Circulating organokines in coronary artery disease and metabolic syndrome: FABP4, adiponectin, irisin, FSTL1

Cardiovascular disorders are closely linked to metabolic syndrome and remain a leading cause of mortality worldwide, despite advances in early detection and treatment. Adipokines, cardiokines, and myokines play critical roles in maintaining systemic metabolic homeostasis. In this study, we measured serum levels of fatty acid binding protein 4 (FABP4), follistatin-like 1 (FSTL1), irisin, and adiponectin in 243 male patients undergoing elective coronary angiography. We investigated the associations of these biomarkers with coronary artery disease (CAD) and their correlation with metabolic syndrome status. FSTL1 levels were predicted using a Particle Swarm Optimization-enhanced Adaptive Neuro-Fuzzy Inference System (PSO-ANFIS) based on artificial intelligence. Patients with CAD exhibited significantly lower FABP4 levels (p<0.0001), and low FABP4 levels emerged as an independent predictor of CAD in logistic regression analysis (odds ratio 0.903, 95% CI 0.825-0.987, p=0.025). The combination of adiponectin, FSTL1, and irisin as a biomarker strategy demonstrated high sensitivity and specificity for diagnosing metabolic syndrome (AUC = 0.92, 95% CI 0.88-0.96). Both FSTL1 and adiponectin independently correlated with metabolic syndrome (p<0.001, odds ratio 1.039, 95% CI 1.025-1.054; p<0.001, odds ratio 0.979, 95% CI 0.971-0.988, respectively). The prediction of FSTL1 levels using PSO-ANFIS supports the concept of harmonization among metabolic messengers. These findings underscore the potential of FABP4 and FSTL1 as valuable biomarkers for diagnosing metabolic and cardiovascular diseases, thereby facilitating personalized interventions targeting organokine pathways

Control of the flow in the annular region of a shrouded cylinder with splitter plate

In the present study, the flow control with a splitter plate was studied considering the annular region of a shrouded cylinder. The effect of splitter plate angle, α which was defined according to the cylinder centreline is investigated experimentally in deep water using Particle image Velocimetry (PIV) technique and flow visualization by dye injection method. The range of splitter plate angle was selected within 60°≤ α ≤180° with an increment of 30°. The porosity of the shroud which is a perforated cylinder was selected as β=0.7 in order to have larger fluid entrainment through the cylinder. The results were compared with the no-plate case and showed that the splitter plate located in the annular region of shrouded cylinders is effective on reducing the turbulence levels just behind the cylinder base, as well as the near wake of the perforated shroud

The effects of perforated cylinders on the vortex shedding on the suppression of a circular cylinder

The aim of this study is the control of unsteady vortical flow occurred downstream of a circular cylinder located in shallow water flow using concentrically located outer perforated cylinder. The porosities, β have been changed between 0.1 and 0.8 in the present study. The increments of porosity β were taken as 0.05 in the range of 0.1 and 0.8 with a hole diameter of d=10 mm. The ratio of inner cylinder diameter to outer cylinder diameter, Di/Do was selected as 0.25, 0.3, 0.4, 0.5 and 0.6 the inner cylinder diameter is Di=50mm where the outer cylinder diameter is Dd=100mm. Experiments were performed at a constant depth of the water level as h=50mm (half of the outer cylinder diameter). Free stream velocity was taken as U∞=100 mm/s corresponding to a Reynolds number of Re Do=10000 based on the outer cylinder diameter. It has been observed that the inner circular cylinder was highly affected by the existence of surrounding outer perforated cylinders. It is observed that the intensity of Reynolds shear stress correlating, is completely attenuated in the region both downstream of concentric cylinder and between the concentric cylinders. It is determined from the experiments that porosity, β=0.55 is the most effective parameter for control of flow structure that is occurred from the inner cylinder

Survival associated with the use of sentinel lymph node in addition to lymphadenectomy in early-stage cervical cancer treated with surgery alone: A sub-analysis of the Surveillance in Cervical CANcer (SCCAN) collaborative study

AIM: The aim of this study was to assess whether the use of sentinel lymph node (SLN) in addition to lymphadenectomy was associated with survival benefit in patients with early-stage cervical cancer. METHODS: International, multicenter, retrospective study. INCLUSION CRITERIA: cervical cancer treated between 01/2007 and 12/2016 by surgery only; squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, FIGO 2009 stage IB1-IIA2, negative surgical margins, and laparotomy approach. Patients undergoing neo-adjuvant and/or adjuvant treatment and/or with positive para-aortic lymph nodes, were excluded. Women with positive pelvic nodes who refused adjuvant treatment, were included. Lymph node assessment was performed by SLN (with ultrastaging protocol) plus pelvic lymphadenectomy ('SLN' group) or pelvic lymphadenectomy alone ('non-SLN' group). RESULTS: 1083 patients were included: 300 (27.7 %) in SLN and 783 (72.3 %) in non-SLN group. 77 (7.1 %) patients had recurrence (N = 11, 3.7 % SLN versus N = 66, 8.4 % non-SLN, p = 0.005) and 34 (3.1 %) (N = 4, 1.3 % SLN versus N = 30, 3.8 % non-SLN, p = 0.033) died. SLN group had better 5-year disease-free survival (DFS) (96.0 %,95 %CI:93.5-98.5 versus 92.0 %,95 %CI:90.0-94.0; p = 0.024). No 5-year overall survival (OS) difference was shown (98.4 %,95 %CI:96.8-99.9 versus 96.8 %,95 %CI:95.4-98.2; p = 0.160). SLN biopsy and lower stage were independent factors associated with improved DFS (HR:0.505,95 %CI:0.266-0.959, p = 0.037 and HR:2.703,95 %CI:1.389-5.261, p = 0.003, respectively). Incidence of pelvic central recurrences was higher in the non-SLN group (1.7 % versus 4.5 %, p = 0.039). CONCLUSION: Adding SLN biopsy to pelvic lymphadenectomy was associated with lower recurrence and death rate and improved 5-year DFS. This might be explained by the lower rate of missed nodal metastasis thanks to the use of SLN ultrastaging. SLN biopsy should be recommended in patients with early-stage cervical cancer

Vortex Shedding Control Using a Permeable Plate Located Around the Separation Point of a Circular Cylinder

The flow downstream of a plain cylinder with attached permeable plates having various porosity ratios was investigated experimentally using both Particle Image Velocimetry (PIV) and dye visualization techniques to control the vortex shedding around the circular cylinder. The diameter of the cylinder and length to diameter ratio of the plate were kept constant as d= 50 mm and L/d=1.0, respectively. The porosity ratio, β which can be defined as the ratio of open area to the whole body surface area was taken as β=0.4, 0.5, 0.6, 0.7 and 0.8 (permeable plates). The study was performed considering deep water flow conditions and depth-averaged free stream velocity was taken constant as U = 95.2mm/s which corresponded to a Reynolds number of Red = 5000 based on the cylinder diameter. The results of a plain cylinder were compared with the results of cylinder with permeable plates in order to understand the control effect. Both qualitative and quantitative results revealed that the plates are effective on the unsteady flow structure downstream of the cylinder, i.e. the vortex formation length was increased, turbulent statistics was reduced and both width and length of the wake were changed by usage of permeable plates attached around the separation point of the cylinder.</jats:p