Computerized Dynamic Posturography: Comparison of Results Obtained from Individuals with Symptomatic Osteoarthritis of the Knee and Controls

Introduction: The purpose of this study was to compare the balance of individuals with knee OA and healthy peers and to determine the effect of knee OA on balance by matching gender, age, mass, height, and BMI. Material and Methods: Thirty-two individuals, sixteen with knee osteoarthritis and sixteen healthy, were evaluated on balance as measured by a NeuroCom EquiTest Sensory Organization Test and Motor Control test protocol. Outcomes included an equilibrium composite score, equilibrium scores on six sensory conditions, and sensory ratios for visual, somatosensory, vestibular systems as well as ability to manage altered proprioceptive inputs. Results: The healthy knee group showed that significantly higher equilibrium scores, higher strategy scores, higher sensory analysis ratios, and faster latency in the analysis of sensory organization test and motor control test. Conclusion: The existence of knee OA affected the effectiveness of the sensory system and the use of this signal in maintaining body balance. Introducción: El propósito de este estudio fue comparar el equilibrio de individuos con osteoartritis (OA) de rodilla y sujetos sanos y determinar el efecto de la OA de rodilla en equilibrio, en función del sexo, la edad, la masa, la altura y el IMC. Material y métodos: Treinta y dos individuos, dieciséis con osteoartritis de rodilla y dieciséis sujetos sanos, se evaluaron en equilibrio según un protocolo de control de motor y prueba sensorial NeuroCom EquiTest. Los resultados incluyeron una puntuación compuesta de equilibrio, puntuaciones de equilibrio en seis condiciones sensoriales y relaciones sensoriales para los sistemas visuales, somatosensoriales y vestibulares, así como la capacidad para gestionar entradas propioceptivas alteradas. Resultados: El grupo de rodilla saludable mostró puntuaciones de equilibrio significativamente más altas, puntuaciones de estrategia más altas, proporciones de análisis sensorial más altas y una latencia más rápida en el análisis de la prueba de organización sensorial y la prueba de control motor. Conclusión: la existencia de OA de rodilla afectó la efectividad del sistema sensorial y el uso de esta señal para mantener el equilibrio corporal

Spoofing Attack Results Determination in Code Domain Using a Spoofing Process Equation

When a user receiver is tracking an authentic signal, a spoofing signal can be transmitted to the user antenna. The question is under what conditions does the tracking point of the receiver move from the authentic signal to the spoofing signal? In this study, we develop a spoofing process equation (SPE) that can be used to calculate the tracking point of the delay lock loop (DLL) at regular chip intervals for the entire spoofing process. The condition for a successful spoofing signal is analyzed using the SPE. To derive the SPE, parameters, such as the signal strength, sweep velocity, loop filter order, and DLL bandwidth are considered. The success or failure of a spoofing attack is determined for a specific spoofing signal using the SPE. In addition, a correlation between each parameter for a successful spoofing attack could be obtained through the SPE. The simulation results show that the SPE performance is largely consistent with that of general DLL methods, even though the computational load of SPE is very low

A Breast Tumor Classification Method based on Ultrasound BI-RADS Data Mining

Abstract-In this paper, to reduce the response time of computer-aided diagnostic (CAD) systems, we proposed a feature selection algorithm that utilizes BI-RADS which is the standard clinical considerations for radiologists to illustrate the visual characteristics of breast tumors. We first apply the association rule mining technique to the medical database annotated with BI-RADS lexicons by doctors, to find out the interesting BI-RADS lexicon values. Then, we select the image processing algorithms which effectively represent the chosen BI-RADS lexicon values. Finally, the features obtained from the selected image processing algorithms are used to build our classifier using Support Vector Machine (SVM) to predict whether each tumor is benign or malignant. Our experimental result shows that our classifier is accurate with fast execution time

Targeting FAK/PYK2 with SJP1602 for Anti-Tumor Activity in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) presents significant challenges due to its aggressive nature and limited treatment options. Focal adhesion kinase (FAK) has emerged as a critical factor promoting tumor growth and metastasis in TNBC. Despite encouraging results from preclinical and early clinical trials with various FAK inhibitors, none have yet achieved clinical success in TNBC treatment. This study investigates the therapeutic potential of a novel dual inhibitor of FAK and PYK2, named SJP1602, for TNBC. In vitro experiments demonstrate that SJP1602 effectively inhibits FAK and PYK2 activities, showing potent effects on both kinases. SJP1602 shows concentration-dependent inhibition of cell growth, migration, invasion, and 3D spheroid formation in TNBC cell lines, surpassing the efficacy of other FAK inhibitors. Pharmacokinetic studies in rats indicate favorable bioavailability and sustained plasma concentrations of SJP1602, supporting its potential as a therapeutic agent. Furthermore, in TNBC xenograft models, SJP1602 exhibits significant dose-dependent inhibition of tumor growth. These promising results emphasize the potential of SJP1602 as a potent dual inhibitor of FAK and PYK2, deserving further investigation in clinical trials for TNBC treatment

