2 research outputs found
Enhancing Neuroprotection in Mouse Model of Parkinson’s Disease through Protein Nanosystem Conjugation with ApoE Peptide for miR-124 Delivery
Parkinson’s
disease (PD) affects millions of people’s
lives worldwide. The main pathogenesis of PD is dopaminergic neuron
necrosis and neuroinflammation mediated by activated microglia cells.
In recent years, the anti-inflammatory ability and neuroprotective
effects of miR-124 in PD models were well proved, but the in vivo
delivery of miR-124 remains challenging. Herein, we report a protein
nanosystem modified with a brain-targeting peptide ApoE that could
efficiently deliver miR-124 across the blood–brain barrier
(BBB). This nanosystem showed good cell viability on brain endothelial
cells and microglia cells, and administration of this nanosystem significantly
decreased the neuroinflammation and dopaminergic neuron loss, as well
as recovered parts of neurobehavioral deficits. This ApoE peptide-based
protein nanosystem holds great promise for the delivery of RNA therapeutics
to the brain and for realizing neuron protection in PD treatment
Concordance of IHC-HER2 expression between local laboratories and the central laboratory.*
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