Comparison of maternal age-specific rates for common autosomal trisomies (trisomies 21, 18 and 13) and aneuploidies per 1,000 fetuses and live births in various age groups from various studies.

<p>Comparison of maternal age-specific rates for common autosomal trisomies (trisomies 21, 18 and 13) and aneuploidies per 1,000 fetuses and live births in various age groups from various studies.</p

Maternal Age-Specific Rates for Trisomy 21 and Common Autosomal Trisomies in Fetuses from a Single Diagnostic Center in Thailand

<div><p>To provide maternal age-specific rates for trisomy 21 (T21) and common autosomal trisomies (including trisomies 21, 18 and 13) in fetuses. We retrospectively reviewed prenatal cytogenetic results obtained between 1990 and 2009 in Songklanagarind Hospital, a university teaching hospital, in southern Thailand. Maternal age-specific rates of T21 and common autosomal trisomies were established using different regression models, from which only the fittest models were used for the study. A total of 17,819 records were included in the statistical analysis. The fittest models for predicting rates of T21 and common autosomal trisomies were regression models with 2 parameters (Age and Age²). The rate of T21 ranged between 2.67 per 1,000 fetuses at the age of 34 and 71.06 per 1,000 at the age of 48. The rate of common autosomal trisomies ranged between 4.54 per 1,000 and 99.65 per 1,000 at the same ages. This report provides the first maternal age-specific rates for T21 and common autosomal trisomies fetuses in a Southeast Asian population and the largest case number of fetuses have ever been reported in Asians.</p></div

Comparison of maternal age-specific rates of trisomy 21 per 1,000 fetuses and live births in various age groups from various studies.

<p>Comparison of maternal age-specific rates of trisomy 21 per 1,000 fetuses and live births in various age groups from various studies.</p

Number of cases eligible for statistical analysis in each age group.

<p>Observed numbers of cases with common autosomal trisomies (trisomies 21, 18 and 13) and predicted maternal age-specific rates in each age group (at the time of amniocentesis).</p