The Effect of Adding Biological Factors to the Decision-Making Process for Spinal Metastasis of Non-Small Cell Lung Cancer

Molecular target therapies have markedly improved the survival of non-small cell lung cancer (NSCLC) patients, especially those with epidermal growth factor receptor (EGFR) mutations. A positive EGFR mutation is even more critical when the chronicity of spinal metastasis is considered. However, most prognostic models that estimate the life expectancy of spinal metastasis patients do not include these biological factors. We retrospectively reviewed 85 consecutive NSCLC patients who underwent palliative surgical treatment for spinal metastases to evaluate the following: (1) the prognostic value of positive EGFR mutation and the chronicity of spinal metastasis, and (2) the clinical significance of adding these two factors to an existing prognostic model, namely the New England Spinal Metastasis Score (NESMS). Among 85 patients, 38 (44.7%) were EGFR mutation-positive. Spinal metastasis presented as the initial manifestation of malignancy in 58 (68.2%) patients. The multivariate Cox proportional hazard model showed that the chronicity of spinal metastasis (hazard ratio (HR) = 1.88, p = 0.015) and EGFR mutation positivity (HR = 2.10, p = 0.002) were significantly associated with postoperative survival. The Uno’s C-index and time-dependent AUC 6 months following surgery significantly increased when these factors were added to NESMS (p = 0.004 and p = 0.022, respectively). In conclusion, biological factors provide an additional prognostic value for NSCLC patients with spinal metastasis

Anterior Thigh Pain Following Minimally Invasive Oblique Lateral Interbody Fusion: Multivariate Analysis from a Prospective Case Series

© 2022 by The Korean Orthopaedic Association.Background: Oblique lateral interbody fusion (OLIF) involves the antepsoas approach and psoas major muscle (PMM) retraction to insert the interbody cage orthogonally. Therefore, OLIF is often associated with postoperative anterior thigh pain (ATP) on the approach side. However, there is limited evidence on the nature and risk factors of ATP following OLIF. Methods: Consecutive patients who planned to undergo minimally invasive OLIF and percutaneous pedicle screw instrumentation for lumbar degenerative diseases were prospectively enrolled. The visual analog scale (VAS) for ATP was recorded, and a pain map was drawn daily from the operation day to postoperative day 7 in all patients. We also prospectively collected the preoperative and intraoperative data to identify the risk factors associated with ATP. Radiologically, the total cross-sectional area (CSA), retraction length, and retraction CSA of PMM were measured from the preoperative T2-weighted axial magnetic resonance imaging scans at the L4–5 intervertebral disc level. The patients were stratified into two groups based on the experience of ATP with a VAS score of ≥ 7 at any time point. Additionally, a binary logistic regression analysis was performed to identify the associated factors. Results: The current prospective study included 92 patients (31 men, 61 women) with a mean age of 70.4 years (range, 56–86 years), who underwent OLIF at our institution. The left-side approach was used in 73 patients (79.3%), while 19 (20.7%) underwent a right-side approach. Sixty-five of the total patients (70.6%) experienced approach-side ATP to any extent during postoperative 0–7 days following OLIF. The mean pain VAS (4.4 ± 2.1) and the prevalence (57.6%) were highest at postoperative 2 days. On postoperative day 7, there were 19 patients (20.7%) who complained of residual ATP with a mean VAS of 2.6 ± 1.8. In the multivariate analysis, the PMM retraction length was significantly associated with ATP of VAS ≥ 7 (adjusted odds ratio, 2.316; p = 0.044). Conclusions: In this study, we prospectively collected and analyzed the ATP and associated factors following OLIF and identified the PMM retraction length as a potential independent risk factor for severe ATP in the immediate postoperative period following OLIF.Y

The Effect of Adding Biological Factors to the Decision-Making Process for Spinal Metastasis of Non-Small Cell Lung Cancer

