6 research outputs found
Review of Current Strategies for Delivering Alzheimer’s Disease Drugs across the Blood-Brain Barrier
Effective therapy for Alzheimer’s disease is a major challenge in the pharmaceutical sciences. There are six FDA approved drugs (e.g., donepezil, memantine) that show some effectiveness; however, they only relieve symptoms. Two factors hamper research. First, the cause of Alzheimer’s disease is not fully understood. Second, the blood-brain barrier restricts drug efficacy. This review summarized current knowledge relevant to both of these factors. First, we reviewed the pathophysiology of Alzheimer’s disease. Next, we reviewed the structural and biological properties of the blood-brain barrier. We then described the most promising drug delivery systems that have been developed in recent years; these include polymeric nanoparticles, liposomes, metallic nanoparticles and cyclodextrins. Overall, we aim to provide ideas and clues to design effective drug delivery systems for penetrating the blood-brain barrier to treat Alzheimer’s disease
Cryptotanshinone-Loaded Cerasomes Formulation: In Vitro Drug Release, in Vivo Pharmacokinetics, and in Vivo Efficacy for Topical Therapy of Acne
Cerasomes (CS), evolved
from liposomes, are novel drug-delivery
systems that have potential medical application as carriers for drugs
or active ingredients. Although many
studies have been conducted on the pharmaceutical and physicochemical
properties of CS, the role of CS in influencing the in vivo plasma
and topical pharmacokinetics and efficacy of topical drug delivery
remain unclear. In this context, we chose cryptotanshinone (CTS) as
a model drug for the preparation of CTS-CS by means of the ethanol
injection method to investigate their in vitro/in vivo drug-release
behavior and in vivo efficacy. (1) In in vitro studies, CTS-CS gel
was proven to be capable of achieving a higher permeation rate and
significant accumulation in the dermis of isolated rat skin using
Franz diffusion cells. (2) In
in vivo studies, microdialysis experiments used to measure the plasma
and topical pharmacokinetics demonstrated that the CS had a high drug
concentration, short peak time, and slow elimination. Meanwhile, the
plasma area under the concentration–time curve of CTS-CS gel
was less than half that for the CTS gel in 12 h, which indicates that
the drug bioavailability dramatically increased in the experiments.
(3) In in vivo efficacy studies, we duplicated a rat acne model and
performed antiacne efficacy experiments. The CTS-CS gel improved the
antiacne efficacy compared to that of ordinary CTS gel. Moreover,
it inhibited the expression of interleukin-1α and androgen receptors
effectively. All of these results show
that CTS-CS gel has significant potential for the treatment of acne
induced by inflammation and excessive secretion of androgen, suggesting
that CS formulations were designed as a good therapeutic option for
skin disease