Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients.

To our knowledge, this is the largest study evaluating relationships between 3T Magnetic Resonance Imaging (MRI) and P300 and memory/cognitive tests in the literature. The 3T MRI using NeuroQuant has an increased resolution 15 times that of 1.5T MRI. Utilizing NeuroQuant 3T MRI as a diagnostic tool in primary care, subjects (N=169; 19-90 years) displayed increased areas of anatomical atrophy: 34.62% hippocampal atrophy (N=54), 57.14% central atrophy (N=88), and 44.52% temporal atrophy (N=69). A majority of these patients exhibited overlap in measured areas of atrophy and were cognitively impaired. These results positively correlated with decreased P300 values and WMS-III (WMS-III) scores differentially across various brain loci. Delayed latency (p=0.0740) was marginally associated with temporal atrophy; reduced fractional anisotropy (FA) in frontal lobes correlated with aging, delayed P300 latency, and decreased visual and working memory (p=0.0115). Aging and delayed P300 latency correlated with lower FA. The correlation between working memory and reduced FA in frontal lobes is marginally significant (p=0.0787). In the centrum semiovale (CS), reduced FA correlated with visual memory (p=0.0622). Lower demyelination correlated with higher P300 amplitude (p=0.0002). Compared to males, females have higher demyelination (p=0.0064). Along these lines, the higher the P300 amplitude, the lower the bilateral atrophy (p=0.0165). Hippocampal atrophy correlated with increased auditory memory and gender, especially in males (p=0.0087). In considering temporal lobe atrophy correlations: delayed P300 latency and high temporal atrophy (p=0.0740); high auditory memory and low temporal atrophy (p=0.0417); and high working memory and low temporal atrophy (p=0.0166). Central atrophy correlated with aging and immediate memory (p=0.0294): the higher the immediate memory, the lower the central atrophy. Generally, the validation of brain atrophy by P300 and WMS-III could lead to cost-effective methods utilizable in primary care medicine following further confirmation

NeuroQuant Information.

<p>NeuroQuant Information.</p

Logistic Regression Model for Concussion (ROC Curve: AUC = 0.647).

<p>Logistic Regression Model for Concussion (ROC Curve: AUC = 0.647).</p

P300 values in normal vs. cognitively impaired; (4a) Normal P300 (Latency = 320 ms; Amplitude = 10 μv; Deficiency Present = none); (4b) Abnormal P300 (Latency = 375 ms (delayed); Amplitude = 0.5 μv (decreased); Deficiency Present = yes).

<p>P300 values in normal vs. cognitively impaired; (4a) Normal P300 (Latency = 320 ms; Amplitude = 10 μv; Deficiency Present = none); (4b) Abnormal P300 (Latency = 375 ms (delayed); Amplitude = 0.5 μv (decreased); Deficiency Present = yes).</p

Logistic Regression Model for Central Atrophy (ROC Curve: AUC = 0.621).

<p>Logistic Regression Model for Central Atrophy (ROC Curve: AUC = 0.621).</p

Logistic Regression Model for Temporal Atrophy (ROC Curve: AUC = 0.685).

<p>Logistic Regression Model for Temporal Atrophy (ROC Curve: AUC = 0.685).</p

Logistic Regression Model for Hippocampal Atrophy (ROC Curve: AUC = 0.638).

<p>Logistic Regression Model for Hippocampal Atrophy (ROC Curve: AUC = 0.638).</p

Logistic Regression Model for Small Vessel Ischemia (ROC Curve: AUC = 0.740).

<p>Logistic Regression Model for Small Vessel Ischemia (ROC Curve: AUC = 0.740).</p

3T MRI Information.

<p>3T MRI Information.</p

WMS Scores.

<p>WMS Scores.</p