2,762 research outputs found

    DNA Methylation in Aggressive Gastric Carcinoma

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    High-Mobility Pentacene-Based Thin-Film Transistors With a Solution-Processed Barium Titanate Insulator

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    Abstract—Pentacene-based organic thin-film transistors (OTFTs) with solution-processed barium titanate (Ba1.2Ti0.8O3) as a gate insulator are demonstrated. The electrical properties of pentacene-based TFTs show a high field-effect mobility of 8.85 cm2 · V−1 · s−1, a low threshold voltage of −1.89 V, and a low subthreshold slope swing of 310 mV/decade. The chemical composition and binding energy of solution-processed barium titanate thin films are analyzed through X-ray photoelectron spectroscopy. The matching surface energy on the surface of the barium titanate thin film is 43.12 mJ · m−2, which leads to Stranski–Krastanov mode growth, and thus, high mobility is exhibited in pentacene-based TFTs. Index Terms—Barium titanate, high field-effect mobility, high permittivity, organic thin-filmtransistor (OTFT), solution process

    Hepatocellular carcinoma detected by regular surveillance: Does timely confirmation of diagnosis matter?

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    AbstractBackgroundAlthough current guidelines recommended surveillance of hepatocellular carcinoma, prognosis in patients undergoing enhanced follow-up has yet to be evaluated.AimsExamine outcomes of hepatocellular carcinoma diagnosed during enhanced follow-up.MethodsDuring 2010–2012, 194 patients underwent ultrasonography surveillance were diagnosed with hepatocellular carcinoma and divided into: (A) immediate diagnosis (N=105, 54.1%) after positive ultrasonography, (B) enhanced follow-up: (N=38, 19.6%) for initial negative recall procedures, (C) late call back: (N=28, 14.4%) recall procedures were deferred after positive ultrasonography, and (D) beyond ultrasonography: (N=23, 11.9%) surveillance ultrasonography had been negative.ResultsMedian time from positive ultrasonography to confirmation of hepatocellular carcinoma were 9.5 months (2–67) in the Group B and 6.5 months (3–44) in the Group C. Stage distribution and 3-year survival rates were similar amongst all Groups. Surveillance intervals longer than 6 months were associated with the non-curative stage (3.7% vs. 12.5%, p=0.04). Nine (4.6%) patients underwent surveillance were diagnosed as Barcelona-Clinic Liver Cancer stage C.ConclusionEnhanced follow-up by current guidelines is appropriate that treatment can be deferred until a definite diagnosis. Despite optimal surveillance interval and recall policies, few non-curative stage diagnoses seemed inevitable under current standard of care

    Time-Domain Multi-modal Bone/air Conducted Speech Enhancement

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    Previous studies have proven that integrating video signals, as a complementary modality, can facilitate improved performance for speech enhancement (SE). However, video clips usually contain large amounts of data and pose a high cost in terms of computational resources and thus may complicate the SE system. As an alternative source, a bone-conducted speech signal has a moderate data size while manifesting speech-phoneme structures, and thus complements its air-conducted counterpart. In this study, we propose a novel multi-modal SE structure in the time domain that leverages bone- and air-conducted signals. In addition, we examine two ensemble-learning-based strategies, early fusion (EF) and late fusion (LF), to integrate the two types of speech signals, and adopt a deep learning-based fully convolutional network to conduct the enhancement. The experiment results on the Mandarin corpus indicate that this newly presented multi-modal (integrating bone- and air-conducted signals) SE structure significantly outperforms the single-source SE counterparts (with a bone- or air-conducted signal only) in various speech evaluation metrics. In addition, the adoption of an LF strategy other than an EF in this novel SE multi-modal structure achieves better results.Comment: multi-modal, bone/air-conducted signals, speech enhancement, fully convolutional networ
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