3 research outputs found
Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores
Nanopore sensors embedded within
thin dielectric membranes have
been gaining significant interest due to their single molecule sensitivity
and compatibility of detecting a large range of analytes, from DNA
and proteins, to small molecules and particles. Building on this concept
we utilize a metallic Au solid-state membrane to translocate and rapidly
detect single Au nanoparticles (NPs) functionalized with 589 dye molecules
using surface-enhanced resonance Raman spectroscopy (SERRS). We show
that, due to the plasmonic coupling between the Au metallic nanopore
surface and the NP, signal intensities are enhanced when probing analyte
molecules bound to the NP surface. Although not single molecule, this
nanopore sensing scheme benefits from the ability of SERRS to provide
rich vibrational information on the analyte, improving on current
nanopore-based electrical and optical detection techniques. We show
that the full vibrational spectrum of the analyte can be detected
with ultrahigh spectral sensitivity and a rapid temporal resolution
of 880 μs