Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia

IntroductionDespite of massive endeavors to characterize inflammation in COVID-19 patients, the core network of inflammatory mediators responsible for severe pneumonia stillremain remains elusive. MethodsHere, we performed quantitative and kinetic analysis of 191 inflammatory factors in 955 plasma samples from 80 normal controls (sample n = 80) and 347 confirmed COVID-19 pneumonia patients (sample n = 875), including 8 deceased patients. ResultsDifferential expression analysis showed that 76% of plasmaproteins (145 factors) were upregulated in severe COVID-19 patients comparedwith moderate patients, confirming overt inflammatory responses in severe COVID-19 pneumonia patients. Global correlation analysis of the plasma factorsrevealed two core inflammatory modules, core I and II, comprising mainly myeloid cell and lymphoid cell compartments, respectively, with enhanced impact in a severity-dependent manner. We observed elevated IFNA1 and suppressed IL12p40, presenting a robust inverse correlation in severe patients, which was strongly associated with persistent hyperinflammation in 8.3% of moderate pneumonia patients and 59.4% of severe patients. DiscussionAberrant persistence of pulmonary and systemic inflammation might be associated with long COVID-19 sequelae. Our comprehensive analysis of inflammatory mediators in plasmarevealed the complexity of pneumonic inflammation in COVID-19 patients anddefined critical modules responsible for severe pneumonic progression

Electronic Skin with Localized Piezoresistive Material for Omni-Directional Pressure Profiling

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Independently Responsive Stretchable Electroluminescent Platform for Electronic Skin under Multi-Stimulation

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Electro-Photoluminescence Color Changing System for Interactive Display and Deformable Visual Encryption

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Accuracy, Robustness, and Efficiency of the Linear Boundary Condition for the Black-Scholes Equations

We briefly review and investigate the performance of various boundary conditions such as Dirichlet, Neumann, linear, and partial differential equation boundary conditions for the numerical solutions of the Black-Scholes partial differential equation. We use a finite difference method to numerically solve the equation. To show the efficiency of the given boundary condition, several numerical examples are presented. In numerical test, we investigate the effect of the domain sizes and compare the effect of various boundary conditions with pointwise error and root mean square error. Numerical results show that linear boundary condition is accurate and efficient among the other boundary conditions

Skin-inspired electrochemical tactility and luminescence

© 2022Animal skin is deformable, yet capable of consistently sensing external stimuli (mechanical, thermal, chemical) without morphological and functional deterioration. This high deformability and signal stability are ensured because the receptors and the signal transmission systems are based on the electrochemical change in the embedded cells. Further, in the skin of various nocturnal animals and deep-sea creatures, electrochemical changes triggered by mechanical stimuli lead to bioluminescence, which can be effective or direct visual feedback that responses to environmental stress in the biological system. In this regard, recently, researches to artificially imitate electrochemical mechanisms of tactile sensation and luminescence in the skin have made remarkable advances in the field of electronic skin (e-skin). This perspective article introduces recent pivot advances in the ion-based tactile sensors and electrochemiluminescent skins, and suggests the technological challenges, then the article ends with perspectives to the skin-inspired ionic artificial devices.11Nsciescopu

Differential Association of Viral Dynamics With Disease Severity Depending on Patients' Age Group in COVID-19

Despite a clear association of patient's age with COVID-19 severity, there has been conflicting data on the association of viral load with disease severity. Here, we investigated the association of viral load dynamics with patient's age and severity of COVID-19 using a set of respiratory specimens longitudinally collected (mean: 4.8 times/patient) from 64 patients with broad distribution of clinical severity and age during acute phase. Higher viral burden was positively associated with inflammatory responses, as assessed by IL-6, C-reactive protein, and lactate dehydrogenase levels in patients' plasma collected on the same day, primarily in the younger cohort (<= 59 years old) and in mild cases of all ages, whereas these were barely detectable in elderly patients (>= 60 years old) with critical disease. In addition, viral load dynamics in elderly patients were not significantly different between mild and critical cases, even though more enhanced inflammation was consistently observed in the elderly group when compared to the younger group during the acute phase of infection. The positive correlation of viral load with disease severity in younger patients may explain the increased therapeutic responsiveness to current antiviral drugs and neutralizing antibody therapies in younger patients compared to elderly patients. More careful intervention against aging-associated inflammation might be required to mitigate severe disease progression and reduce fatality in COVID-19 patients more than 60 years old.Y

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. In β-cell-specific Tph1 knockout (Tph1 βKO) mice, perinatal β-cell proliferation was reduced along with the loss of serotonin production in β-cells. Adult Tph1 βKO mice exhibited glucose intolerance with decreased β-cell mass. Disruption of Htr2b in β-cells also resulted in decreased perinatal β-cell proliferation and glucose intolerance in adulthood. Growth hormone (GH) was found to induce serotonin production in β-cells through activation of STAT5 during the perinatal period. Thus, our results indicate that GH-GH receptor-STAT5-serotonin-HTR2B signaling plays a critical role in determining the β-cell mass by regulating perinatal β-cell proliferation, and defects in this pathway affect metabolic phenotypes in adults