Surface integrity of Mg-based nanocomposite produced by Abrasive Water Jet Machining (AWJM)

This paper investigates the influence of jet traverse speed on the surface integrity of 0.66 wt% Al2O3 nanoparticle reinforced metal matrix composite (MMC) generated by Abrasive Water Jet Machining (AWJM). Surface morphology, surface topography, and surface roughness (SR) of the AWJ surface were analyzed. The machined surfaces of the nanocomposites were examined by laser confocal microscope and field emission scanning electron microscope (FESEM). Microhardness and elasticity modulus measurement by nanoindentation testing were also performed across thickness of the samples to see depth of the zone, affected by AWJ cutting. The result reveals that extent of grooving by abrasive particle and irregularity in AWJ machined surface increases as the traverse speed increased. Similarly, the rise in value of surface roughness parameters with traverse speed was also seen. In addition, nanoindentation testing represents the lower hardness and elastic modulus due to softening occurs in AWJ surface

Exploring planetary magnetic environments using magnetically unclean spacecraft: a systems approach to VEX MAG data analysis

In situ measurements of the magnetic field are vital to the study of many fundamental problems in planetary research. Therefore the magnetometer experiment is a key element of the payload of Venus Express. In addition to the interaction of the solar wind with Venus, these measurements are crucial for the study of atmospheric escape and detection of lightning. However, the methodology for the magnetic field measurements had to be different to the traditional approach, because Venus Express is not a magnetically clean spacecraft. A technique based on two-point simultaneous measurements of the magnetic field and systems identification software is used to separate the natural magnetic field from the spacecraft generated interference. In this paper an overview of the techniques developed to separate these two field types and the results achieved for 1 Hz Venus Express data are presented. Previous publications suggest that the resulting Venus Express cleaned data is of comparable quality to measurements made from onboard magnetically clean spacecraft (Zhang et al., 2008a, b; Slavin et al., 2009)

Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations

Abstract Here we summarized what is known at the present about function, structure and effect of mutations in the human prolidase. Among the peptidases, prolidase is the only metalloenzyme that cleaves the iminodipeptides containing a proline or hydroxyproline residue at the C-terminal end. It is relevant in the latest stage of protein catabolism, particularly of those molecules rich in imino acids such as collagens, thus being involved in matrix remodelling. Beside its intracellular functions, prolidase has an antitoxic effect against some organophosphorus molecules, can be used in dietary industry as bitterness reducing agent and recently has been used as target enzyme for specific melanoma prodrug activation. Recombinant human prolidase was produced in prokaryotic and eukaryotic hosts with biochemical properties similar to the endogenous enzyme and represents a valid tool both to better understand the structure and biological function of the enzyme and to develop an enzyme replacement therapy for the prolidase deficiency (PD). Prolidase deficiency is a rare recessive disorder caused by mutations in the prolidase gene and characterized by severe skin lesions. Single amino acid substitutions, exon splicing, deletions and a duplication were described as causative for the disease and are mainly located at highly conserved amino acids in the sequence of prolidase from different species. The pathophysiology of PD is still poorly understood; we offer here a review of the molecular mechanisms so far hypothesized