2 research outputs found
Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand
A Pd-catalyzed amide-directed
enantioselective hydrocarbofunctionalization
of unactivated alkenes with C–H nucleophiles has been developed
using a chiral monodentate oxazoline (MOXin) ligand. Various indoles
react at C3 position with aminoquinoline-coupled 3-alkenamides to
give γ addition products in good to excellent yield and enantioselectivity.
This study represents an important advance of the development of chiral
monodentate oxazoline ligands, which have been underexplored for asymmetric
catalysis
Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand
A Pd-catalyzed amide-directed
enantioselective hydrocarbofunctionalization
of unactivated alkenes with C–H nucleophiles has been developed
using a chiral monodentate oxazoline (MOXin) ligand. Various indoles
react at C3 position with aminoquinoline-coupled 3-alkenamides to
give γ addition products in good to excellent yield and enantioselectivity.
This study represents an important advance of the development of chiral
monodentate oxazoline ligands, which have been underexplored for asymmetric
catalysis