Association of <i>PLA2G7</i> V279F genotypes with clinical and biochemical characteristics at baseline and at the end of the three-year follow-up according to BMI.

<p>Association of <i>PLA2G7</i> V279F genotypes with clinical and biochemical characteristics at baseline and at the end of the three-year follow-up according to BMI.</p

Correlation between changes (∆) in Lp-PLA₂ and systolic BP and between changes in oxidized LDL and systolic BP in normal-weight (○) and overweight (*) groups according to the <i>PLA2G7</i> V279F genotype.

<p>(a) Correlation between changes in Lp-PLA₂ and systolic BP in individuals with the VV genotype. (b) Correlation between changes in oxidized LDL and systolic BP in individuals with the VV genotype. (c) Correlation between changes in Lp-PLA₂ and systolic BP in individuals with the VF+FF genotype. (d) Correlation between changes in oxidized LDL and systolic BP in individuals with the VF+FF genotype.</p

Genotype effect of <i>PLA2G7</i> V279F on changes in Lp-PLA₂ activity, systolic BP, and oxidized LDL in the normal-weight and overweight groups at the end of the three-year follow-up compared with the baseline.

<p>Mean ± SE. ^<i>∮</i>tested by logarithmic transformation. ^<i>a</i><i>P</i><0.05, comparison between the VV genotype and F allele in the normal-weight group at baseline. ^<i>b</i><i>P</i><0.05, comparison between the VV genotype and F alleles in the normal-weight group at the end of the three-year follow-up. ^<i>c</i><i>P</i><0.05, comparison between the VV genotype and F allele in the overweight group at baseline. ^<i>d</i><i>P</i><0.05, comparison between the VV genotype and F allele in the overweight group at the end of the three-year follow-up. ^<i>e</i><i>P</i><0.05, comparison of the VV genotype between the normal-weight and overweight groups at baseline. ^<i>f</i><i>P</i><0.05, comparison of the VV allele between the normal-weight and overweight groups at the end of the three-year follow-up. ^<i>g</i><i>P</i><0.05, comparison of the F allele between the normal-weight and overweight groups at baseline. ^<i>h</i><i>P</i><0.05, comparison of the F allele between the normal-weight and overweight groups at the end of the three-year follow-up. ^<i>i</i><i>P</i><0.05, comparison between the VV genotype and F allele in the normal-weight group at change values. ^<i>j</i><i>P</i><0.05, comparison between the VV genotype and F allele in the overweight group at change values. ^<i>k</i><i>P</i><0.05, comparison in the VV genotype between the normal-weight and overweight groups at change values. ^<i>l</i><i>P</i><0.05, comparison of the F allele between the normal-weight and overweight groups at change values. ^<i>*</i><i>P</i><0.05, ^<i>**</i><i>P</i><0.01, and ^<i>***</i><i>P</i><0.001 compared with the levels at baseline in each group, as determined through a paired t-test.</p

Effects of overweight and the <i>PLA2G7</i> V279F polymorphism on the association of age with systolic blood pressure

<div><p>This prospective study aimed to determine the effects of the persistence of overweight for three years and the <i>PLA2G7</i> V279F polymorphism, as well as the interaction between these factors, on the association of age with blood pressure (BP). Healthy middle-aged subjects with normotensive BP were divided into the normal-weight and overweight groups. The <i>PLA2G7</i> V279F genotype, BP, lipoprotein-associated phospholipase A₂ (Lp-PLA₂) activity, and oxidized low-density lipoprotein (ox-LDL) were determined. Lp-PLA₂ activity was lower in the F allele subjects (<i>n</i> = 111) than in those with the VV genotype (<i>n</i> = 389). The overweight individuals with the F allele had lower Lp-PLA₂ activity and ox-LDL at both baseline and after three years and lower systolic and diastolic BP and LDL cholesterol after three years compared with those with the VV phenotype. After three years, the overweight subjects with the VV phenotype exhibited greater increases in Lp-PLA₂ activity, systolic BP, and ox-LDL than those with the F allele and normal-weight subjects with the VV phenotype. A multivariate analysis revealed that the <i>PLA2G7</i> V279F genotype, baseline BMI, changes in Lp-PLA₂ activity and ox-LDL remained independently and positively associated with changes in systolic BP. The simultaneous presence of the <i>PLA2G7</i> 279VV genotype and persistence of overweight synergistically increases the risk for hypertension, whereas lower Lp-PLA₂ activity in <i>PLA2G7</i> 279F allele carriers might offer certain protection against hypertension, even in individuals who have been overweight for over three years.</p></div

Correlations of the changes (∆) in systolic blood pressure.

<p>Correlations of the changes (∆) in systolic blood pressure.</p