39 research outputs found
Radical scavenging activitybased and AP-1-targeted anti-inflammatory effects of lutein in macrophage-like and skin keratinocytic cells,”
Lutein is a naturally occurring carotenoid with antioxidative, antitumorigenic, antiangiogenic, photoprotective, hepatoprotective, and neuroprotective properties. Although the anti-inflammatory effects of lutein have previously been described, the mechanism of its anti-inflammatory action has not been fully elucidated. Therefore, in the present study, we aimed to investigate the regulatory activity of lutein in the inflammatory responses of skin-derived keratinocytes or macrophages and to elucidate the mechanism of its inhibitory action. Lutein significantly reduced several skin inflammatory responses, including increased expression of interleukin-(IL-) 6 from LPS-treated macrophages, upregulation of cyclooxygenase-(COX-) 2 from interferon-/tumor necrosis-factor-(TNF-) -treated HaCaT cells, and the enhancement of matrix-metallopeptidase-(MMP-) 9 level in UV-irradiated keratinocytes. By evaluating the intracellular signaling pathway and the nuclear transcription factor levels, we determined that lutein inhibited the activation of redox-sensitive AP-1 pathway by suppressing the activation of p38 and c-Jun-N-terminal kinase (JNK). Evaluation of the radical and ROS scavenging activities further revealed that lutein was able to act as a strong anti-oxidant. Taken together, our findings strongly suggest that lutein-mediated AP-1 suppression and anti-inflammatory activity are the result of its strong antioxidative and p38/JNK inhibitory activities. These findings can be applied for the preparation of anti-inflammatory and cosmetic remedies for inflammatory diseases of the skin
Electrochemical and Spectroscopic Analysis of Mg<sup>2+</sup> Intercalation into Thin Film Electrodes of Layered Oxides: V<sub>2</sub>O<sub>5</sub> and MoO<sub>3</sub>
Electrochemical, surface, and structural
studies related to rechargeable
Mg batteries were carried out with monolithic thin-film cathodes comprising
layered V<sub>2</sub>O<sub>5</sub> and MoO<sub>3</sub>. The reversible
intercalation reactions of these electrodes with Mg ion in nonaqueous
Mg salt solutions were explored using a variety of analytical tools.
These included slow-scan rate cyclic voltammetry (SSCV), chrono-potentiometry
(galvanostatic cycling), Raman and photoelectron spectroscopies, high-resolution
microscopy, and XRD. The V<sub>2</sub>O<sub>5</sub> electrodes exhibited
reversible Mg-ion intercalation at capacities around 150–180
mAh g<sup>–1</sup> with 100% efficiency. A capacity of 220
mAh g<sup>–1</sup> at >95% efficiency was obtained with
MoO<sub>3</sub> electrodes. By applying the electrochemical driving
force
sufficiently slowly it was possible to measure the electrodes at equilibrium
conditions and verify by spectroscopy, microscopy, and diffractometry
that these electrodes undergo fully reversible structural changes
upon Mg-ion insertion/deinsertion cycling
High Areal Capacity Hybrid Magnesium–Lithium-Ion Battery with 99.9% Coulombic Efficiency for Large-Scale Energy Storage
Hybrid magnesium–lithium-ion
batteries (MLIBs) featuring dendrite-free deposition of Mg anode and
Li-intercalation cathode are safe alternatives to Li-ion batteries
for large-scale energy storage. Here we report for the first time
the excellent stability of a high areal capacity MLIB cell and dendrite-free
deposition behavior of Mg under high current density (2 mA cm<sup>–2</sup>). The hybrid cell showed no capacity loss for 100
cycles with Coulombic efficiency as high as 99.9%, whereas the control
cell with a Li-metal anode only retained 30% of its original capacity
with Coulombic efficiency well below 90%. The use of TiS<sub>2</sub> as a cathode enabled the highest specific capacity and one of the
best rate performances among reported MLIBs. Postmortem analysis of
the cycled cells revealed dendrite-free Mg deposition on a Mg anode
surface, while mossy Li dendrites were observed covering the Li surface
and penetrated into separators in the Li cell. The energy density
of a MLIB could be further improved by developing electrolytes with
higher salt concentration and wider electrochemical window, leading
to new opportunities for its application in large-scale energy storage
Coating lithium titanate anodes with a mixed ionic-electronic conductor for high-rate lithium-ion batteries
Lithium titanate (Li4Ti5O12; LTO) is a promising anode material for fast (dis)charging Li-ion batteries (LIBs). However, its low Li diffusion coefficient and electronic conductivity limit its applications. Here, we uniformly coat the LTO surface with a 1.6 nm layer of partially lithiated titania (LixTiO2, x approximate to 0.5), which is found to be a mixed ionic-electronic conductor (MIEC), using a simple solid-state method. The MIEC layer simultaneously transfers electrons and Li-ions, facilitating efficient charge transfer to (de)lithiate LTO over the entire particle surface. MIEC-nanocoated LTO exhibits highly improved capacity retention and rate capability than pristine LTO; based on electrochemical simulations, MIEC nanocoating causes performance enhancement by maximum surface-area utilization for charge transfer. Furthermore, electrochemical impedance spectroscopy and density functional theory calculations confirm facile ionic transport and high electronic conductivity of LixTiO2 nano -layer. This general strategy of MIEC nanocoating can boost the electrochemical performances of various insu-lating electrodes, maximizing the materials utilization
Potential-Dependent Passivation of Zinc Metal in a Sulfate-Based Aqueous Electrolyte
Owing to its abundance, high theoretical capacity, and low electrode potential, zinc is one of the most important metallic anodes for primary and secondary batteries such as alkaline and zinc-air batteries. In the operation of zinc-based batteries, passivation of the anode surface plays an essential role because the electrode potential of zinc is slightly below that of the hydrogen evolution reaction. Therefore, it is important to scrutinize the nature of the passivation film to achieve anticorrosion inside batteries. Herein, the potential-dependent formation and removal of the passivation film during the deposition and dissolution of zinc metal in aqueous electrolytes are detected via electrochemical quartz crystal microbalance analysis. Film formation was not noticeable in hydroxide-based electrolytes; however, sulfate-based electrolytes induced potential-dependent formation and removal of the passivation film, enabling a superior coulombic efficiency of 99.37% and significantly reducing the rate of corrosion of the zinc-metal anodes. These observations provide insights into the development of advanced electrolytes for safe and stable energy-storage devices based on zinc-metal anodes.