Study of dynamic plastic buckling of cylindrical shell impacted by sudden constant load

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The Impact Of The Knowledge Sharing In Social Media On Consumer Behaviour

In the recent years, there is a significant rise in the usage of social networking site for organizations to organize marketing campaigns. It is necessary for advertisers to structure their information well in order for consumers to accept the message or product information. This study investigated the consumer purchasing process and knowledge flows between individuals in social media, at the same time considering the different type of proximity that affect it. Using the consumer purchasing decision process[1] as a source of credibility, this study will analyze from several research paper to test its hypothesis related to the different types of proximity. Results and theories have shown that advertisement and product information in social media are affected by the different types of proximity plays, which is creating an impact in the consumer purchasing decision process

Translating XPS Measurement Procedure for Band Alignment into Reliable Ab-initio Calculation Method

Band alignment between solids is a crucial issue in condensed matter physics and electronic devices. Although the XPS method has been used as a routine method for determination of the band alignment, the theoretical calculations by copying the XPS band alignment procedure usually fail to match the measured results. In this work, a reliable ab-initio calculation method for band alignment is proposed on the basis of the XPS procedure and in consideration of surface polarity and lattice deformation. Application of our method to anatase and rutile TiO2 shows well agreement between calculation and experiment. Furthermore, our method can produce two types of band alignment: the coupled and the intrinsic, depending on whether the solid/solid interface effect is involved or not. The coupled and intrinsic band alignments correspond to alignments measured by XPS and electrochemical impedance analysis, respectively, explaining why band alignments reported by these two experiments are rather inconsistent

Modeling and optimal design for the fixed plate of steel ball grinding machine

A three-dimensional model of the fixed plate of steel ball grinding machines is established using finite element methods. Its distortion and stress status are analyzed, and the natural frequencies and vibration features are obtained. By using the circular area of elastic contacts, the number of effective cutting edges is determined, and a mathematical model is established between the grinding pressure and depth. Then the structural optimization design is programmed with the APDL language of ANSYS. Under its strength being considered, the accurate and reliable design parameters of structures are obtained. Simulation results show that the machining accuracy of steel balls is improved

Clinical Observation of Erlotinib in the Treatment of Advanced Non-small Cell Lung Cancer: A Report of 92 Eases

Background and objective Erlotinib, a selective inhibitor of epidermal growth factor receptor tyrosine kinase, has been approved effective in local advanced or metastatic non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the efficacy and safety of erlotinib for the treatment of advanced NSCLC. Methods Ninety-two patients with advanced NSCLC who had failed or not tolerated or refused chemotherapy received 150 mg oral doses of erlotinib once daily until the disease progression or intolerable toxicity. Results Among the 92 NSCLC patients, 2 patient got complete response (2.2%), 22 partial response (23.9%), 48 stable disease (52.2%) and 20 progressive disease (21.7%). The overall response rate and the disease controlled rate of erlotinib was 26.1% (24/92) and 78.3% (72/92), respectively. The response rate of erlotinib were significantly higher in rash and ECOG 0-1 than no rash and ECOG ≥ 2. The disease controlled rate of erlotinib was significantly higher in female and non-smokers than male and smokers (P < 0.05). The response rate of erlotinib did not show significant differences within pathological type or previous treatment. The most common side effects were rash and diarrhea with 84.8% and 31.5%, respectively, but usually were mild. Conclusion Erlotinib is effective and safe in the treatment of advanced NSCLC patients

Bis(6′-carb­oxy-2,2′-bipyridine-6-carboxyl­ato-κ3 N,N′,O 6)nickel(II) tetra­hydrate

In the title compound, [Ni(C12H7N2O4)2]·4H2O, the Ni atom is located at the centre of a distorted octa­hedron, formed by four N atoms and two O atoms from the same two tridentating chelated 6-carb­oxy-2,2′-bipyridine-6′-carboxyl­ate (L) ligands. Face-to-face π-stacking inter­actions between inversion-related pyridine rings with centroid–centroid distances of 3.548 (3) and 3.662 (3) Å (perpendicular distances between the respective rings are 3.314 and 3.438 Å) are found. Inter­molecular O—H⋯O hydrogen bonds between water mol­ecules and L ligands form R 5 3(10), R 6 5(14) and R 5 5(12) rings and also a centrosymmetric cage-like unit of water mol­ecules, which link eight adjacent NiII centers, forming a three-dimensional framework

Long non-coding RNA H19 correlates with unfavorable prognosis and promotes cell migration and invasion in ovarian cancer

The purpose of this study is to investigate the expression pattern of lncRNA H19 in OC tissues and to detect the ability of H19 to influence OC cell migration and invasion in vitro. We quantified the levels of H19 within the obtained cancerous and adjacent noncancerous tissues from 258 OC patients. H19 association with patient progression-free survival (PFS) was analyzed by a Kaplan-Meier plot. Expression levels of H19 were reduced by small interfering RNA transfection against H19 or restored by a H19 overexpression plasmid transfection in OC cells. H19 effects on OC cell migration and invasion in vitro were evaluated using wound-healing assay and transwell invasion assay. Wound healing assay and transwell invasion assay were used to evaluate the effects of H19 on OC cell migration and invasion in vitro. H19 is upregulated remarkably in primary OC tissues and human OC cell lines (OVCAR3, SKOV3, A2780, and Caov-3). We found that the median PFS was longer in patients with lower levels of H19 than in those with high levels, suggesting that overexpression of H19 was linked to poor prognosis in OC patients. Intriguingly, the depletion of H19 expression induced by small interfering RNA inhibited the capability of migration and invasion of OC cell lines. Restoration of H19 in OC cell lines significantly increased cell migration and invasion. The key finding of the present study suggests that overexpression of H19 may be associated with an unfavorable prognosis for OC and is likely to be a possible contributory force involved in OC cell migration and invasion. H19 may provide a new and attractive target for future prognostic and therapeutic intervention of OC patients