1 research outputs found
New Low-Toxicity Cholinium-Based Ionic Liquids with Perfluoroalkanoate Anions for Aqueous Biphasic System Implementation
This work explores
the widening of properties of cholinium-based
ionic liquids (ILs) through their combination with perfluoroalkanoate
anions so that higher number of aqueous biphasic systems (ABSs) containing
nontoxic cholinium-based ILs is available. For that purpose, six cholinium
perfluoroalkanoate ILs were synthesized and their cytotoxicity was
evaluated using three different animal cell lines, envisaging biotechnology
applications. Ternary phase equilibrium data for ABSs composed of
the cholinium perfluoroalkanoate, with fluoroalkyl chains from C<sub>2</sub> up to C<sub>7</sub>, using a strong salting out agent, K<sub>3</sub>PO<sub>4</sub>, were determined at 25 °C. The results
show the relevant role of the size of fluorinated alkyl chain length
in the anion since, contrary to other ABSs containing ILs with increasing
alkyl chain length in the anion, the ABSs with cholinium perfluoroalkanoates
present well-spaced solubility curves, allowing the conclusion that
these ABSs can be tuned by a proper choice of the IL. The phase splitting
mechanism was also disclosed through water activity measurements