7,451 research outputs found
The impact of new neutrino DIS and Drell-Yan data on large-x parton distributions
New data sets have recently become available for neutrino and antineutrino
deep inelastic scattering on nuclear targets and for inclusive dimuon
production in pp pd interactions. These data sets are sensitive to different
combinations of parton distribution functions in the large-x region and,
therefore, provide different constraints when incorporated into global parton
distribution function fits. We compare and contrast the effects of these new
data on parton distribution fits, with special emphasis on the effects at large
x. The effects of the use of nuclear targets in the neutrino and antineutrino
data sets are also investigated.Comment: 24 pages, 13 figure
Huddle test measurement of a near Johnson noise limited geophone
In this paper, the sensor noise of two geophone configurations (L-22D and L-4C geophones from Sercel with custom built amplifiers) was measured by performing two huddle tests. It is shown that the accuracy of the results can be significantly improved by performing the huddle test in a seismically quiet environment and by using a large number of reference sensors to remove the seismic foreground signal from the data. Using these two techniques, the measured sensor noise of the two geophone configurations matched the calculated predictions remarkably well in the bandwidth of interest (0.01 Hz–100 Hz). Low noise operational amplifiers OPA188 were utilized to amplify the L-4C geophone to give a sensor that was characterized to be near Johnson noise limited in the bandwidth of interest with a noise value of 10−11 m/Hz⎯⎯⎯⎯⎯√10−11 m/Hz at 1 Hz
Generic User Process Interface for Event Generators
Generic Fortran common blocks are presented for use by High Energy Physics
event generators for the transfer of event configurations from parton level
generators to showering and hadronization event generators.Comment: Physics at TeV Colliders II Workshop, Les Houches, France, May 2001
14 pages, 6 figure
Implications of Hadron Collider Observables on Parton Distribution Function Uncertainties
Standard parton distribution function sets do not have rigorously quantified
uncertainties. In recent years it has become apparent that these uncertainties
play an important role in the interpretation of hadron collider data. In this
paper, using the framework of statistical inference, we illustrate a technique
that can be used to efficiently propagate the uncertainties to new observables,
assess the compatibility of new data with an initial fit, and, in case the
compatibility is good, include the new data in the fit.Comment: 22 pages, 5 figure
Transport equations for the inflationary trispectrum
We use transport techniques to calculate the trispectrum produced in
multiple-field inflationary models with canonical kinetic terms. Our method
allows the time evolution of the local trispectrum parameters, tauNL and gNL,
to be tracked throughout the inflationary phase. We illustrate our approach
using examples. We give a simplified method to calculate the superhorizon part
of the relation between field fluctuations on spatially flat hypersurfaces and
the curvature perturbation on uniform density slices, and obtain its
third-order part for the first time. We clarify how the 'backwards' formalism
of Yokoyama et al. relates to our analysis and other recent work. We supply
explicit formulae which enable each inflationary observable to be computed in
any canonical model of interest, using a suitable first-order ODE solver.Comment: 24 pages, plus references and appendix. v2: matches version published
in JCAP; typo fixed in Eq. (54
Optical Microscopy and Atomic Force Microscopy Imaging of 2,4,6-Trinitrotoluene Droplets and Clusters on Mica
Optical and atomic force microscopy (AFM) were used to image 2,4,6-trinitrotoluene (TNT) on a cleaved mica (001) surface. The vapor deposition of TNT resulted in ellipsoidal drop formation on the mica surface. The growth rate of the drop diameter was found to be linear with vapor dosing time while the drop density followed a 1/r2 dependence, where r is the length of the major axis of the ellipsoid, for increasing dosing times. TNT platelets surrounded by a region depleted of drops were observed after 8 hours of dosing. The depleted region is attributed to a 10% shrinkage for liquid-solid transition for TNT and also from the enthalpy of fusion which causes the vaporization of small drops and clusters of TNT. Residues of TNT located in the depleted regions were characterized by AFM lift-off forces and were attributed to different morphologies of TNT that nucleated at different sites on the mica surface or dinitro- and trinitro-benzene derivatives which are common impurities in 2,4,6-trinitrotoluene
Unique Residues Involved in Activation of the Multitasking Protease/Chaperone HtrA from Chlamydia trachomatis
DegP, a member of the HtrA family of proteins, conducts critical bacterial protein quality control by both chaperone and proteolysis activities. The regulatory mechanisms controlling these two distinct activities, however, are unknown. DegP activation is known to involve a unique mechanism of allosteric binding, conformational changes and oligomer formation. We have uncovered a novel role for the residues at the PDZ1:protease interface in oligomer formation specifically for chaperone substrates of Chlamydia trachomatis HtrA (DegP homolog). We have demonstrated that CtHtrA proteolysis could be activated by allosteric binding and oligomer formation. The PDZ1 activator cleft was required for the activation and oligomer formation. However, unique to CtHtrA was the critical role for residues at the PDZ1:protease interface in oligomer formation when the activator was an in vitro chaperone substrate. Furthermore, a potential in vivo chaperone substrate, the major outer membrane protein (MOMP) from Chlamydia, was able to activate CtHtrA and induce oligomer formation. Therefore, we have revealed novel residues involved in the activation of CtHtrA which are likely to have important in vivo implications for outer membrane protein assembly
Koala cathelicidin PhciCath5 has antimicrobial activity, including against Chlamydia pecorum.
Devastating fires in Australia over 2019-20 decimated native fauna and flora, including koalas. The resulting population bottleneck, combined with significant loss of habitat, increases the vulnerability of remaining koala populations to threats which include disease. Chlamydia is one disease which causes significant morbidity and mortality in koalas. The predominant pathogenic species, Chlamydia pecorum, causes severe ocular, urogenital and reproductive tract disease. In marsupials, including the koala, gene expansions of an antimicrobial peptide family known as cathelicidins have enabled protection of immunologically naïve pouch young during early development. We propose that koala cathelicidins are active against Chlamydia and other bacteria and fungi. Here we describe ten koala cathelicidins, five of which contained full length coding sequences that were widely expressed in tissues throughout the body. Focusing on these five, we investigate their antimicrobial activity against two koala C. pecorum isolates from distinct serovars; MarsBar and IPTaLE, as well as other bacteria and fungi. One cathelicidin, PhciCath5, inactivated C. pecorum IPTaLE and MarsBar elementary bodies and significantly reduced the number of inclusions compared to the control (p<0.0001). Despite evidence of cathelicidin expression within tissues known to be infected by Chlamydia, natural PhciCath5 concentrations may be inadequate in vivo to prevent or control C. pecorum infections in koalas. PhciCath5 also displayed antimicrobial activity against fungi and Gram negative and positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Electrostatic interactions likely drive PhciCath5 adherence to the pathogen cell membrane, followed by membrane permeabilisation leading to cell death. Activity against E. coli was reduced in the presence of 10% serum and 20% whole blood. Future modification of the PhciCath5 peptide to enhance activity, including in the presence of serum/blood, may provide a novel solution to Chlamydia infection in koalas and other species
Examination of direct-photon and pion production in proton-nucleon collisions
We present a study of inclusive direct-photon and pion production in hadronic
interactions, focusing on a comparison of the ratio of gamma/pi0 yields with
expectations from next-to-leading order perturbative QCD (NLO pQCD). We also
examine the impact of a phenomenological model involving k_T smearing (which
approximates effects of additional soft-gluon emission) on absolute predictions
for photon and pion production and their ratio.Comment: 20 pages, 12 figures. Minor changes in wording and in figure
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