1 research outputs found
Cu<sub>2–<i>x</i></sub>S Nanocrystals Cross-Linked with Chlorin e6-Functionalized Polyethylenimine for Synergistic Photodynamic and Photothermal Therapy of Cancer
Achieving
an integrated system for combinational therapy of cancer
with enhanced efficacy is always a challenge. A multifunctional system
(CCeT nanoparticles (NPs)) for a synergistic photodynamic and photothermal
cancer therapy was successfully developed. This system is composed
of Cu<sub>2–<i>x</i></sub>S nanoclusters functionalized
with chlorin e6 (Ce6)-conjugated branched polyethylenimine (PEI-Ce6)
and mitochondria-targeting 3-(carboxypropyl)Âtriphenylphosphonium bromide
(TPP-COOH). The colocalization of the resulted CCeT NPs inside the
mitochondria of cancer cells was proven. The CCeT NPs exhibited significant
photodynamic therapy (PDT) efficacy due to efficient singlet oxygen
(<sup>1</sup>O<sub>2</sub>) generation triggered by a 630 nm laser.
This system also showed excellent photothermal conversion capability
upon the irradiation of 808 nm laser for photothermal therapy (PTT).
In particular, the platform achieved nearly 100% inhibitory rate of
the tumor growth in vivo through combinational PDT and PTT. Thus,
the CCeT NPs could efficiently inhibit the tumor growth in vitro and
in vivo by combinational PDT and PTT, offering synergistic therapeutic
efficiency as compared to PTT or PDT alone