Comparative insight of pesticide transformations between river and wetland systems

The widespread use of pesticides threatens the environment and ecosystems. Despite the positive effects of plant protection products, pesticides also have unexpected negative effects on nontarget organisms. The microbial biodegradation of pesticides is one of the major pathways for reducing their risks at aquatic ecosystems. The objective of this study was to compare the biodegradability of pesticides in simulated wetland and river systems. Parallel experiments were conducted with 17 pesticides based on the OECD 309 guidelines. A comprehensive analytical method, such as target screening combined with suspect and non-target screening, was performed to evaluate the biodegradation via identification of transformation products (TPs) using LC-HRMS. As evidence of biodegradation, we identified 97 TPs for 15 pesticides. Metolachlor and dimethenamid had 23 and 16 TPs, respectively, including Phase II glutathione conjugates. The analysis of 16S rRNA sequences for microbials characterized operational taxonomic units. Rheinheimera and Flavobacterium, which have the potential for glutathione S-transferase, were dominant in wetland systems. Estimation of toxicity, biodegradability, and hydrophobicity using QSAR prediction indicated lower environmental risks of detected TPs. We conclude that the wetland system is more favorable for pesticide degradation and risk mitigation mainly attributed to the abundance and variety of the microbial communities

Effect of Activating a Nickel–Molybdenum Catalyst in an Anion Exchange Membrane Water Electrolyzer

Water electrolysis using anion exchange membranes is promising for hydrogen production, and Ni–Mo catalysts have shown high activity for alkaline hydrogen evolution reaction (HER). However, their performance has been mostly tested in a half-cell setup and rarely studied in a single-cell setup with a membrane electrode assembly (MEA) structure, which is used for practical applications. With Ni3Mo as the cathode, a single cell was fabricated using non-noble metal catalysts exclusively. Interestingly, the activation procedure significantly affected the cell performance. The single cell performed better than that with the Pt/C catalyst when the Ni3Mo catalyst was mildly activated. The distribution of Mo in electrodes, membrane, and electrolytes was estimated, confirming Mo dissolution from the cathode. Once the cell was activated, the cell performance was stable without degradation in long-term chronopotentiometry operation, but the performance was degraded by sudden voltage change such as imposing open circuit voltage (OCV). The surface structure and reaction mechanism were studied with density functional theory: the Mo-dissolved Ni3Mo(101) surface could promote H2O dissociation, while MoO3 stably adsorbed on the surface weakened H* adsorption, promoting HER. This study provides important insights into the development of efficient catalysts for large-scale hydrogen production

Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer

Abstract Background Colon cancer ranks as the second most lethal form of cancer globally. In recent years, there has been active investigation into using the methylation profile of circulating tumor DNA (ctDNA), derived from blood, as a promising indicator for diagnosing and monitoring colon cancer. Results We propose a liquid biopsy-based epigenetic method developed by utilizing 49 patients and 260 healthy controls methylation profile data to screen and monitor colon cancer. Our method initially identified 901 colon cancer-specific hypermethylated (CaSH) regions in the tissues of the 49 cancer patients. We then used these CaSH regions to accurately quantify the amount of circulating tumor DNA (ctDNA) in the blood samples of these same patients, utilizing cell-free DNA methylation profiles. Notably, the methylation profiles of ctDNA in the blood exhibited high sensitivity (82%) and specificity (93%) in distinguishing patients with colon cancer from the control group, with an area under the curve of 0.903. Furthermore, we confirm that our method for ctDNA quantification is effective for monitoring cancer patients and can serve as a valuable tool for postoperative prognosis. Conclusions This study demonstrated a successful application of the quantification of ctDNA among cfDNA using the original cancer tissue-derived CaSH region for screening and monitoring colon cancer

