In Depth Analysis on the Unusual Multistep Aggregation Process of Oligo(ethylene glycol) Methacrylate-Based Polymers in Water

Dynamic thermal phase transition behavior of a thermoresponsive copolymer P­(MEO₂MA-<i>co</i>-PEGMA₂₀₈₀) synthesized by ATRP random copolymerization of 2-(2-methoxyethoxy)­ethyl methacrylate­(MEO₂MA, <i>M</i>_n = 188 g/mol) and poly­(ethylene glycol) methyl ether methacrylate (PEGMA, <i>M</i>_n= 2080 g/mol) in D₂O was studied by means of infrared spectroscopy in combination with two-dimensional correlation analysis (2Dcos). Because of the absence of strong intermolecular hydrogen bonding interactions between polymer chains and the amphiphilic property of PEGMA₂₀₈₀ with long ethylene glycol segments, this copolymer exhibited an unusual thermally induced multistep aggregation process. In general, the change of hydrophilic side chain takes place before carbonyl groups and backbones during the whole process and thus the driving force of this phase transition process of P­(MEO₂MA-<i>co</i>-PEGMA₂₀₈₀) should be hydration changes of side chains. 2Dcos was finally employed to discern the sequence order of all the group motions during heating process in different temperature regions. It is concluded that during the phase transition P­(MEO₂MA-<i>co</i>-PEGMA₂₀₈₀) chains successively experience “unimers–clusters–micelles– aggregates” four consecutive conformation changes

Complete chloroplast genome of <i>Artabotrys hexapetalus</i> (L.f.) Bhandari 1965 (Annonaceae)

Artabotrys hexapetalus (L.f.) Bhandari, 1965, an evergreen climbing shrub of significant value, is prominent in Chinese history and culture. The whole-gene sequencing of its chloroplast genome using Illumina pair-end sequencing data is conducted during this research. The complete chloroplast genome was determined to be 178,457 bp in size, separated by a large single copy (LSC) and a small single copy (SSC) region of 90,803 and 3,066 bp, respectively. A total of 134 genes were identified, including 90 protein-coding genes, 36 tRNA, and eight rRNA genes. Phylogenetic analysis revealed a close relationship between A. hexapetalus and Artabotrys pilosus, forming a sister branch with 100% support. The study suggests that the chloroplast genome of A. hexapetalus provides valuable insights into its evolutionary history and will contribute to the conservation efforts of this species.</p

Supplemental Material - Validating the Chinese Version of the Academic Grit Scale in Selected Adolescents

Supplemental Material for Validating the Chinese Version of the Academic Grit Scale in Selected Adolescents by Hui Tang, Shujing Zhou, Xiaoqing Du, Qiyun Mo, and Qiang Xing in Journal of Psychoeducational Assessment</p

Meta-analysis of the association between <i>IL-1B +3954</i> polymorphism and CHD risk (T vs. C).

<p>Meta-analysis of the association between <i>IL-1B +3954</i> polymorphism and CHD risk (T vs. C).</p

Summary ORs and 95%CIs of the association between <i>IL-1RN VNTR</i> polymorphism and CHD risk.

<p><i>Notes</i> OR, odds ratio; CI, confidence interval; <i>P</i>_H,<i>P</i> value based on Q test for between-study heterogeneity; HWE =  Hardy–Weinberg equilibrium;</p><p>CHD = coronary artery disease; ACS = acute coronary syndrome; MI = myocardial infarction; PB, Population-based; HB, Hospital-based.</p

Summary ORs and 95%CIs of the association between <i>IL-1B +3954</i> polymorphism and CHD risk.

<p><i>Notes</i> OR, odds ratio; CI, confidence interval; <i>P</i>_H,<i>P</i> value based on Q test for between-study heterogeneity; HWE =  Hardy–Weinberg equilibrium;</p><p>CHD = coronary artery disease; ACS = acute coronary syndrome; MI = myocardial infarction; PB, Population-based; HB, Hospital-based.</p

Synthesis of the chiral intermediate of batzelladines A and B

<p></p> <p>The title compound (<i>S, Z</i>)-methyl 2-[3-(tert-butyldimethylsilyloxy)pyrrolidin-2-ylidene]acetate(<b>6</b>) has been stereoselectively synthesized by the Reformatsky coupling reaction, and the absolute configuration of <b>6</b> was determined by¹H NMRand single-crystal X-ray diffraction.</p

Selection of articles for inclusion in meta-analysis.

<p>Selection of articles for inclusion in meta-analysis.</p

Characteristics of studies included in the meta-analysis.

<p><i>Notes</i> For <i>IL-1B-511</i> and <i>IL-1B+3954</i> polymorphisms, 11 = CC, 12 = CT, 22 = TT; for <i>IL-1RN VNTR</i> polymorphism, 11 = L/L, 12 = *2/L, 22 = *2/*2;</p><p>PB, Population-based; HB, Hospital-based; NA, not available;</p>a<p>, <i>p</i> value for Hardy-Weinberg equilibrium in controls; ^b, allele represented by 1; ^c, allele represented by 2;</p><p>CHD = coronary artery disease; ACS = acute coronary syndrome; MI = myocardial infarction.</p

DataSheet_1_Anti-PD-1 antibodies, a novel treatment option for advanced chemoresistant pulmonary lymphoepithelioma carcinoma.docx

BackgroundPulmonary lymphoepithelioma-like carcinoma (LELC) exhibits a unique immune microenvironment, including high PD-L1 expression and abundant infiltrating-immune cells. However, the availability of PD-1/PD-L1 inhibitors in patients with LELC is still not determined.MethodsA total of 36 cases of pulmonary LELC treated with PD-1/PD-L1 inhibitors were reviewed, including 10 cases from our institute and 26 cases included from the literature. The Kaplan-Meier method and log-rank test were utilized to analyze the survival outcomes of LELC patients receiving immunotherapy, and the factors related to immunotherapy response were further examined.ResultsOf the 10 patients from our institute, the median age was 53.5 years, adrenal glands and distant lymph nodes were the most common metastatic sites, and 4 of 8 (50%) patients had a PD-L1 TPS ≥50%. The median progression-free survival and overall survival in patients from our institute and from the literature were 11.6 and 27.3 months, 17.2 months and not reached, respectively. In all 36 patients, the objective response rate was as high as 57.6%. Patients with higher PD-L1 expression were more likely to have a tumor response, but the association of PD-L1 expression with survival time remains to be determined.ConclusionsPD-1/PD-L1 inhibitors in patients with pulmonary LELC demonstrated a promising efficacy in retrospective cohorts, and deserve further validation in prospective studies administrating in front-line setting.</p