細菌およびヒト培養細胞に対するデヒドロ酢酸ナトリウムの影響(B. 生活科学)

食品添加物DHA-Sの, E. coliおよびS. aureusに対する静菌的効果について検討した。また培養ヒトFL-細胞の増殖に及ぼす影響を検討した。DHA-Sの作用濃度として, 0.05%および1%を設定した。1.細菌に対する静菌効果は, 1%においては完全に増殖を抑制したが, 0.05%においては極く僅かにその増殖を抑制した。但し, S. aureusに対しては, 24hrを経過した時点では静菌的効果は認められなかった。2. FL-細胞に対しては, 1%濃度においては作用後5日目において著しく増殖を阻害した。0.05%濃度においては, 増殖抑制効果は認められなかった。3.電子顕微鏡によってDHA-SのFL-細胞に対する形態学的影響を観察したが, 1%濃度においては, 退化的な細胞変性を来たし, 遂には細胞は破壊された。The toxic effects on bacteria (E. coli and S. aureus) and cultured human FL-cells of sodium dehydroacetate (DHA-S), a food preservative used in Japan for cheese, butter, and margarine, were studied. 1. DHA-S in a concentration of 1% markedly inhibited the growth of both bacterial strains after 24hr in culture. In a concentration of 0.05%, the slightly depressed growth of both strains was observed after 6hr in culture, but no significant effect on S. aureus was observed after 24hr. 2. The growth of cultured FL-cells treated with 1% DHA-S for 5min was depressed to about 5% of control at 5days after treatment. Treatment with 0.05% DHA-S had no detectable effect on the growth of FL-cells. 3. The morphologic effects of 1% DHA-S on Fl-cells were degenerative changes such as swelling of mitochondrion and fragmentations of nuclear envelope and plasma membrane

Community-associated Methicillin-resistant Staphylococcus aureus Bacteremia and Endocarditis among HIV Patients: A cohort study

<p>Abstract</p> <p>Background</p> <p>HIV patients are at increased risk of development of infections and infection-associated poor health outcomes. We aimed to 1) assess the prevalence of USA300 community-associated methicillin-resistant <it>Staphylococcus aureus </it>(CA-MRSA) among HIV-infected patients with <it>S. aureus </it>bloodstream infections and. 2) determine risk factors for infective endocarditis and in-hospital mortality among patients in this population.</p> <p>Methods</p> <p>All adult HIV-infected patients with documented <it>S. aureus </it>bacteremia admitted to the University of Maryland Medical Center between January 1, 2003 and December 31, 2005 were included. CA-MRSA was defined as a USA300 MRSA isolate with the MBQBLO spa-type motif and positive for both the arginine catabolic mobile element and Panton-Valentin Leukocidin. Risk factors for <it>S. aureus</it>-associated infective endocarditis and mortality were determined using logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI). Potential risk factors included demographic variables, comorbid illnesses, and intravenous drug use.</p> <p>Results</p> <p>Among 131 episodes of <it>S. aureus </it>bacteremia, 85 (66%) were MRSA of which 47 (54%) were CA-MRSA. Sixty-three patients (48%) developed endocarditis and 10 patients (8%) died in the hospital on the index admission Patients with CA-MRSA were significantly more likely to develop endocarditis (OR = 2.73, 95% CI = 1.30, 5.71). No other variables including comorbid conditions, current receipt of antiretroviral therapy, pre-culture severity of illness, or CD4 count were significantly associated with endocarditis and none were associated with in-hospital mortality.</p> <p>Conclusions</p> <p>CA-MRSA was significantly associated with an increased incidence of endocarditis in this cohort of HIV patients with MRSA bacteremia. In populations such as these, in which the prevalence of intravenous drug use and probability of endocarditis are both high, efforts must be made for early detection, which may improve treatment outcomes.</p

Environmental radioactivity at Argonne National Laboratory : report for the year 1958 /

"August 1959"Operated by the University of Chicago underMode of access: Internet

A review of the Argonne National Laboratory radiation exposure experience for the years 1959-1961 /

"February 1963"Operated by the University of Chicago underMode of access: Internet

Environmental radioactivity at Argonne National Laboratory : report for the year 1957 /

"October, 1958""Industrial Hygiene and Safety Division""AEC Research and Development Report""TID-4500 (14th Ed.)""Health and Safety"Includes bibliographic references.Operated by The University of ChicagoMode of access: Internet

Environmental radioactivity at Argonne National Laboratory : Report for the Year 1964 /

This report presents the results of the environmental monitoring program at Argonne National Laboratory during 1964. The purposes of the program are to measure the natural radioactive content of the ANL site and its surroundings, and to determine the origin, identity, and magnitude of any radioactivity not naturally present. Of primary interest is the detection of radioactive materials release to the environment as a result of Argonne operations.Experimental work done by: C. D. Eldred, N. W. Golchert, C. M. Greene, Jr., F. S. Iwami, K. K. Kamalick, D. G. Kaplan, J. Sedlet.Industrial Hygiene and Safety Division, ANL."October 1965."This report presents the results of the environmental monitoring program at Argonne National Laboratory during 1964. The purposes of the program are to measure the natural radioactive content of the ANL site and its surroundings, and to determine the origin, identity, and magnitude of any radioactivity not naturally present. Of primary interest is the detection of radioactive materials release to the environment as a result of Argonne operations.Operated by the University of ChicagoMode of access: Internet

Proceedings of the seventh annual Meeting on Bio-Assay and Analytical Chemistry : held October 12 and 13, 1961 at Argonne National Laboratory /

AEC research and development report."Chemistry (TID-4500, 18th ed.)."Bibliographical references included.Operated by the University of Chicago underMode of access: Internet

Environmental radioactivity at Argonne National Laboratory : report for the year 1960 and 1961 /

Mode of access: Internet