Patients\u27 Acceptance of Smartphone Health Technology for Chronic Disease Management: A Theoretical Model and Empirical Test

Les quatre textes ont en commun de présenter certaines évolutions récentes de l’histoire politique en Allemagne. Ils prennent tous position face à trois tournants historiographiques. La notion d’histoire culturelle du politique peut servir d’emblème au premier de ces tournants : le politique est envisagé non plus comme une succession d’événements ni comme le fruit de déterminations structurelles dont il serait la superstructure ou l’écume, mais comme l’expression de valeurs et de procédures o..

Space advanced technology demonstration satellite

The Space Advanced Technology demonstration satellite (SATech-01), a mission for low-cost space science and new technology experiments, organized by Chinese Academy of Sciences (CAS), was successfully launched into a Sun-synchronous orbit at an altitude of similar to 500 km on July 27, 2022, from the Jiuquan Satellite Launch Centre. Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit, SATech-01 is equipped with 16 experimental payloads, including the solar upper transition region imager (SUTRI), the lobster eye imager for astronomy (LEIA), the high energy burst searcher (HEBS), and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer (CPT). It also incorporates an imager with freeform optics, an integrated thermal imaging sensor, and a multi-functional integrated imager, etc. This paper provides an overview of SATech-01, including a technical description of the satellite and its scientific payloads, along with their on-orbit performance

crcTRP: A Translational Research Platform for Colorectal Cancer

Colorectal cancer is a leading cause of cancer mortality in both developed and developing countries. Transforming basic research results into clinical practice is one of the key tasks of translational research, which will greatly improve the diagnosis and treatments of colorectal cancer. In this paper, a translational research platform for colorectal cancer, named crcTRP, is introduced. crcTRP serves the colorectal cancer translational research by providing various types of biomedical information related with colorectal cancer to the community. The information, including clinical data, epidemiology data, individual omics data, and public omics data, was collected through a multisource biomedical information collection solution and then integrated in a clinic-omics database, which was constructed with EAV-ER model for flexibility and efficiency. A preliminary exploration of conducting translational research on crcTRP was implemented and worked out a set of clinic-genomic relations, linking clinical data with genomic data. These relations have also been applied to crcTRP to make it more conductive for cancer translational research

Polymorphism of keratin 1 associates with systemic lupus erythematosus and systemic sclerosis in a south Chinese population.

Both systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) diseases are related to the genetic and environmental factors, causing damage to the skin. The mutations of keratin 1 gene (KRT1) were reported to associate with skin diseases. The single-nucleotide polymorphism (SNP, rs14024) and the indel polymorphism (cds-indel, rs267607656), consisting mostly of the common haplotypes and could be used for genotyping of KRT1. We used the PCR with sequence specific primers (PCR-SSP) to determine the genotype of KRT1 in 164 SLE, 99 SSc patients, and 418 healthy controls. The results showed that the mutant with G at SNP rs14024 was associated with the high risk to SLE (p = 6.48×10-5) and SSc (p = 8.75×10-5), while the deletion allele at rs267607656 was associated with the low risk to SSc (p = 4.89×10-4) comparing to the normal controls. Haplogenotype, Del-/MU+ was associated with high susceptibility to SLE (OR = 1.87, p = 0.001) and SSc (OR = 2.29, p = 2.34×10-4). In contrast, the Haplogenotype Del+/MU- was associated with resistance to SLE (OR = 0.35, p = 6.24×10-5) and SSc (OR = 0.34, p = 0.001). This study demonstrates that the variations in KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc. Typing KRT1 might be helpful to identify SLE and SSc patients

Method to Remove Tilt-to-Length Coupling Caused by Interference of Flat-Top Beam and Gaussian Beam

We discuss the tilt-to-length (TTL) coupling noise caused by interference between a flat-top beam and a Gaussian beam. Several physical models are presented to research the effects of non-diffracted and diffracted beams on TTL noise. A special case that can remove TTL coupling noise is discovered and is verified via both theoretical analysis and numerical simulations. The proposed case could provide desirable suggestions for the construction of high-precision interferometers such as the Laser Interferometer Space Antenna (LISA), Taiji program, or other interferometry systems

Clinic-Genomic Association Mining for Colorectal Cancer Using Publicly Available Datasets

In recent years, a growing number of researchers began to focus on how to establish associations between clinical and genomic data. However, up to now, there is lack of research mining clinic-genomic associations by comprehensively analysing available gene expression data for a single disease. Colorectal cancer is one of the malignant tumours. A number of genetic syndromes have been proven to be associated with colorectal cancer. This paper presents our research on mining clinic-genomic associations for colorectal cancer under biomedical big data environment. The proposed method is engineered with multiple technologies, including extracting clinical concepts using the unified medical language system (UMLS), extracting genes through the literature mining, and mining clinic-genomic associations through statistical analysis. We applied this method to datasets extracted from both gene expression omnibus (GEO) and genetic association database (GAD). A total of 23517 clinic-genomic associations between 139 clinical concepts and 7914 genes were obtained, of which 3474 associations between 31 clinical concepts and 1689 genes were identified as highly reliable ones. Evaluation and interpretation were performed using UMLS, KEGG, and Gephi, and potential new discoveries were explored. The proposed method is effective in mining valuable knowledge from available biomedical big data and achieves a good performance in bridging clinical data with genomic data for colorectal cancer

