3 research outputs found
A Reaction-Based Sensing Scheme for Gold Species: Introduction of a (2-Ethynyl)benzoate Reactive Moiety
To alleviate side reactions identified in an <i>N</i>-propargyl-rhodamine lactam sensing system, we devised the novel reaction-based sensing scheme for gold species based on the alkynophilicity. A fluorescein (2-ethynyl)benzoate underwent Au(III)-promoted ester hydrolysis selectively over other metal ions with high sensitivity, which accompanies a turn-on fluorescence change in pH 7.4 HEPES buffer. The work offers a versatile reactive moiety for the development of gold probes with improved sensing properties
Ground-State Elevation Approach To Suppress Side Reactions in Gold-Sensing Systems Based on Alkyne Activation
A novel approach to suppress the
side reactions observed in the
reaction-based gold-sensing systems based on the alkyne activation
is disclosed. By elevating steric strain around the reaction site,
the gold ion promoted ring-opening process in rhodamine-lactam probes
is significantly accelerated, which also leads to suppression of those
possible side reactions. As a result, the probes show very high sensitivity
in addition to excellent selectivity toward gold species. Furthermore,
bioimaging of gold species in live cells was demonstrated with a FRET
version
Groebke–Blackburn–Bienaymé Reaction for DNA-Encoded Library Technology
This study presents a DNA-compatible synthesis of diverse
5-arylimidazo[1,2-a]pyridin-3-amine derivatives using
the Suzuki–Miyaura
reaction, followed by a Groebke–Blackburn–Bienaymé
(GBB) reaction. The GBB reaction demonstrates a wide substrate scope,
mild one-pot reaction conditions, and compatibility with subsequent
enzymatic ligation, highlighting its potential in DNA-encoded library
technology