2 research outputs found
Discovery of 7ā(Prolinolā<i>N</i>āyl)-2-phenylamino-thiazolo[5,4ā<i>d</i>]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A<sub>2A</sub> Adenosine Receptor: Prediction from Molecular Modeling
We describe the identification
of 7-(prolinol-<i>N</i>-yl)-2-phenylamino-thiazoloĀ[5,4-<i>d</i>]Āpyrimidines as
a novel chemotype of non-nucleoside partial agonists for the A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR). Molecular-modeling
indicated that the (<i>S</i>)-2-hydroxymethylene-pyrrolidine
could mimic the interactions of agonistsā ribose, suggesting
that this class of compounds could have agonistic properties. This
was confirmed by functional assays on the A<sub>2A</sub>AR, where
their efficacy could be associated with the presence of the 2-hydroxymethylene
moiety. Additionally, the best compound displays promising affinity,
selectivity profile, and physicochemical properties
Discovery of 7ā(Prolinolā<i>N</i>āyl)-2-phenylamino-thiazolo[5,4ā<i>d</i>]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A<sub>2A</sub> Adenosine Receptor: Prediction from Molecular Modeling
We describe the identification
of 7-(prolinol-<i>N</i>-yl)-2-phenylamino-thiazoloĀ[5,4-<i>d</i>]Āpyrimidines as
a novel chemotype of non-nucleoside partial agonists for the A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR). Molecular-modeling
indicated that the (<i>S</i>)-2-hydroxymethylene-pyrrolidine
could mimic the interactions of agonistsā ribose, suggesting
that this class of compounds could have agonistic properties. This
was confirmed by functional assays on the A<sub>2A</sub>AR, where
their efficacy could be associated with the presence of the 2-hydroxymethylene
moiety. Additionally, the best compound displays promising affinity,
selectivity profile, and physicochemical properties