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    Additional file 1: Figure S1. of Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice

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    The effect of sinomenine on cell viability and inflammation response in astrocytes. Figure S2. Astrocytes were more hyper-responsive in sinomenine suppressing OGD-induced inflammation than microglia. Figure S3. Sinomenine increased nuclear expression of CRYAB in astrocytes. Figure S4. Blood-brain barrier (BBB) disruption evaluation by Evans blue (EB) extravasation in sham and MCAO mice. Figure S5. Effect of sinomenine on the number and activation of astrocytes after MCAO. Figure S6. Immunological identification of primary astrocyte culture. Figure S7. Effect of sinomenine on the number and activation of microglia after MCAO. Flow cytometry. (DOCX 0.99 MB
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