Performance of the Belle II Silicon Vertex Detector

The Belle II experiment at the SuperKEKB collider of KEK (Japan) will accumulate 50 ab−1 of e+e− collision data at an unprecedented instantaneous luminosity of 8 ×1035 cm−2s−1, about 40 times larger than its predecessor. The Belle II vertex detector plays a crucial role in the rich Belle II physics program, especially for time-dependent measurements. It consists of two layers of DEPFET-based pixels and four layers of double sided silicon strips detectors(SVD). The vertex detector has been recently completed and installed in Belle II for the physics run started in spring 2019. We report here results on the commissioning of the SVD and its performance measured with the first collision data set

Data quality monitors of vertex detectors at the start of the Belle II experiment

The Belle II experiment features a substantial upgrade of the Belle detector and will operate at the SuperKEKB energy-asymmetric e+e− collider at KEK in Tsukuba, Japan. The accelerator completed its first phase of commissioning in 2016, and the Belle II detector saw its first electron-positron collisions in April 2018. Belle II features a newly designed silicon vertex detector based on double-sided strip layers and DEPFET pixel layers. A subset of the vertex detector was operated in 2018 to determine background conditions (Phase 2 operation). The collaboration completed full detector installation in January 2019, and the experiment started full data taking. This paper will report on the final arrangement of the silicon vertex detector part of Belle II with a focus on online monitoring of detector conditions and data quality, on the design and use of diagnostic and reference plots, and on integration with the software framework of Belle II. Data quality monitoring plots will be discussed with a focus on simulation and acquired cosmic and collision data

Alignment for the first precision measurements at Belle II

International audienceOn March 25th 2019, the Belle II detector recorded the first collisions delivered by the SuperKEKB accelerator. This marked the beginning of the physics run with vertex detector.The vertex detector was aligned initially with cosmic ray tracks without magnetic field simultaneously with the drift chamber. The alignment method is based on Millepede II and the General Broken Lines track model and includes also the muon system or primary vertex position alignment. To control weak modes, we employ sensitive validation tools and various track samples can be used as alignment input, from straight cosmic tracks to mass-constrained decays.With increasing luminosity and experience, the alignment is approaching the target performance, crucial for the first physics analyses in the era of Super-BFactories. We will present the software framework for the detector calibration and alignment, the results from the first physics run and the prospects in view of the experience with the first data

Alignment for the first precision measurements at Belle II

On March 25th 2019, the Belle II detector recorded the first collisions delivered by the SuperKEKB accelerator. This marked the beginning of the physics run with vertex detector. The vertex detector was aligned initially with cosmic ray tracks without magnetic field simultaneously with the drift chamber. The alignment method is based on Millepede II and the General Broken Lines track model and includes also the muon system or primary vertex position alignment. To control weak modes, we employ sensitive validation tools and various track samples can be used as alignment input, from straight cosmic tracks to mass-constrained decays. With increasing luminosity and experience, the alignment is approaching the target performance, crucial for the first physics analyses in the era of Super-BFactories. We will present the software framework for the detector calibration and alignment, the results from the first physics run and the prospects in view of the experience with the first data

Data quality monitors of vertex detectors at the start of the Belle II experiment

The Belle II experiment features a substantial upgrade of the Belle detector and will operate at the SuperKEKB energy-asymmetric e+e− collider at KEK in Tsukuba, Japan. The accelerator completed its first phase of commissioning in 2016, and the Belle II detector saw its first electron-positron collisions in April 2018. Belle II features a newly designed silicon vertex detector based on double-sided strip layers and DEPFET pixel layers. A subset of the vertex detector was operated in 2018 to determine background conditions (Phase 2 operation). The collaboration completed full detector installation in January 2019, and the experiment started full data taking. This paper will report on the final arrangement of the silicon vertex detector part of Belle II with a focus on online monitoring of detector conditions and data quality, on the design and use of diagnostic and reference plots, and on integration with the software framework of Belle II. Data quality monitoring plots will be discussed with a focus on simulation and acquired cosmic and collision data