Curvature and Acoustic Instabilities in Rotating Fluid Disks

The stability of a rotating fluid disk to the formation of spiral arms is studied in the tightwinding approximation in the linear regime. The dispersion relation for spirals that was derived by Bertin et al. is shown to contain a new, acoustic instability beyond the Lindblad resonances that depends only on pressure and rotation. In this regime, pressure and gravity exchange roles as drivers and inhibitors of spiral wave structures. Other instabilities that are enhanced by pressure are also found in the general dispersion relation by including higher order terms in the small parameter 1/kr for wavenumber k and radius r. These instabilities are present even for large values of Toomre's parameter Q. Unstable growth rates are determined in four cases: a self-gravitating disk with a flat rotation curve, a self-gravitating disk with solid body rotation, a non-self-gravitating disk with solid body rotation, and a non-self-gravitating disk with Keplerian rotation. The most important application appears to be as a source of spiral structure, possibly leading to accretion in non-self-gravitating disks, such as some galactic nuclear disks, disks around black holes, and proto-planetary disks. All of these examples have short orbital times so the unstable growth time can be small.Comment: 30 pages, 5 figures, scheduled for ApJ 520, August 1, 199

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy

BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing the need for robust and sensitive clinical trial platforms for evaluating their effectiveness in human patient cohorts. Given that most clinical trials for SMA are likely to involve young children, there is a need for validated molecular biomarkers to assist with monitoring disease progression and establishing the effectiveness of therapies being tested. Proteomics technologies have recently been highlighted as a potentially powerful tool for such biomarker discovery. METHODS: We utilized label-free proteomics to identify individual proteins in pathologically-affected skeletal muscle from SMA mice that report directly on disease status. Quantitative fluorescent western blotting was then used to assess whether protein biomarkers were robustly changed in muscle, skin and blood from another mouse model of SMA, as well as in a small cohort of human SMA patient muscle biopsies. RESULTS: By comparing the protein composition of skeletal muscle in SMA mice at a pre-symptomatic time-point with the muscle proteome at a late-symptomatic time-point we identified increased expression of both Calreticulin and GRP75/Mortalin as robust indicators of disease progression in SMA mice. We report that these protein biomarkers were consistently modified in different mouse models of SMA, as well as across multiple skeletal muscles, and were also measurable in skin biopsies. Furthermore, Calreticulin and GRP75/Mortalin were measurable in muscle biopsy samples from human SMA patients. CONCLUSIONS: We conclude that label-free proteomics technology provides a powerful platform for biomarker identification in SMA, revealing Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers capable of reporting on disease progression in samples of muscle and skin

Extended brief intervention to address alcohol misuse in people with mild to moderate intellectual disabilities living in the community (EBI-ID): study protocol for a randomised controlled trial.

There is some evidence that people with intellectual disabilities who live in the community are exposed to the same risks of alcohol use as the rest of the population. Various interventions have been evaluated in the general population to tackle hazardous or harmful drinking and alcohol dependence, but the literature evaluating interventions is very limited regarding intellectual disabilities. The National Institute for Health and Clinical Excellence recommends that brief and extended brief interventions be used to help young persons and adults who have screened as positive for hazardous and harmful drinking. The objective of this trial is to investigate the feasibility of adapting and delivering an extended brief intervention (EBI) to persons with mild/moderate intellectual disability who live in the community and whose level of drinking is harmful or hazardous

Elements of Proximal Formative Assessment in Learners’ Discourse about Energy

Proximal formative assessment, the just-in-time elicitation of students\u27 ideas that informs ongoing instruction, is usually associated with the instructor in a formal classroom setting. However, the elicitation, assessment, and subsequent instruction that characterize proximal formative assessment are also seen in discourse among peers. We present a case in which secondary teachers in a professional development course at SPU are discussing energy flow in refrigerators. In this episode, a peer is invited to share her thinking (elicitation). Her idea that refrigerators move heat from a relatively cold compartment to a hotter environment is inappropriately judged as incorrect (assessment). The instruction (peer explanation) that follows is based on the second law of thermodynamics, and acts as corrective rather than collaborative

Rainfall and runoff data for Hinkson and Grindstone creeks at Columbia, MO.

"A thesis for the degree of bachelor of science in civil engineering. University of Missouri, Department of Engineering, 1909.""The investigation presented in these notes has resulted more satisfactorily than was anticipated when the work was first undertaken. We feel perfectly satisfied with the results herewith submitted as far as they go, but regret that the period of investigation was not of sufficient duration to give more nearly average results, particularly in regard to the conditions during the summer months. In the preparation of this paper, we are especially indebted to Professor T. J. Rodhouse, in charge of the Hydraulic Engineering, University of Missouri, under whose supervision the work was carried out and whose counsel has guided us throughout the work. Our appreciation and thanks are justly due Mr. George Reeder, Director Missouri section, U.S.weather Bureau, who furnished the rainfall data, with other valuable information; to the members of the Engineering faculty in general, for their suggestions and assistance; and to the members of the senior Engineering class who have assisted in some of the field work."--Forewor