4 research outputs found

    Mielopatia associada ao HTLV-I / paraparesia espĂĄstica tropical: relato dos primeiros casos em Sergipe HTLV-I associated myelopathy, tropical spastic paraparesis: report of the first cases in Sergipe-Brazil

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    Mielopatia associada ao HTLV-I / paraparesia espĂĄstica tropical (MAH/PET), tem sido descrita em quase todas as regiĂ”es do Brasil.Os autores apresentam oito casos clinicamente definidos como MAH/PET, os primeiros relatados no Estado de Sergipe .Todos foram positivos para HTLV-I, atravĂ©s do mĂ©todo ELISA, realizado duas vezes; em apenas dois casos foi possĂ­vel a confirmação por Western Blot. De acordo com protocolo de investigação clĂ­nico-laboratorial, todos os pacientes apresentaram acometimento do tracto piramidal, com mĂ­nimo comprometimeto da sensibilidade e alteraçÔes esfincterianas. Os autores chamam a atenção para a endemicidade do HTLV-I no Estado, cuja prevalĂȘncia entre doadores de sangue Ă© significativa (0,43%).HTLV-I associated myelopathy/ tropical spastic paraparesis (HAM/TSP) has been decribed in practically all regions of Brazil. The authors present eight clinically defined cases of HAM/TSP, as being the first reported in Sergipe (Northeastern Brazil). All of them were confirmed through ELISA in two examinations, although only two were confirmed by Western Blot. According to clinical/laboratorial investigation protocol, all patients presented involvement of the pyramidal tract with minimal sensory loss and sphincter alteration. The authors call the attention for the endemicity of HTLV-I in the region, whose prevalence amongst blood donors is significant (0.43%)

    Transcranial doppler in sickle cell anaemia: evaluation of brain blood flow parameters in children of Aracaju, Northeast - Brazil Doppler transcraniano em portadores de anemia falciforme: estudo dos parĂąmetros de fluxo sangĂŒĂ­neo cerebral em crianças de Aracaju, Sergipe

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    BACKGROUND: Environmental factors interfere on sickle cell anaemia (SCA). Transcanial Doppler (TCD) is important to evaluate cerebrovascular disease. OBJECTIVE: To evaluate brain haemodynamic profile of children with SCA in Sergipe. METHODS: Cross sectional study (group1: SCA patients aged 3-18; group2: age and sex matched healthy individuals). Baseline brain flow was evaluated. RESULTS: Group1=34 patients; group 2=81 controls. SCA patients had mean velocity (MV)=125.69 cm/s±23.40; pulsatility index (PI)=0.66±0.10; middle cerebral artery ratio (MCAr)=14.53±15.23; right anterior cerebral artery/right middle cerebral artery=0.77±0.20; left anterior cerebral artery/left middle cerebral artery=0.78±0.20. Controls had MV=79.44±15.54; PI=0.82±0.11; MCAr=13.19±13.77; right anterior cerebral artery/right middle cerebral artery=0.80±0.16; left anterior cerebral artery/left middle cerebral artery=0.84±0.18. MV and PI differences were statistically significant between groups. MV was related to age but not to gender. CONCLUSION: MV evaluation using TCD was similar to international standards and possible to be used in our setting.<br>INTRODUÇÃO: Aspectos ambientais interferem na apresentação da anemia falciforme (AF). Doppler transcraniano (DTC) Ă© Ăștil na avaliação do risco para doença cerebrovascular em pacientes com AF. OBJETIVO: Avaliar o perfil hemodinĂąmico cerebral de crianças com AF em Sergipe. MÉTODO: Estudo transversal (grupo1: portadores de AF 3-18 anos; grupo2: indivĂ­duos saudĂĄveis, pareados por idade e gĂȘnero). Foram avaliadas medidas de fluxo sangĂŒĂ­neo cerebral basal. RESULTADOS: Grupo1 (n=34): velocidade mĂ©dia (Vm)=125,69 cm/s ±23,40; Ă­ndice de pulsatilidade (Ip)=0,66±0,10; relação entre artĂ©ria cerebral mĂ©dia (ACMs)=14,53±15,23; artĂ©ria cerebral anterior (ACA)/ACM direita=0,77±0,20; ACA/ACM esquerda=0,78±0,20. Grupo 2 (n=81): Vm=79,44 cm/s ±15,54; Ip=0,82±0,11, relação entre ACMs=13,19±13,77, ACA/ACM direita=0,80±0,16; ACA/ACM esquerda=0,84± 0,18. Vm foi maior e Ip menor no grupo1. Vm se correlacionou com idade mas nĂŁo com gĂȘnero. CONCLUSÃO: O perfil hemodinĂąmico cerebral de crianças com AF em Sergipe assemelha-se Ă s referĂȘncias internacionais. NĂŁo se observou interferĂȘncia de fatores ambientais sobre os resultados

    Restless legs syndrome in Parkinson's disease: clinical characteristics and biochemical correlations

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    Restless legs syndrome (RLS) is a neurological disorder that responds to dopaminergic drugs, indicating a common pathophysiology with Parkinson's disease (PD). The prevalence of RLS was estimated in a group of PD patients and its clinical and biochemical characteristics were analysed. Forty-eight patients with PD were evaluated into two groups, with and without RLS. Clinical characteristics assessed in both groups were age, gender, duration of PD, Hoehn and Yahr, and Schwab and England scales. Laboratory variables such as hemoglobin, s-iron, s-ferritin and creatinine were obtained. The prevalence of RLS was 18.75%. No significant differences regarding clinical variables and biochemical parameters were observed. The high prevalence of RLS found in PD patients suggests the concept of a common etiological link and it seems that secondary causes did not play a central role in the pathophysiology of RLS in this group of parkinsonian patients
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