5 research outputs found
14th Annual Conference on Legal Issues For Financial Institutions
Materials from the 14th Annual Conference on Legal Issues For Financial Institutions held by UK/CLE in March 1994
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On the nature of the frontal zone of the Choctawhatchee Bay plume in the Gulf of Mexico
River plumes often feature turbulent processes in the frontal zone and interfacial region at base of the plume, which ultimately impact spreading and mixing rates with the ambient coastal ocean. The degree to which these processes govern overall plume mixing is yet to be quantified with microstructure observations. A field campaign was conducted in a river plume in the northeast Gulf of Mexico in December 2013, in order to assess mixing processes that could potentially impact transport and dispersion of surface material near coastal regions. Current velocity, density, and Turbulent Kinetic Energy Values, ε, were obtained using an Acoustic Doppler Current Profiler (ADCP), a Conductivity Temperature Depth (CTD) profiler, a Vertical Microstructure Profiler (VMP), and two Acoustic Doppler Velocimeters (ADVs). The frontal region contained ε values on the order of 10−5 m2 s−3, which were markedly larger than in the ambient water beneath (O 10−9 m2 s−3). An energetic wake of moderate ε values (O 10−6 m2 s−3) was observed trailing the frontal edge. The interfacial region of an interior section of the plume featured opposing horizontal velocities and a ε value on the order of 10−6 m2 s−3. A simplified mixing budget was used under significant assumptions to compare contributions from wind, tides, and frontal regions of the plume. The results from this order of magnitude analysis indicated that frontal processes (59%) dominated in overall mixing. This emphasizes the importance of adequate parameterization of river plume frontal processes in coastal predictive models
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APOE ε4 and Alzheimer's disease diagnosis associated differences in L-carnitine, GBB, TMAO and acylcarnitines in blood and brain.
Background
The apolipoprotein E (APOE) ε4 allele, involved in fatty acid (FA) metabolism, is a major genetic risk factor for Alzheimer's disease (AD). This study examined the influence of APOE genotypes on blood and brain markers of the L-carnitine system, necessary for fatty acid oxidation (FAO), and their collective influence on the clinical and pathological outcomes of AD.
Methods
L-carnitine, its metabolites γ-butyrobetaine (GBB) and trimethylamine-n-oxide (TMAO), and its esters (acylcarnitines) were analyzed in blood from predominantly White community/clinic-based individuals (n = 372) and plasma and brain (n = 79) from the Religious Order Study (ROS) using liquid chromatography tandem mass spectrometry (LC-MS/MS).
Findings
Relative to total blood acylcarnitines, levels of short chain acylcarnitines (SCAs) were higher whereas long chain acylcarnitines (LCAs) were lower in AD, which was observed preclinically in APOE ε4s. Plasma medium chain acylcarnitines (MCAs) were higher amongst cognitively healthy APOE ε2 carriers relative to other genotypes. Compared to their respective controls, elevated TMAO and lower L-carnitine and GBB were associated with AD clinical diagnosis and these differences were detected at pre-clinically among APOE ε4 carriers. Plasma and brain GBB, TMAO, and acylcarnitines were also associated with post-mortem brain amyloid, tau, and cerebrovascular pathologies.
Interpretation
Alterations of blood L-carnitine, GBB, TMAO and acylcarnitines occur early in clinical AD progression and are influenced by APOE genotype. These changes correlate with post-mortem brain AD and cerebrovascular pathologies. Additional studies are required to better understand the role of the FAO disturbances in AD