Uncharitable Treatment? Why Donations to Private and Public Foundations Deserve Equal Tax Status

Canada’s public foundations and charities got a helping hand from Ottawa last year when the May federal budget removed the capital gains tax on listed securities given as donations. While the change facilitated gifts of stock to these public organizations, their philanthropic cousins, private foundations, did not benefit. This differential treatment potentially discourages donations to, and the development of, private foundations.governance and public institutions, charitable sector

Isolation of Low-Abundant Bacteroidales in the Human Intestine and the Analysis of Their Differential Utilization Based on Plant-Derived Polysaccharides

Bacteroidales are the most abundant Gram-negative bacteria flourished in the human intestine with great underlying benefits to be discovered and developed as the next-generation probiotics. However, the traditional isolation method limits the mining of low-abundant species. In this study, modified selective medium was established using xylan as the sole carbohydrate source to enrich low-abundant species such as Prevotella copri and Bacteroides xylanisolvens from healthy human fecal samples. The growth rate, transcriptomics, and metabolomics profiles of the enriched low-abundant species were then evaluated. The considerable upregulated genes encoding xylan-associated hydrolysis and transportation, along with the increased xylose production detected in the culture of the enriched Bacteroidales strains based on xylan, were considered as positive proof of the feasibility of the modified methodology

Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus

Bacteroides ovatus ELH-B2 is considered as a potential next-generation probiotic due to its preventive effects on lipopolysaccharides-associated inflammation and intestinal microbiota disorders in mice. To study safety issues associated with B. ovatus ELH-B2, we conducted comprehensive and systematic experiments, including in vitro genetic assessments of potential virulence and antimicrobial resistance genes, and an in vivo acute toxicity study of both immunocompetent and immunosuppressed mice via cyclophosphamide treatment. The results indicated that this novel strain is non-toxigenic, fragilysin is not expressed, and most of potential virulence genes are correlated with cellular structures such as capsular polysaccharide and polysaccharide utilizations. The antibiotic resistance features are unlikely be transferred to other intestinal microorganisms as no plasmids nor related genomic islands were identified. Side effects were not observed in mice. B. ovatus ELH-B2 also alleviated the damages caused by cyclophosphamide injection

Cumulative live birth rates and birth outcomes after IVF/ICSI treatment cycles in young POSEIDON patients: A real-world study

ObjectiveThe aim of this study was to describe the cumulative live birth rates (CLBRs) of young women with or without low prognosis according to the POSEIDON criteria after IVF/ICSI cycles and to investigate whether the diagnosis of low prognosis increases the risk of abnormal birth outcomes.DesignRetrospective study.SettingA single reproductive medicine center.PopulationFrom January 2016 to October 2020, there were 17,893 patients (<35 years) involved. After screening, 4,105 women were included in POSEIDON group 1, 1,375 women were included in POSEIDON group 3, and 11,876 women were defined as non-POSEIDON.Intervention(s)Baseline serum AMH level was measured on the D2–D3 of menstrual cycle before IVF/ICSI treatment.Main outcome measure(s)Cumulative live birth rate (CLBR), birth outcomes.Result(s)After four stimulation cycles, the CLBRs in POSEIDON group 1, POSEIDON group 3, and non-POSEIDON group reached 67.9% (95% CI, 66.5%–69.3%), 51.9% (95% CI, 49.2%–54.5%), and 79.6% (95% CI, 78.9%–80.3%), respectively. There was no difference in gestational age, preterm delivery, cesarean delivery, and low birth weight infants between the three groups, but macrosomia was significantly higher in non-POSEIDON group, after adjusting for maternal age and BMI.Conclusion(s)The POSEIDON group shows lower CLBRs than the non-POSEIDON group in young women, while the risk of abnormal birth outcomes in the POSEIDON group will not increase

Vortex Generation and Auroral Response to a Solar Wind Dynamic Pressure Increase: Event Analyses

