77 research outputs found
Automated Structure Solution with the PHENIX Suite
Significant time and effort are often required to solve and complete a macromolecular crystal structure. The development of automated computational methods for the analysis, solution and completion of crystallographic structures has the potential to produce minimally biased models in a short time without the need for manual intervention. The PHENIX software suite is a highly automated system for macromolecular structure determination that can rapidly arrive at an initial partial model of a structure without significant human intervention, given moderate resolution and good quality data. This achievement has been made possible by the development of new algorithms for structure determination, maximum-likelihood molecular replacement (PHASER), heavy-atom search (HySS), template and pattern-based automated model-building (RESOLVE, TEXTAL), automated macromolecular refinement (phenix.refine), and iterative model-building, density modification and refinement that can operate at moderate resolution (RESOLVE, AutoBuild). These algorithms are based on a highly integrated and comprehensive set of crystallographic libraries that have been built and made available to the community. The algorithms are tightly linked and made easily accessible to users through the PHENIX Wizards and the PHENIX GUI
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Labour power and labour process : contesting the marginality of the sociology of work
This article opens by suggesting that the decline in the sociology of work in the UK has been overstated; research continues, but in locations such as business schools. The continued vitality of the field corresponds with material changes in an increasingly globalized capitalism, with more workers in the world, higher employment participation rates of women, transnational shifts in manufacturing, global expansion of services and temporal and spatial stretching of work with advanced information communication technologies. The article demonstrates that Labour Process Theory (LPT) has been a crucial resource in the sociology of work, especially in the UK; core propositions of LPT provide it with resources for resilience (to counter claims of rival perspectives) and innovation (to expand the scope and explanatory power of the sociology of work). The article argues that the concept of the labour power has been critical to underpinning the sustained influence of labour process analysis
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Contain calculations of debris conditions adjacent to the BWR Mark I drywell shell during the later phases of a severe accident
Best estimate CONTAIN calculations have recently been performed by the BWR Severe Accident Technology (BWRSAT) Program at Oak Ridge National Laboratory to predict the primary containment response during the later phases of an unmitigated low-pressure Short Term Station Blackout at the Peach Bottom Atomic Power Station. Debris pour conditions leaving the failed reactor vessel are taken from the results of best estimate BWRSAR analyses that are based upon an assumed metallic debris melting temperature of 2750/degree/F (1783 K) and an oxide debris melting temperature of 4350/degree/F (2672 K). Results of the CONTAIN analysis for the case without sprays indicate failure of the drywell seals due to the extremely hot atmospheric conditions extant in the drywell. The maximum calculated temperature of the debris adjacent to the drywell shell is less than the melting temperature of the shell, yet the sustained temperatures may be sufficient to induce primary containment pressure boundary failure by the mechanism of creep-rupture. It is also predicted that a significant portion of the reactor pedestal wall is ablated during the period of the calculation. Nevertheless, the calculated results are recognized to be influenced by large modeling uncertainties. Several deficiencies in the application of the CORCON module within the CONTAIN code to BWR severe accident sequences are identified and discussed. 5 refs., 9 figs., 4 tabs.