Durable drag reduction and anti-corrosion for liquid flows inside lubricant-infused aluminum/copper capillaries

Frictional drag reduction and anti-corrosion for the liquid flows in micro- and nanochannels result in considerable economic and environmental benefits. The lubricant infused surface (LIS) has emerged as a promising technology for achieving the two functionalities. This work proposes the fabrication of LISs on the inner walls of metal capillaries for endowing the capillaries with sustainable drag reduction and anti-corrosion properties. Specifically, we demonstrate the fabrication of the LIS aluminum (Al) capillaries with varying viscosity of lubricants and systematically investigate their drag reduction performance by measuring the relationship between the frictional factor/slip length and Reynolds number. We find that the LIS Al capillary exhibits durable drag reduction and anti-corrosion characteristics which can also be achievable in other LIS metal capillaries, such as LIS copper capillaries. A comparison of the LIS Al capillary with the Al capillary with a superhydrophobic surface (SHS) suggests that the former outperforms the latter in terms of durability, e.g., the LIS capillary with the lowest lubricant viscosity considered can withstand a shear force as high as Re≈700, which is more than twice that of the SHS capillary (Re≈300). The LIS capillaries can reduce the frictional factor by up to 30%. Varying the viscosity of infusion lubricants is an effective way to tune the drag reduction performance of the LIS metal capillaries. The present work paves a way for applying LIS metal capillaries in instrumentation, thermal management, microfluidic devices, etc.We acknowledge the financial support received from the National Natural Science Foundation of China (No. 51976157, No. 51721004), Xi’an Science and Technology Bureau (No.2020KJRC0057), the Fundamental Research Fund for the Central Universities (No. xzy012020075) and the Open Fund of MOE Key Laboratory for Thermal Science and Power Engineering in 2021

The allele frequencies of SNP rs14024 and indel rs267607656 in different populations.

<p>The allele frequencies of SNP rs14024 and indel rs267607656 in different populations.</p

Mechanical Stubble Righting after the Mechanical Harvest of Primary Rice Improves the Grain Yield of Ratooning Rice

Ratooning rice is an essential rice-planting method. However, mechanical harvesting of the primary rice crop, while increasing efficiency, can negatively affect the yield of ratooning rice. Therefore, it is crucial to find ways to improve the grain yield of ratooning rice after the mechanical harvest of the primary rice. A two-year field experiment was conducted; the grain yield of ratooning rice was assessed by stubble righting after mechanical harvesting of primary rice. The study used two popular rice cultivars, YLiangyou911 and Kenliangyou801, as experimental materials. The experimental treatments included three groups: one without righting after rolling rice stubble (CK), another with mechanized righting after rolling rice stubble (T1), and a third one without rolling rice stubble by the machine (T2). The results of the study demonstrate that stubble righting after the mechanical harvest of primary rice (T1) had a substantial impact on the grain yield of ratooning rice. It led to grain yields similar to ratooning rice without mechanical rolling of the rice stubble (T2) and significantly outperformed the treatment without stubble righting after the mechanical harvest of primary rice (CK). The study observed significant effects of the year of the experiment (Y), the treatment applied (T), and the interaction between year and treatment (Y×T) on grain yield. Additionally, the treatment showed a significant influence on the yield components. Specifically, in 2021, the T1 and T2 treatments showed remarkable grain yield increases in YLiangyou911 by 107.41% and 147.97%, respectively, compared to CK. For Kenliangyou801 in 2021, the T1 and T2 treatments also resulted in notable improvements in grain yield by 45.85% and 114.26%, respectively. Similarly, in 2022, the grain yield increased by 6.99% for T1 and 23.87% for T2 in YLiangyou911, and by 77.23% for T1 and 187.13% for T2 in Kenliangyou801, compared to CK. The study also detected enhancements in several aspects, including biomass accumulation, solar radiation and photosynthetic characteristics, antioxidant response and nitrogen metabolism, and bud-regeneration capacity due to T1 and T2 treatments. Furthermore, correlation analysis was conducted to assess the relationship between grain yield and the investigated parameters. In conclusion, stubble righting after the mechanical harvest of primary rice resulted in significantly improved grain yield for ratooning rice. This improvement can be attributed to enhanced biomass accumulation, solar radiation and photosynthetic characteristics, antioxidant response and nitrogen metabolism, and increased bud-regeneration capacity