In this study, we investigate ionospheric responses, including currents and aurorae, to solar wind dynamic pressure (SW Pdyn) sudden increases, which are critical for understanding solar wind‐magnetosphere‐ionosphere coupling. We focus on two similar SW Pdyn pulse events that occurred on 24 January 2012 and 12 November 2010. In both cases, equivalent ionospheric currents (EIC) vortices were generated within about ten minutes after the pressure pulse arrival, with a counter‐clockwise rotating vortex (viewed from above) observed on the dusk side in the former case, and a clockwise vortex observed on the dawn side in the latter. Simultaneous ground‐based All‐Sky Imager (ASI) observations in the vicinity of the observed EIC vortex in each case showed that aurorae intensified on the dusk side, and diminished on the dawn side. These observations provide direct evidence of the scenario proposed byShi et al. (2014) that magnetospheric flow vortices generated by a solar wind pressure pulse carry field‐aligned currents into the ionosphere and thereby modulate auroral activity. The dawn/dusk asymmetry in the auroral intensification is a direct result of the opposite sense of vortex rotation on the dawn and dusk sides, which generate oppositely directed field‐aligned currents into/out of the ionosphere

Evidence for lunar tide effects in Earth’s plasmasphere

Tides are universal and affect spatially distributed systems, ranging from planetary to galactic scales. In the Earth–Moon system, effects caused by lunar tides were reported in the Earth’s crust, oceans, neutral gas-dominated atmosphere (including the ionosphere) and near-ground geomagnetic field. However, whether a lunar tide effect exists in the plasma-dominated regions has not been explored yet. Here we show evidence of a lunar tide-induced signal in the plasmasphere, the inner region of the magnetosphere, which is filled with cold plasma. We obtain these results by analysing variations in the plasmasphere’s boundary location over the past four decades from multisatellite observations. The signal possesses distinct diurnal (and monthly) periodicities, which are different from the semidiurnal (and semimonthly) variations dominant in the previously observed lunar tide effects in other regions. These results demonstrate the importance of lunar tidal effects in plasma-dominated regions, influencing understanding of the coupling between the Moon, atmosphere and magnetosphere system through gravity and electromagnetic forces. Furthermore, these findings may have implications for tidal interactions in other two-body celestial systems

Microstructural and functional impairment of the basal ganglia in Wilson’s disease: a multimodal neuroimaging study

ObjectivesMagnetic susceptibility changes in brain MRI of Wilson’s disease (WD) patients have been described in subcortical nuclei especially the basal ganglia. The objectives of this study were to investigate its relationship with other microstructural and functional alterations of the subcortical nuclei and the diagnostic utility of these MRI-related metrics.MethodsA total of 22 WD patients and 20 healthy controls (HCs) underwent 3.0T multimodal MRI scanning. Susceptibility, volume, diffusion microstructural indices and whole-brain functional connectivity of the putamen (PU), globus pallidus (GP), caudate nucleus (CN), and thalamus (TH) were analyzed. Receiver operating curve (ROC) was applied to evaluate the diagnostic value of the imaging data. Correlation analysis was performed to explore the connection between susceptibility change and microstructure and functional impairment of WD and screen for neuroimaging biomarkers of disease severity.ResultsWilson’s disease patients demonstrated increased susceptibility in the PU, GP, and TH, and widespread atrophy and microstructural impairments in the PU, GP, CN, and TH. Functional connectivity decreased within the basal ganglia and increased between the PU and cortex. The ROC model showed higher diagnostic value of isotropic volume fraction (ISOVF, in the neurite orientation dispersion and density imaging model) compared with susceptibility. Severity of neurological symptoms was correlated with volume and ISOVF. Susceptibility was positively correlated with ISOVF in GP.ConclusionMicrostructural impairment of the basal ganglia is related to excessive metal accumulation in WD. Brain atrophy and microstructural impairments are useful neuroimaging biomarkers for the neurological impairment of WD

ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner

Abstract Background Programmed cell death is an important mechanism for the development of hepatic ischemia and reperfusion (IR) injury, and multiple novel forms of programmed cell death are involved in the pathological process of hepatic IR. ERRFI1 is involved in the regulation of cell apoptosis in myocardial IR. However, the function of ERRFI1 in hepatic IR injury and its modulation of programmed cell death remain largely unknown. Methods Here, we performed functional and molecular mechanism studies in hepatocyte-specific knockout mice and ERRFI1-silenced hepatocytes to investigate the significance of ERRFI1 in hepatic IR injury. The histological severity of livers, enzyme activities, hepatocyte apoptosis and ferroptosis were determined. Results ERRFI1 expression increased in liver tissues from mice with IR injury and hepatocytes under oxygen-glucose deprivation/reoxygenation (OGD/R) conditions. Hepatocyte-specific ERRFI1 knockout alleviated IR-induced liver injury in mice by reducing cell apoptosis and ferroptosis. ERRFI1 knockdown reduced apoptotic and ferroptotic hepatocytes induced by OGD/R. Mechanistically, ERRFI1 interacted with GRB2 to maintain its stability by hindering its proteasomal degradation. Overexpression of GRB2 abrogated the effects of ERRFI1 silencing on hepatocyte apoptosis and ferroptosis. Conclusions Our results revealed that the ERRFI1-GRB2 interaction and GRB2 stability are essential for ERRFI1-regulated hepatic IR injury, indicating that inhibition of ERRFI1 or blockade of the ERRFI1-GRB2 interaction may be potential therapeutic strategies in response to hepatic IR injury

How dyadic emotional transmission shapes teacher-student relationship: effects of emotional convergence on cohesion in teacher-student interaction

Understanding the dynamics of teacher-student relationships is crucial, and emotional exchange plays a pivotal role in this process. This study aims to investigate the predictive mechanisms underlying affective and physiological responses synchrony, specifically focusing on positive emotional convergence and its impact on emotional cohesion during teacher-student interactions. To achieve this, we implemented a novel reading-following paradigm to induce teacher-student interaction within an actual classroom setting. Galvanic skin response (GSR) signals were collected using wrist-worn wearable devices from both teachers and students during class. Following each session, teachers and students individually completed questionnaires to evaluate the quality of their interaction and the cohesion between them. Results indicate that the reading-following paradigm facilitated creative emotional convergence between teachers and students. Moreover, a positive association was observed between teacher-student interaction and teacher-student cohesion, mediated by affective responses synchrony and physiological coupling between teachers and students. Additionally, the influence of teacher-student interaction on affective responses synchrony was moderated by physiological predictability. The implications of these findings for future research and their potential application in the classroom setting are discussed.</p

Evaluation of the Accuracy of the Field Quadrat Survey of Alpine Grassland Fractional Vegetation Cover Based on the Satellite Remote Sensing Pixel Scale

The fractional vegetation cover (FVC) data measured on the ground is the main source for the calibration and verification of FVC remote sensing inversion, and its accuracy directly affects the accuracy of remote sensing inversion results. However, the existing research on the evaluation of the accuracy of the field quadrat survey of FVC based on the satellite remote sensing pixel scale is inadequate, especially in the alpine grassland of the Qinghai-Tibet Plateau. In this paper, five different alpine grasslands were examined, the accuracy of the FVC obtained by the photography method was analyzed, and the influence of the number of samples on the field survey results was studied. First, the results show that the threshold method could accurately extract the vegetation information in the photos and obtain the FVC with high accuracy and little subjective interference. Second, the number of samples measured on the ground was logarithmically related to the accuracy of the FVC of the sample plot (p &lt; 0.001). When the number of samples was larger, the accuracy of the FVC of the sample plot was higher and closer to the real value, and the stability of data also increased with the increase of the number of samples. Third, the average FVC of the measured quadrats on the ground was able to represent the FVC of the sample plot, but on the basis that there were enough measured quadrats. Finally, the results revealed that the degree of fragmentation reflecting the state of ground vegetation affects the acquisition accuracy of FVC. When the degree of fragmentation of the sample plot is higher, the number of samples needed to achieve the accuracy index is higher. Our results suggest that when obtaining the FVC on the satellite remote sensing pixel scale, the number of samples measured on the ground is an important factor affecting the accuracy, which cannot be ignored