Protein profiles with two-dimensional electrophoresis.

<p>(A) Striatal tissue proteins obtained over different pI ranges. (B) Identified protein spots in gels. Differentially-expressed protein spots are circled with green. (C) Cluster matrix analysis. Red corresponds to high expression and green corresponds to low expression.</p

Expression of tyrosine hydroxylase in the nigrostriatal pathway on day 3.

<p>MPTP injection induced dopaminergic neuronal death in the substantia nigra (A) and the striatum (B), but KRG administration suppressed it. Scale bar, 200 μm. Data are presented as the means ± standard deviation. *<i>p</i> < 0.05 and **<i>p</i> < 0.01.</p

Results of the pole test.

<p>MPTP administration induced an increase in the descending time of mice, which was restored by oral administration of Korean Red Ginseng (KRG). Data are presented as the means ± the standard deviation. **<i>p</i> < 0.01. Saline, vehicle injected group; MPTP, MPTP injected group; MPTP+KRG, MPTP injected and KRG administrated group.</p

Protein levels differentially expressed in the striatum.

<p>The levels were illustrated as the relative normalized volumes (RNV) of the proteins. Bars represent the means ± standard deviation (n = 3 at each group). *<i>p</i> < 0.05, ** <i>p</i> < 0.01 and *** <i>p</i> < 0.001. Arrowheads represent protein spots.</p

List of differentially expressed protein spots following MPTP and KRG administration.

<p>List of differentially expressed protein spots following MPTP and KRG administration.</p

KEGG pathway list of 12 proteins which were down-regulated in MPTP versus saline and up-regulated in MPTP+KRG versus MPTP.

<p>KEGG pathway list of 12 proteins which were down-regulated in MPTP versus saline and up-regulated in MPTP+KRG versus MPTP.</p