3 research outputs found
A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy
Multifunctional synergistic
therapy holds promise in biomedical
studies and clinical practice. However, strategies aimed at easily
integrating the components of such multimodal therapies are needed.
Therefore, we herein report a smart drug release nanosystem able to
perform photodynamic therapy, photothermal therapy and chemotherapy
in a photocontrollable manner. Doxorubicin (DOX), a chemotherapy drug,
and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP4),
a photosensitizer, were physically intercalated into a DNA assembly
immobilized on gold nanorods. The drugs were efficiently delivered
to target cells and released under light irradiation, resulting in
a synergism that combined phototherapy and chemotherapy for cancer
treatment. This smart, photocontrollable drug release nanosystem promises
precisely controlled drug release for multifunctional synergistic
cancer therapy
One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (−)-Nephrosteranic Acid
Multisubstituted
chiral butyrolactonimidates have been synthesized
via a one-pot, three-step cascade reaction in which (<i>R</i>)-<i>N</i>-<i>tert</i>-butanesulfinyl imidates
and α,β-unsaturated diesters undergo highly stereoselective
Michael addition, anion-oxidative hydroxylation, and cyclization.
The synthesized butyrolactonimidates are versatile intermediates for
preparation of substituted butyrolactones and furans. The usefulness
of this cascade reaction is demonstrated through the concise total
synthesis of natural product (−)-nephrosteranic acid
One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (−)-Nephrosteranic Acid
Multisubstituted
chiral butyrolactonimidates have been synthesized
via a one-pot, three-step cascade reaction in which (<i>R</i>)-<i>N</i>-<i>tert</i>-butanesulfinyl imidates
and α,β-unsaturated diesters undergo highly stereoselective
Michael addition, anion-oxidative hydroxylation, and cyclization.
The synthesized butyrolactonimidates are versatile intermediates for
preparation of substituted butyrolactones and furans. The usefulness
of this cascade reaction is demonstrated through the concise total
synthesis of natural product (−)-nephrosteranic acid