71 research outputs found

    Finishing the euchromatic sequence of the human genome

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    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

    In-Flight icing simulation capabilities of NRC's altitude icing wind tunnel

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    AIAA 2001 0094: An overview of the icing cloud characteristics needed to simulate in-flight icing is presented. The wider range of conditions that result from the need to test at sub-scale conditions in a wind tunnel are shown to create additional challenges for icing wind tunnels, over and above those that are encountered in nature. A detailed description of the NRC Altitude Icing Wind Tunnel (AIWT) is presented, providing background information for the discussion of recent calibrations, flow quality surveys and icing cloud investigations. The instrumentation used for these studies is described and individual measurement uncertainties are documented. The aerodynamic calibration began with measurements of total and static pressure corrections. This was followed by planar surveys of the flow quality in the test section. The calibrations were conducted at sea-level conditions. The effects on test section flow quality of spraying air through the settling chamber spray bars are documented. Spray air generally impacts the flow quality by modifying the velocity uniformity and flow angularity. Surveys of the icing cloud consisted of droplet size calibration, liquid water content (LWC) uniformity and LWC calibration. From these studies, it was found that the AIWT has acceptable LWC uniformity. New spray bars, under development at this time, should improve the icing cloud uniformity even further. Preliminary investigations of a single prototype spray bar in the AIWT show improved spray on-off transients and greater uniformity in LWC distribution. Future investigations are planned to identify the cause of reduced flow quality near the starboard wall of the test section.Peer reviewed: YesNRC publication: Ye

    Ventilatory response to forward acceleration

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    Philanthropic Experimentation: George Vanderbilt, the YMI, and Racial Uplift Ideology in Asheville, North Carolina, 1892-1906

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    After the Civil War the African American population in the southern Appalachia city of Asheville experienced significant growth. Drawn by the city’s tourism and hospitality industry, African Americans became important to the city’s service sector economy. Nevertheless, racism ensured their continued isolation from the city’s mainstream. Even before the advent of de facto segregation, African Americans were pushed to the margins, especially politically. This political marginalization made challenging the economic and social status quo difficult, and thus African Americans turned inward, focusing on the development of such key institutions as their churches and schools. Another organization that was important to the development of Asheville’s African American community was the Young Men’s Institute (YMI) in 1892. Central to the YMI’s mission was the development of the “social, moral, and Christian character” of young black men. As a key component of the black racial uplift ideology of the late nineteenth century, this paper will explore the creation of the YMI and the use of uplift ideology as a tool of resistance and protest in urban Appalachia. The paper will also examine how this ideology, which was really a project of the elite, unwittingly contributed to class divisions within the African American community itself
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