The History and Practice of College Health

This volume is the first definitive reference and textbook in the one-hundred-fifty year history of college health. Written for professionals and for those working in student services and higher education administration, it covers the history of college health, administrative matters including financing and accreditation, and clinical issues such as women’s health, HIV/AIDS, and mental health. The book also focuses on prevention, including immunization and tuberculin testing. The contributors are well respected in the field and are actively working in the specific areas on which they write. H. Spencer Turner, MD, is director of the University Health Service and clinical professor of preventative medicine and environmental health at the University of Kentucky. Janet L. Hurley, Ph.D., is the Associate Director and Administrator of the University of Kentucky\u27s Health Service.https://uknowledge.uky.edu/upk_history_of_science_technology_and_medicine/1003/thumbnail.jp

The random case of Conley's theorem

The well-known Conley's theorem states that the complement of chain recurrent set equals the union of all connecting orbits of the flow $\phi$ on the compact metric space $X$, i.e. $X-\mathcal{CR}(\phi)=\bigcup [B(A)-A]$, where $\mathcal{CR}(\phi)$ denotes the chain recurrent set of $\phi$, $A$ stands for an attractor and $B(A)$ is the basin determined by $A$. In this paper we show that by appropriately selecting the definition of random attractor, in fact we define a random local attractor to be the $\omega$-limit set of some random pre-attractor surrounding it, and by considering appropriate measurability, in fact we also consider the universal $\sigma$-algebra $\mathcal F^u$-measurability besides $\mathcal F$-measurability, we are able to obtain the random case of Conley's theorem.Comment: 15 page

SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis.

Hereditary spastic paraplegias (HSPs, SPG1-46) are inherited neurological disorders characterized by lower extremity spastic weakness. Loss-of-function SPG20 gene mutations cause an autosomal recessive HSP known as Troyer syndrome. The SPG20 protein spartin localizes to lipid droplets and endosomes, and it interacts with tail interacting protein 47 (TIP47) as well as the ubiquitin E3 ligases atrophin-1-interacting protein (AIP)4 and AIP5. Spartin harbors a domain contained within microtubule-interacting and trafficking molecules (MIT) at its N-terminus, and most proteins with MIT domains interact with specific ESCRT-III proteins. Using yeast two-hybrid and in vitro surface plasmon resonance assays, we demonstrate that the spartin MIT domain binds with micromolar affinity to the endosomal sorting complex required for transport (ESCRT)-III protein increased sodium tolerance (Ist)1 but not to ESCRT-III proteins charged multivesicular body proteins 1-7. Spartin colocalizes with Ist1 at the midbody, and depletion of Ist1 in cells by small interfering RNA significantly decreases the number of cells where spartin is present at midbodies. Depletion of spartin does not affect Ist1 localization to midbodies but markedly impairs cytokinesis. A structure-based amino acid substitution in the spartin MIT domain (F24D) blocks the spartin-Ist1 interaction. Spartin F24D does not localize to the midbody and acts in a dominant-negative manner to impair cytokinesis. These data suggest that Ist1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis

A pertubative approach to the Kondo effect in magnetic atoms on nonmagnetic substrates

Recent experimental advances in scanning tunneling microscopy make the measurement of the conductance spectra of isolated and magnetically coupled atoms on nonmagnetic substrates possible. Notably these spectra are characterized by a competition between the Kondo effect and spin-flip inelastic electron tunneling. In particular they include Kondo resonances and a logarithmic enhancement of the conductance at voltages corresponding to magnetic excitations, two features that cannot be captured by second order perturbation theory in the electron-spin coupling. We have now derived a third order analytic expression for the electron-spin self-energy, which can be readily used in combination with the non-equilibrium Green's function scheme for electron transport at finite bias. We demonstrate that our method is capable of quantitative description the competition between Kondo resonances and spin-flip inelastic electron tunneling at a computational cost significantly lower than that of other approaches. The examples of Co and Fe on CuN are discussed in detail

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.

Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-specific stimulator YC-1 induce a 71° rotation of the heme-binding β H-NOX and PAS domains. Repositioning of the β H-NOX domain leads to a straightening of the coiled-coil domains, which, in turn, use the motion to move the catalytic domains into an active conformation. YC-1 binds directly between the β H-NOX domain and the two CC domains. The structural elongation of the particle observed in cryo-EM was corroborated in solution using small angle X-ray scattering (SAXS). These structures delineate the endpoints of the allosteric transition responsible for the major cyclic GMP-dependent physiological effects of NO

X-Ray Light Curves of Gamma-ray Bursts Detected with the All-Sky Monitor on RXTE

We present X-ray light curves (1.5-12 keV) for fifteen gamma-ray bursts (GRBs) detected by the All-Sky Monitor on the Rossi X-ray Timing Explorer. We compare these soft X-ray light curves with count rate histories obtained by the high-energy (>12 keV) experiments BATSE, Konus-Wind, the BeppoSAX Gamma-Ray Burst Monitor, and the burst monitor on Ulysses. We discuss these light curves within the context of a simple relativistic fireball and synchrotron shock paradigm, and we address the possibility of having observed the transition between a GRB and its afterglow. The light curves show diverse morphologies, with striking differences between energy bands. In several bursts, intervals of significant emission are evident in the ASM energy range with little or no corresponding emission apparent in the high-energy light curves. For example, the final peak of GRB 970815 as recorded by the ASM is only detected in the softest BATSE energy bands. We also study the duration of bursts as a function of energy. Simple, singly-peaked bursts seem consistent with the E^{-0.5} power law expected from an origin in synchrotron radiation, but durations of bursts that exhibit complex temporal structure are not consistent with this prediction. Bursts such as GRB 970828 that show many short spikes of emission at high energies last significantly longer at low energies than the synchrotron cooling law would predict.Comment: 15 pages with 20 figures and 2 tables. In emulateapj format. Accepted by ApJ

LOTIS Search for Early Time Optical Afterglows: GRB 971227

We report on the very early time search for an optical afterglow from GRB 971227 with the Livermore Optical Transient Imaging System (LOTIS). LOTIS began imaging the `Original' BATSE error box of GRB 971227 approximately 14 s after the onset of gamma-ray emission. Continuous monitoring of the position throughout the evening yielded a total of 499 images (10 s integration). Analysis of these images revealed no steady optical afterglow brighter than R=12.3 +- 0.2 in any single image. Coaddition of different combinations of the LOTIS images also failed to uncover transient optical emission. In particular, assuming a constant early time flux, no optical afterglow brighter than R=14.2 +- 0.2 was present within the first 1200 s and no optical afterglow brighter than R=15.0 +- 0.2 was present in the first 6.0 h. Follow up observations by other groups revealed a likely X-ray afterglow and a possible optical afterglow. Although subsequent deeper observations could not confirm a fading source, we show that these transients are not inconsistent with our present knowledge of the characteristics of GRB afterglows. We also demonstrate that with the upgraded thermoelectrically cooled CCDs, LOTIS is capable of either detecting very early time optical afterglow or placing stringent constraints on the relationship between the gamma-ray emission and the longer wavelength afterglow in relativistic blast wave models.Comment: 17 pages, 3 eps figures, revisions based on reviewers comment

Gametogenic Cycle in the Non-Native Atlantic Surf Clam, Spisula solidissima (Dillwyn, 1817), Cultured in the Coastal Waters of Georgia

This study describes the gametogenic cycle of the Atlantic surf clam, Spisula solidissima (Dillwyn, 1817), cultured from fall to spring in the coastal waters of Georgia, where it is non-native. Early active stages of gametogenic development began in November, with the majority (83%) of the animals in the early active stage by December. Gonadal indices increased to late active stages by March, with ripe individuals present in April. Spawning commenced in May and continued into June. Sex ratio (0.48 female to 1.00 male) was significantly unequal. Results of this study indicate that clams achieved sexual maturity and spawned when cultured in the coastal waters of Georgia. An aquacultural enterprise in Georgia could obtain broodstock for the production of the following fall\u27s seed crop from the prior year\u27s growout field planted clams before their spring harvest

Advanced techniques for high resolution spectroscopic observations of cosmic gamma-ray sources

An advanced gamma-ray spectrometer that is currently in development is described. It will obtain a sensitivity of 0.0001 ph/sq cm./sec in a 6 hour balloon observation and uses innovative techniques for background reduction and source imaging