Peaks of Otter Salamander (Plethodon hubrichti) Condition Declines along an Elevational Gradient

Undergraduate Basi

Consuming Linked Data within a Large Educational Organization

Large universities tend to spread their services across several departments to serve their substantial student base. It is very common for this to result in developing different systems, which end up in creating many disconnected data silos within the organization. Data isolation is one of the main bottlenecks that prevent unlocking the full potential behind exploiting such data, to provide a better experience at the level of application deployment and data analysis. The Open University is in the process of connecting their data silos by relying on the Linked Data principles within the LUCERO project. We discuss in this paper three use-cases through which we consume Linked Data produced at the Open University: (1) a student services use-case showing how we exploit data connections to deliver learning material related to courses through the university's main course information website; (2) a mobile course application that enables students to easily explore courses by subject, qualification or research topic; and (3) a Leanback TV service that provides students the ability to watch, with a degree of control, a set of podcasts grouped in different channels. Through these use cases, we highlight in this paper the advantages and effects of consuming Linked Data within an organization

The revolving door between hospital and community: extended-spectrum beta-lactamase-producing Escherichia coli in Dublin.

BACKGROUND: Escherichia coli that produce extended-spectrum beta-lactamases (ESBLs) are an increasing cause of healthcare-associated infection, and community healthcare facilities may be a reservoir for important epidemic clones. AIM: To characterize retrospectively and investigate the epidemiology of ESBL-producing E. coli collected in a Dublin hospital, during 2009 and 2010, and to investigate the dissemination of specific clones within hospital and community healthcare facilities. METHODS: Pulsed-field gel electrophoresis (PFGE) was used to determine the genetic relatedness of 100 ESBL-producing E. coli isolates. Phylogenetic groups were determined and the O25b-ST131 clone identified in the collection. The genetic data were correlated with antimicrobial susceptibility, clinical and demographic data to explore the epidemiology of specific clones. FINDINGS: Phylogenetic groups B2 (62%) and D (18%) were the most common and were associated with non-urinary isolates (P CONCLUSIONS: E. coli O25b-ST131 is largely responsible for ESBL-producing E. coli in LTCFs in Dublin. The distribution of ESBL-producing E. coli in our hospital and community highlights a \u27revolving door\u27 through which these resistant bacteria spread and disseminate

Embedding accessibility in research support and scholarly communication systems and processes: A Reflective Case Study.

In the context of the Public Sector Bodies (Websites and Mobile Applications) Accessibility Regulations (2018) this reflective case study examines the improvements we are making to accessibility across our research systems. We share our methodologies and break down the steps we are taking to embed inclusive practices.  We explore how these steps went and what we have learnt from the process. We are committed to future digital content accessibility in research and scholarly communication at the [Organisation name] and this project shows how it can be achieved using existing resources and be applied to other situations. &nbsp

Statin use and breast cancer survival: a nationwide cohort study in Scotland

BACKGROUND: Preclinical evidence suggests that statins could delay cancer progression. Previous epidemiological findings have been inconsistent and some have been limited by small sample sizes, as well as certain time-related biases. This study aimed to investigate whether breast cancer patients who were exposed to statins had reduced breast cancer-specific mortality. METHODS: We conducted a retrospective cohort study of 15,140 newly diagnosed invasive breast cancer patients diagnosed from 2009 to 2012 within the Scottish Cancer Registry. Dispensed medication usage was obtained from linkages to the Scottish Prescribing Information System and breast cancer-specific deaths were identified from National Records of Scotland Death Records. Using time-dependent Cox regression models, hazard ratios (HR) and 95 % confidence intervals (CI) were calculated for the association between post-diagnostic exposure to statins (including simvastatin) and breast cancer-specific mortality. Adjustments were made for a range of potential confounders including age at diagnosis, year of diagnosis, cancer stage, grade, cancer treatments received, comorbidities, socioeconomic status and use of aspirin. RESULTS: A total of 1,190 breast cancer-specific deaths occurred up to January 2015. Overall, after adjustment for potential confounders, there was no evidence of an association between statin use and breast cancer-specific death (adjusted HR 0.93, 95 % CI 0.77, 1.12). No significant associations were observed in dose–response analyses or in analysis of all-cause mortality. For simvastatin use specifically, a weak non-significant reduction in breast cancer-specific mortality was observed compared to non-users (adjusted HR 0.89, 95 % CI 0.73, 1.08). Statin use before diagnosis was weakly associated with a reduction in breast cancer-specific mortality (adjusted HR 0.85, 95 % CI 0.74, 0.98). CONCLUSION: Overall, we found little evidence of a protective association between post-diagnostic statin use and cancer-specific mortality in a large nation-wide cohort of breast cancer patients. These findings will help inform the decision whether to conduct randomised controlled trials of statins as an adjuvant treatment in breast cancer