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Effects of improved modeling on best estimate BWR severe accident analysis
Since 1981, ORNL has completed best estimate studies analyzing several dominant BWR accident scenarios. These scenarios were identified by early Probabilistic Risk Assessment (PRA) studies and detailed ORNL analysis complements such studies. In performing these studies, ORNL has used the MARCH code extensively. ORNL investigators have identified several deficiencies in early versions of MARCH with regard to BWR modeling. Some of these deficiencies appear to have been remedied by the most recent release of the code. It is the purpose of this paper to identify several of these deficiencies. All the information presented concerns the degraded core thermal/hydraulic analysis associated with each of the ORNL studies. This includes calculations of the containment response. The period of interest is from the time of permanent core uncovery to the end of the transient. Specific objectives include the determination of the extent of core damage and timing of major events (i.e., onset of Zr/H/sub 2/O reaction, initial clad/fuel melting, loss of control blade structure, etc.). As mentioned previously the major analysis tool used thus far was derived from an early version of MARCH. BWRs have unique features which must be modeled for best estimate severe accident analysis. ORNL has developed and incorporated into its version of MARCH several improved models. These include (1) channel boxes and control blades, (2) SRV actuations, (3) vessel water level, (4) multi-node analysis of in-vessel water inventory, (5) comprehensive hydrogen and water properties package, (6) first order correction to the ideal gas law, and (7) separation of fuel and cladding. Ongoing and future modeling efforts are required. These include (1) detailed modeling for the pressure suppression pool, (2) incorporation of B/sub 4/C/steam reaction models, (3) phenomenological model of corium mass transport, and (4) advanced corium/concrete interaction modeling. 10 references, 17 figures, 1 table
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Station blackout calculations for Browns Ferry
This paper presents the results of calculations performed with the ORNL SASA code suite for the Station Blackout Severe Accident Sequence at Browns Ferry. The accident is initiated by a loss of offsite power combined with failure of all onsite emergency diesel generators to start and load. The Station Blackout is assumed to persist beyond the point of battery exhaustion (at six hours) and without DC power, cooling water could no longer be injected into the reactor vessel. Calculations are continued through the period of core degradation and melting, reactor vessel failure, and the subsequent containment failure. An estimate of the magnitude and timing of the concomitant fission product releases is also provided
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Effects of lateral separation of oxidic and metallic core debris on the BWR MK I containment drywell floor
In evaluating core debris/concrete interactions for a BWR MK I containment design, it is common practice to assume that at reactor vessel breach, the core debris is homogeneous and of low viscosity, so that it flows through the pedestal doorway and spreads in a radially uniform fashion throughout the drywell floor. In a recent study performed by the NRC-sponsored Severe Accident Sequence Analysis (SASA) program at Oak Ridge National Laboratory, calculations indicate that at reactor vessel bottom head failure, the debris temperature is such that the debris metals (Zr, Fe, Ni, Cr) are completely molten while the oxides (UO/sub 2/ ZrO/sub 2/, FeO) are completely frozen. Thus, the frozen oxides are expected to remain within the reactor pedestal while the molten metals radially separate from the frozen oxides, flow through the reactor pedestal doorway, and spread over the annular region of the drywell floor between the pedestal and the containment shell. This paper assesses the impact on calculated containment response and the production and release of fission product-laden aerosols for two different cases of debris distribution: uniform distribution and the laterally separated case of 95% oxides-5% metals inside the pedestal and 5% oxides-95% metals outside the pedestal. The computer codes used are CORCON-MOD2, MARCON 2.1B and VANESA
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Characterization of debris/concrete interactions for advanced research reactor and commercial BWR severe accidents
The core concrete interaction (CCI) is an important phase of any severe accident where the reactor vessel has failed and core debris is relocated onto the containment basemat. In recent calculations performed at the Oak Ridge National Laboratory (ORNL), CCI has been studied for severe accidents occurring in a commercial Boiling Water Reactor (BWR) and in a high-power density Department of Energy (DOE) research reactor that is currently in the conceptual design stage. Because of differences in the debris decay heating level, core debris composition and inventory, and containment design, the characteristics of the resulting CCI and containment response are different for the two reactor types. Furthermore, proper selection of the basemat concrete type and the provision of an overlying water pool are found to be significant CCI mitigating factors for the research reactor and thus constitute important design considerations for any future reactor type. 10 refs., 4 figs., 1 tab
PWR blowdown heat transfer separate-effects program data evaluation report: system response for thermal-hydraulic test facility test series 100
Selected reduced instrument responses and analyses of the indicated phenomena are presented for Thermal-Hydraulic Test Facility (THTF) test series 100, which is part of the PWR Blowdown Heat Transfer Separate-Effects Program. The objective of the program is to investigate the thermal-hydraulic phenomena that govern the energy transfer and transport processes occurring during a postulated loss-of-coolant accident in a pressurized-water reactor system. Comparisons are made between the trends indicated by the reduced instrument responses and the thermal-hydraulic transient simulator RELAP4/MOD5 (update 2) to aid in understanding the phenomenological sequences. The results of verification studies of RELAP's performance in prediction of the THTF data are presented
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