3 research outputs found
Control of a Ternary Extractive Distillation Process with Recycle Splitting Using a Mixed Entrainer
Dynamic
control of the ternary extractive distillation process
is complex, due to the relatively high number of operating parameters
and interactions between multiple azeotropes. In this research, the
control structures of the ternary extractive distillation using dimethyl
sulfoxide and a mixed solvent of dimethyl sulfoxide and ethylene glycol,
as the entrainer, were explored for separating tetrahydrofuran/ethanol/water.
A composition with a ratio of reboiler duty to mole feed flow rate
control structure was proposed to obtain good dynamic responses for
the ternary extractive distillation process with dimethyl sulfoxide
and mixed entrainer. Moreover, control comparisons of the ternary
extractive distillation with dimethyl sulfoxide and mixed entrainer
demonstrated that the dynamic performances of the extractive distillation
with mixed entrainer were better compared with the process using dimethyl
sulfoxide. These studies contribute to the development of controllability
for ternary extractive distillation processes for separating ternary
or multicomponent azeotropic mixtures
Polymethoxyflavone–Enriched Fraction from Ougan (Citrus reticulata cv. Suavissima) Attenuated Diabetes and Modulated Gut Microbiota in Diabetic KK‑A<sup>y</sup> Mice
Diabetes mellitus is a serious, chronic disease worldwide;
yet
it is largely preventable through physical activity and healthy diets.
Ougan (Citrus reticulata cv. Suavissima) is a characteristic citrus variety rich
in polymethoxyflavones. In the present study, the anti-diabetic effects
of the polymethoxyflavone-enriched fraction from Ougan (OG-PMFs) were
investigated. Diabetic KK-Ay mice were supplemented with
different doses of OG-PMFs for 5 weeks. Our results demonstrated that
OG-PMFs exhibited robust protective effects against diabetes symptoms
in KK-Ay mice. The potential mechanisms may partially be
attributed to the restoration of hepatic GLUT2 and catalase expression.
Notably, OG-PMF administration significantly altered the gut microbiota
composition in diabetic KK-Ay, indicated by the suppression
of metabolic disease-associated genera Desulfovibrio, Lachnoclostridium, Enterorhabdus, and Ralstonia, implying that the gut microbiota might be another target for OG-PMFs
to show effects. Taken together, our results provided a supplementation
for the metabolic-protective effects of PMFs and highlighted that
OG-PMFs hold great potential to be developed as a functional food
ingredient
Surface density of polyarginine influence the size, zeta potential, cellular uptake and tissue distribution of the nanostructured lipid carrier
<p>Poly-arginines are strong tools to elevate the cellular uptake of nanopreparations. To learn the influence of poly-arginine (RRRRRRRR, R8) density on a series of properties of nanostructured lipid carrier (NLC), we build six R8 modified NLCs with different R8 densities (nR-NLC, where n represents the R8 ratio) by fusion–emulsion method with the aid of stearyl-R8. The pharmaceutical characteristics like size, zeta potential and <i>in vitro</i> drug release, cellular uptake, cytotoxicity to A549 cells and tissue distribution in S180 tumor-bearing mice of the six nR-NLCs are all investigated. It turns out that with as little as 2% weight ratio of stearyl-R8 modified on NLC, its pharmaceutical properties, especially zeta potential changes astonishingly; however, the stearyl-R8 ratio should be higher than 4% to upgrade the cellular uptake and cytotoxicity evidently; in the <i>ex vivo</i> tissue distribution assessment, the nR-NLC with less than 8% R8 showed similar tissue accumulation, while NLC with 10% R8 shows obvious acute toxicity to mice. Our study pays attention to the effect of the R8 ratio on the changes of cargo properties, and the results indicate that this topic is essential and worth to be further developed.</p