352 research outputs found
Drastic fall-off of the thermal conductivity for disordered lattices in the limit of weak anharmonic interactions
We study the thermal conductivity, at fixed positive temperature, of a
disordered lattice of harmonic oscillators, weakly coupled to each other
through anharmonic potentials. The interaction is controlled by a small
parameter . We rigorously show, in two slightly different setups,
that the conductivity has a non-perturbative origin. This means that it decays
to zero faster than any polynomial in as . It
is then argued that this result extends to a disordered chain studied by Dhar
and Lebowitz, and to a classical spins chain recently investigated by
Oganesyan, Pal and Huse.Comment: 21 page
Energy transport through rare collisions
We study a one-dimensional hamiltonian chain of masses perturbed by an energy
conserving noise. The dynamics is such that, according to its hamiltonian part,
particles move freely in cells and interact with their neighbors through
collisions, made possible by a small overlap of size between
near cells. The noise only randomly flips the velocity of the particles. If
, and if time is rescaled by a factor ,
we show that energy evolves autonomously according to a stochastic equation,
which hydrodynamic limit is known in some cases. In particular, if only two
different energies are present, the limiting process coincides with the simple
symmetric exclusion process.Comment: 24 pages, 2 figure
Binding of soluble fibronectin to integrin α5ß1 - link to focal adhesion redistribution and contractile shape
Focal adhesions are randomly distributed across the ventral surface or along the edge of epithelial cells. In fibroblasts they orient centripetally and concentrate at a few peripheral sites connecting long F-actin stress fibers, causing a typical elongated, contractile morphology. Extensive remodeling of adhesions in fibroblasts also takes part in fibronectin fibrillogenesis, a process that depends on Rho-mediated contractility and results in the formation of a fibronectin matrix. Our current study shows that all these fibroblast characteristics are controlled by the ability of integrin alpha 5 beta 1 to bind soluble fibronectin molecules in their compact inactive conformation. The hypervariable region of the ligand-binding I-like domain of integrin alpha 5 beta 1 supports binding of soluble fibronectin. This supports the distribution of centripetally orientated focal adhesions in distinct peripheral sites, Rho activation and fibronectin fibrillogenesis through a mechanism that does not depend on Syndecan-4. Integrin alpha v beta 3, even when locked in high affinity conformations for the RGD recognition motif shows no appreciable binding of soluble fibronectin and, consequently, fails to support the typical fibroblast focal adhesion distribution, Rho activity and fibronectin fibrillogenesis in the absence of integrin alpha 5 beta 1. The ability of alpha 5 beta 1 integrin to interact with soluble fibronectin may thus drive the cell-matrix adhesion and cytoskeletal organization required for a contractile, fibroblast-like morphology, perhaps explaining why alpha 5 beta 1 integrin, similarly to fibronectin, is essential for development.Toxicolog
How Close is too Close? The Effect of a Non-Lethal Electric Shark Deterrent on White Shark Behaviour
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Sharks play a vital role in the health of marine ecosystems, but the potential threat that sharks pose to humans is a reminder of our vulnerability when entering the ocean. Personal shark deterrents are being marketed as the solution to mitigate the threat that sharks pose. However, the effectiveness claims of many personal deterrents are based on our knowledge of shark sensory biology rather than robust testing of the devices themselves, as most have not been subjected to independent scientific studies. Therefore, there is a clear need for thorough testing of commercially available shark deterrents to provide the public with recommendations of their effectiveness. Using a modified stereo-camera system, we quantified behavioural interactions between white sharks (Carcharodon carcharias) and a baited target in the presence of a commercially available, personal electric shark deterrent (Shark Shield Freedom7™). The stereo-camera system enabled an accurate assessment of the behavioural responses of C. carcharias when encountering a non-lethal electric field many times stronger than what they would naturally experience. Upon their first observed encounter, all C. carcharias were repelled at a mean (± std. error) proximity of 131 (± 10.3) cm, which corresponded to a mean voltage gradient of 9.7 (± 0.9) V/m. With each subsequent encounter, their proximity decreased by an average of 11.6 cm, which corresponded to an increase in tolerance to the electric field by an average of 2.6 (± 0.5) V/m per encounter. Despite the increase in tolerance, sharks continued to be deterred from interacting for the duration of each trial when in the presence of an active Shark Shield™. Furthermore, the findings provide no support to the theory that electric deterrents attract sharks. The results of this study provide quantitative evidence of the effectiveness of a non-lethal electric shark deterrent, its influence on the behaviour of C. carcharias, and an accurate method for testing other shark deterrent technologies
Effective treatment of edema and endothelial barrier dysfunction with imatinib
Background-Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific therapy. In a recent case report, we described fast resolution of pulmonary edema on treatment with the tyrosine kinase inhibitor imatinib through an unknown mechanism. Here, we explored the effect of imatinib on endothelial barrier dysfunction and edema formation. Methods and Results-We evaluated the effect of imatinib on endothelial barrier function in vitro and in vivo. In human macro- and microvascular endothelial monolayers, imatinib attenuated endothelial barrier dysfunction induced by thrombin and histamine. Small interfering RNA knock-downs of the imatinib-sensitive kinases revealed that imatinib attenuates endothelial barrier dysfunction via inhibition of Abl-related gene kinase (Arg/Abl2), a previously unknown mediator of endothelial barrier dysf Conclusions-Thus, imatinib prevents endothelial barrier dysfunction and edema formation via inhibition of Arg. These findings identify imatinib as a promising approach to permeability edema and indicate Arg as novel target for edema treatment. (Circulation. 2012;126:2728-2738.
Thermal conductivity in harmonic lattices with random collisions
We review recent rigorous mathematical results about the macroscopic
behaviour of harmonic chains with the dynamics perturbed by a random exchange
of velocities between nearest neighbor particles. The random exchange models
the effects of nonlinearities of anharmonic chains and the resulting dynamics
have similar macroscopic behaviour. In particular there is a superdiffusion of
energy for unpinned acoustic chains. The corresponding evolution of the
temperature profile is governed by a fractional heat equation. In non-acoustic
chains we have normal diffusivity, even if momentum is conserved.Comment: Review paper, to appear in the Springer Lecture Notes in Physics
volume "Thermal transport in low dimensions: from statistical physics to
nanoscale heat transfer" (S. Lepri ed.
Effects of an electric field on white sharks: in situ testing of an electric deterrent
Elasmobranchs can detect minute electromagnetic fields, <1 nV cm(-1), using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks.Charlie Huveneers, Paul J. Rogers, Jayson M. Semmens, Crystal Beckmann, Alison A. Kock, Brad Page, Simon D. Goldsworth
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