Sequential Reactions of Trimethylsilyldiazomethane with 4‑Alkenyl Ketones and Aldehydes Catalyzed by Lewis Bases

A sequence of a carbonyl addition between 4-alkenyl ketones and aldehydes with trimethylsilyldiazomethane followed by a 1,3-Brook rearrangement and an intramolecular 1,3-dipolar cycloaddition was promoted by Lewis bases tetrabutylammonium triphenyldifluorosilicate (TBAT) or potassium <i>tert</i>-butoxide (KO-<i>t</i>-Bu). Through these concatenated bond-forming processes, a variety of novel bi- and tricyclic Δ¹-pyrazolines were synthesized

Sequential Reactions of Trimethylsilyldiazomethane with 4‑Alkenyl Ketones and Aldehydes Catalyzed by Lewis Bases

A sequence of a carbonyl addition between 4-alkenyl ketones and aldehydes with trimethylsilyldiazomethane followed by a 1,3-Brook rearrangement and an intramolecular 1,3-dipolar cycloaddition was promoted by Lewis bases tetrabutylammonium triphenyldifluorosilicate (TBAT) or potassium <i>tert</i>-butoxide (KO-<i>t</i>-Bu). Through these concatenated bond-forming processes, a variety of novel bi- and tricyclic Δ¹-pyrazolines were synthesized

Sequential Reactions of Trimethylsilyldiazomethane with 4‑Alkenyl Ketones and Aldehydes Catalyzed by Lewis Bases

A sequence of a carbonyl addition between 4-alkenyl ketones and aldehydes with trimethylsilyldiazomethane followed by a 1,3-Brook rearrangement and an intramolecular 1,3-dipolar cycloaddition was promoted by Lewis bases tetrabutylammonium triphenyldifluorosilicate (TBAT) or potassium <i>tert</i>-butoxide (KO-<i>t</i>-Bu). Through these concatenated bond-forming processes, a variety of novel bi- and tricyclic Δ¹-pyrazolines were synthesized

Sequential Reactions of Trimethylsilyldiazomethane with 4‑Alkenyl Ketones and Aldehydes Catalyzed by Lewis Bases

A sequence of a carbonyl addition between 4-alkenyl ketones and aldehydes with trimethylsilyldiazomethane followed by a 1,3-Brook rearrangement and an intramolecular 1,3-dipolar cycloaddition was promoted by Lewis bases tetrabutylammonium triphenyldifluorosilicate (TBAT) or potassium <i>tert</i>-butoxide (KO-<i>t</i>-Bu). Through these concatenated bond-forming processes, a variety of novel bi- and tricyclic Δ¹-pyrazolines were synthesized

Mechanically Linked Poly[2]rotaxanes Constructed via the Hierarchical Self-Assembly Strategy

Mechanically linked poly[2]­rotaxanes have been successfully constructed via the hierarchical self-assembly strategy. The integration of two noninterfering noncovalent recognition motifs facilitates chain extension of the B21C7-based [2]­rotaxane monomer, demonstrating the capabilities to form self-standing films with preferable transparency and softness

Datasheet2_Research topics and hotspot trends of lumbar spondylolisthesis: A text-mining study with machine learning.zip

ObjectivesThe study aimed to conduct a bibliometric analysis of publications concerning lumbar spondylolisthesis, as well as summarize its research topics and hotspot trends with machine-learning based text mining.MethodsThe data were extracted from the Web of Science Core Collection (WoSCC) database and then analyzed in Rstudio1.3.1 and CiteSpace5.8. Annual publication production and the top-20 productive authors over time were obtained. Additionally, top-20 productive journals and top-20 influential journals were compared by spine-subspecialty or not. Similarly, top-20 productive countries/regions and top-20 influential countries/regions were compared by they were developed countries/regions or not. The collaborative relationship among countries and institutions were presented. The main topics of lumbar spondylolisthesis were classified by Latent Dirichlet allocation (LDA) analysis, and the hotspot trends were indicated by keywords with strongest citation bursts.ResultsUp to 2021, a total number of 4,245 articles concerning lumbar spondylolisthesis were finally included for bibliometric analysis. Spine-subspecialty journals were found to be dominant in the productivity and the impact of the field, and SPINE, EUROPEAN SPINE JOURNAL and JOURNAL OF NEUROSURGERY-SPINE were the top-3 productive and the top-3 influential journals in this field. USA, Japan and China have contributed to over half of the publication productivity, but European countries seemed to publish more influential articles. It seemed that developed countries/regions tended to produce more articles and more influential articles, and international collaborations mainly occurred among USA, Europe and eastern Asia. Publications concerning surgical management was the major topic, followed by radiographic assessment and epidemiology for this field. Surgical management especially minimally invasive technique for lumbar spondylolisthesis were the recent hotspots over the past 5 years.ConclusionsThe study successfully summarized the productivity and impact of different entities, which should benefit the journal selection and pursuit of international collaboration for researcher who were interested in the field of lumbar spondylolisthesis. Additionally, the current study may encourage more researchers joining in the field and somewhat inform their research direction in the future.</p

Additional file 1 of Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations

Supplementary Material 1: Figure S1: The relationship between TMB and MSI. Figure S2: Mutation overview of collected samples. Figure S3: Pathway mutation differential analysis in high or nonhigh PD-L1 expression group. Figure S4: Pathway mutation differential analysis in high or low TMB value group. Figure S5: Distribution of mutations in the PIK3CA and PTEN genes. Table S1: Detailed information for each patient. Table S2: The gene list of AllNGS-Panel 639. Table S3: Association between TMB status and clinical features. Table S4: Differential analysis of mutations in signaling pathways related to EGFR-sensitive mutations or high PD-L1 expression. Table S5: Differential analysis of mutations in signaling pathways related to EGFR-sensitive mutations or TMB-

Additional file 1: Figure S1. of The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury

Prediction and ranking of the MMP cleavage sites. The CS-1 region of the fibronectin peptide sequence. The CS-1 sequence is present within the FN-CS1 splice variant. The arrows point to the P1 residues of the putative cleavage sites. The data suggest the presence of the multiple MMP cleavage sites in the CS-1 sequence including the cleavage site for MT1-MMP/MMP-14 (LPHP-NLH and GPEI-LDV)