Monitoring international migration flows in Europe. Towards a statistical data base combining data from different sources

The paper reviews techniques developed in demography, geography and statistics that are useful for bridging the gap between available data on international migration flows and the information required for policy making and research. The basic idea of the paper is as follows: to establish a coherent and consistent data base that contains sufficiently detailed, up-to-date and accurate information, data from several sources should be combined. That raises issues of definition and measurement, and of how to combine data from different origins properly. The issues may be tackled more easily if the statistics that are being compiled are viewed as different outcomes or manifestations of underlying stochastic processes governing migration. The link between the processes and their outcomes is described by models, the parameters of which must be estimated from the available data. That may be done within the context of socio-demographic accounting. The paper discusses the experience of the U.S. Bureau of the Census in combining migration data from several sources. It also summarizes the many efforts in Europe to establish a coherent and consistent data base on international migration. The paper was written at IIASA. It is part of the Migration Estimation Study, which is a collaborative IIASA-University of Groningen project, funded by the Netherlands Organization for Scientific Research (NWO). The project aims at developing techniques to obtain improved estimates of international migration flows by country of origin and country of destination

Data School Diary - Day 09 - Data Steward Panel

Audio diary: Data Steward Mini-Panel of CODATA-RDA Research Data Science School 2019 held at the Abdus Salam International Centre for Theoretical Physics in Grignano, near Trieste in Italy between August 5 and August 16. Discussants include members of the data steward stream: Frans Huigen, Data Archiving and Networked Services (DANS)Sanjin Muftic, Digital Scholarship Specialist, University of Cape Town LibrariesCristiana Pisoni, Repository Manager, Universita Degli Studi Di BergamoSothearath Seang, Policy Officer and future Open Science Ambassador, EurodocOrganized by Andjani Gatzweiler. TOC:Introductions0:00.000What is a Data Steward?2:35.479What do you take away?7:26.440Impressions and Suggestions13:16.781Most Memorable17:24.837 Refers to events of 2019-08-15. Recorded with Tascam DR-05 on 2019-08-15 at Adriatico Guest House. Processed with Adobe Audition.</div

D8.5: EOSC Stakeholder Engagement Report

This document reports on the engagement activities undertaken in the EOSCpilot project and highlights good examples of engagement per stakeholder category. Intentional overlaps exist in certain categories, because a need for interconnection and active dialogue between stakeholder categories was identified early on as a significant issue for successful engagement. This report details the outcomes of the engagement activities throughout the project, following the structure of D8.2 Stakeholder Identification & Engagement Strategy Plan. It provides best practices of engagement by Stakeholder Group, as initially identified and mapped in the first period of the project. The report concludes with a set of recommendations for engagement of the EOSC stakeholder groups after the end of the EOSCpilot project

CoreTrustSeal plus FAIR Overview

This document represents the third alignment of CoreTrustSeal to FAIR requirements to inform repositories seeking to enable FAIR data. Further context is presented in the FAIRsFAIR project milestone: https://doi.org/10.5281/zenodo.4003598

M4.2 Draft Maturity Model Based on Extensions and-or Additions to CoreTrustSeal Requirements

Aligning the CoreTrustSeal Requirements with an assessment of repositories' ability to enable FAIR data is an important part of delivering an EOSC. Trustworthy Digital Repositories (TDR) which enable FAIR data are a dependency for many components of modern, open, distributed research. This paper sets the work within the wider context of data infrastructures, describes the co-dependencies between (meta) data objects and their repository environment, and presents the developing mapping between requirements and principles. The evolving capability/maturity approach is explained and the design of a governed assessment and certification process is defined. This work will iterate alongside the wide range of ongoing data infrastructure initiatives to support a range of stakeholders on their journey towards trustworthy repository services that enable FAIR data. Extensive engagement and feedback are planned to allow us to reach this goal

Effect of drugs on renal development

Contains fulltext : 91750.pdf (publisher's version ) (Closed access

Organic anion transporter 1 and 3 influence cellular energy metabolism in renal proximal tubule cells

Organic anion transporter (OAT) 1 and 3 are, besides uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are largely unknown. Hence, we used human conditionally immortalized proximal tubule epithelial cells (ciPTEC) overexpressing OAT1 or OAT3 to gain insight into these mechanisms. In ciPTEC-OAT1 and -OAT3, extracellular lactate levels were decreased (by 77% and 71%, respectively), while intracellular ATP levels remained unchanged, suggesting a shift towards an oxidative phenotype upon OAT1 or OAT3 overexpression. This was confirmed by increased respiration of ciPTEC-OAT1 and -OAT3 (1.4-fold), a decreased sensitivity to respiratory inhibition, and characterized by a higher demand on mitochondrial oxidative capacity. In-depth profiling of tricarboxylic acid (TCA) cycle metabolites revealed reduced levels of intermediates converging into α-ketoglutarate in ciPTEC-OAT1 and -OAT3, which via 2-hydroxyglutarate metabolism explains the increased respiration. These interactions with TCA cycle metabolites were in agreement with metabolomic network modeling studies published earlier. Further studies using OAT or oxidative phosphorylation (OXPHOS) inhibitors confirmed our idea that OATs are responsible for increased use and synthesis of α-ketoglutarate. In conclusion, our results indicate an increased α-ketoglutarate efflux by OAT1 and OAT3, resulting in a metabolic shift towards an oxidative phenotype

Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells

Organic anion transporter (OAT) 1 and 3 are, besides uptake transporters, key in several cellular metabolic pathways. The underlying mechanisms are largely unknown. Hence, we used human conditionally immortalized proximal tubule epithelial cells (ciPTEC) overexpressing OAT1 or OAT3 to gain insight into these mechanisms. In ciPTEC-OAT1 and -OAT3, extracellular lactate levels were decreased (by 77% and 71%, respectively), while intracellular ATP levels remained unchanged, suggesting a shift towards an oxidative phenotype upon OAT1 or OAT3 overexpression. This was confirmed by increased respiration of ciPTEC-OAT1 and -OAT3 (1.4-fold), a decreased sensitivity to respiratory inhibition, and characterized by a higher demand on mitochondrial oxidative capacity. In-depth profiling of tricarboxylic acid (TCA) cycle metabolites revealed reduced levels of intermediates converging into α-ketoglutarate in ciPTEC-OAT1 and -OAT3, which via 2-hydroxyglutarate metabolism explains the increased respiration. These interactions with TCA cycle metabolites were in agreement with metabolomic network modeling studies published earlier. Further studies using OAT or oxidative phosphorylation (OXPHOS) inhibitors confirmed our idea that OATs are responsible for increased use and synthesis of α-ketoglutarate. In conclusion, our results indicate an increased α-ketoglutarate efflux by OAT1 and OAT3, resulting in a metabolic shift towards an oxidative phenotype