Molecular target therapies have markedly improved the survival of non-small cell lung cancer (NSCLC) patients, especially those with epidermal growth factor receptor (EGFR) mutations. A positive EGFR mutation is even more critical when the chronicity of spinal metastasis is considered. However, most prognostic models that estimate the life expectancy of spinal metastasis patients do not include these biological factors. We retrospectively reviewed 85 consecutive NSCLC patients who underwent palliative surgical treatment for spinal metastases to evaluate the following: (1) the prognostic value of positive EGFR mutation and the chronicity of spinal metastasis, and (2) the clinical significance of adding these two factors to an existing prognostic model, namely the New England Spinal Metastasis Score (NESMS). Among 85 patients, 38 (44.7%) were EGFR mutation-positive. Spinal metastasis presented as the initial manifestation of malignancy in 58 (68.2%) patients. The multivariate Cox proportional hazard model showed that the chronicity of spinal metastasis (hazard ratio (HR) = 1.88, p = 0.015) and EGFR mutation positivity (HR = 2.10, p = 0.002) were significantly associated with postoperative survival. The Uno’s C-index and time-dependent AUC 6 months following surgery significantly increased when these factors were added to NESMS (p = 0.004 and p = 0.022, respectively). In conclusion, biological factors provide an additional prognostic value for NSCLC patients with spinal metastasis

Structural Femoral Shaft Allografts for Anterior Spinal Column Reconstruction in Osteoporotic Spines

This study was to investigate the clinical and radiographical outcomes of anterior spinal column reconstruction using structural femoral shaft allografts in osteoporotic patients. Retrospective analyses of medical records, radiographic parameters, and postoperative complications were performed in twenty-one patients who underwent anterior spinal column reconstruction surgery for osteoporotic vertebral collapse or nonunion. Surgical invasiveness, clinical outcomes, postoperative complications, and radiographic outcomes were evaluated. Ambulatory status and back pain significantly improved. The Cobb’s angle of segmental kyphosis significantly improved immediately after surgery with slight progression at the final follow-up. There were two cases of failed reconstruction with marked progression of kyphosis; both were related to loosening of screws rather than subsidence of the graft. Anterior spinal column reconstruction using femoral shaft allografts improved kyphosis and resulted in minimal subsidence and therefore is recommended as an effective treatment option for dealing with osteoporotic vertebral collapse and kyphotic deformity

NiO as Hole Transporting Layer for Inverted Perovskite Solar Cells: A Study of X‐Ray Photoelectron Spectroscopy

Abstract Hygroscopic and acidic nature of organic hole transport layers (HTLs) insisted to replace it with metal oxide semiconductors due to their favorable charge carrier transport with long chemical stability. Apart from large direct bandgap and high optical transmittance, ionization energy in the range of −5.0 to −5.4 eV leads to use NiO as HTL due to good energetic matching with lead halide perovskites. Analyzing X‐ray photoelectron spectroscopic (XPS) data of NiO, it is speculated that p‐type conductivity is related to the NiOOH or Ni2O3 states in the structure and the electrical conductivity can be modified by altering the concentration of nickel or oxygen vacancies. However, it is difficult to separate the contribution from nonlocal screening, surface effect and the presence of vacancy induced Ni3+ ion due to very strong satellite structure in the Ni 2p XPS spectrum of NiO. Thus, an effective approach to analyze the NiO XPS spectrum is presented and the way to correlate the presence of Ni3+ with the conductivity results which will help to avoid overestimation in finding the oxygen‐rich/deficient conditions in NiO

Surgical Causes of Significant Intraoperative Neuromonitoring Signal Changes in Three-Column Spinal Surgery

Study Design: Retrospective case series. Purpose: To evaluate the risks and causes of neurologic complications in three-column spinal surgery by analyzing intraoperative neurophysiological monitoring (IONM) data. Overview of Literature: Three-column spinal surgery, which may be required to correct complex spinal deformities or resection of spinal tumors, is known to carry a high risk of neurologic complications. However, few studies reported a specific surgical procedure related to a significant IONM signal change during surgery. Methods: Multimodality IONM data, including somatosensory-evoked potentials (SSEP) and motor-evoked potentials (MEP), were reviewed in 64 patients who underwent three-column spinal surgery from 2011 to 2015. Surgical procedures included posterior vertebral column resection, pedicle subtraction osteotomy, total en bloc spondylectomy, piecemeal spondylectomy, and corpectomy with laminectomy (n=27) in three cervical, 34 thoracic, and 31 lumbar procedures. Results: Significant IONM signal changes occurred in 11 of 64 (17.1%) patients. SSEP and MEP were changed in 11 patients. Postoperative neurologic deterioration occurred in 54.5% (6 of 11) of the patients, and two of them were permanent. There was no postoperative neurologic deterioration in patients without significant signal change. Suspected causes of IONM data changes are as follows: adhesion/tethering, translation, contusion, and perfusion. Conclusions: Based on the results of this study, to enhance neurologic safety in three-column spinal surgery, surgeons should pay attention to protect the spinal cord from mechanical insult, especially when the spinal column was totally destabilized during surgery, and not to compromise perfusion to the spinal cord in close cooperation with a neurologist and anesthesiologist.N