Brain-to-brain (B2B) communication system overview.

<p>On the left, the BCI subsystem is shown schematically, including electrodes over the motor cortex and the EEG amplifier/transmitter wireless box in the cap. Motor imagery of the feet codes the bit value 0, of the hands codes bit value 1. On the right, the CBI system is illustrated, highlighting the role of coil orientation for encoding the two bit values. Communication between the BCI and CBI components is mediated by the internet.</p

View of emitter and receiver subjects with non-invasive devices supporting, respectively, the BCI based on EEG changes driven by motor imagery (left) and the CBI based on the reception of phosphenes elicited by a neuronavigated TMS (right) components of the B2B transmission system.

<p>The successfully transmitted code in the particular scenario shown is a ‘0’: the target and ball are at the bottom of the screen (correctly encoding a 0 through motor imagery of the feet) and the TMS coil is in the orientation not producing phosphenes for this particular participant (subject 2, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0105225#pone-0105225-g003" target="_blank">Figure 3</a>), with the handle pointing upwards.</p

Location and orientation of hot spot for phospene production overlaid on MRI image of the head of subject 2 (see Figure 2).

<p>The active direction producing phospenes is highlighted in orange (in red, the orthogonal direction not producing phosphenes).</p