882–8.224; P=0.001) and cancer-specific survival outcome (CSS, HR, 2.681; 95% CI, 1.613–8.623; P=0.002). Among the GCs with metastatic lymph node, it remained as a strong indicator of poor prognosis for RFS (HR, 3.136; 95% CI, 1.444–6.810; P=0.004) and CSS (HR, 2.509; 95% CI, 1.078–5.837; P=0.032). Conclusion. High expression of tumoral Cav-1 protein in metastatic lymph node is associated with unfavorable prognosis of curative resected GC, indicating the potential of novel prognostic markers
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