Electron Density Reconstruction of Solar Coronal Mass Ejections Based on a Genetic Algorithm: Method and Application

We present a new method to reconstruct the three-dimensional electron density of coronal mass ejections (CMEs) based on a genetic algorithm, namely the genetic reconstruction method (GRM). GRM is first applied to model CMEs with different orientations and shapes. A set of analytic model CMEs from Gibson and Low is employed to produce synthetic CME images for GRM reconstruction. Model CMEs with longitudes of 0, 45, 90, 135, 180 degrees and latitudes of 0, 15, 30, 45 degrees are used to test the performance of GRM. The model CMEs are obscured with a simulated occulter of a coronagraph to determine the influence of CME brightness incompleteness. We add random noise to some synthetic CME images to test the performance of GRM. The CME reconstructions are carried out using synthetic data from Solar Terrestrial Relations Observatory (STEREO) A and B with a separation angle of 90 degrees and from STEREO A and the Solar and Heliospheric Observatory (SOHO) with a separation angle of 73 degrees. The Pearson correlation coefficient and the mean relative absolute deviation are calculated to analyze the similarities in brightness and electron density between the model and reconstructed CMEs. Comparisons based on the similarity analysis under various conditions stated above give us valuable insights into the advantages and limitations of GRM reconstruction. The method is then applied to real coronagraph data from STEREO A and B, and SOHO on 2013 September 30.Comment: 27 pages, 17 figures, 1 table. Published on Ap

Large-scale effective connectivity analysis reveals the existence of two mutual inhibitory systems in patients with major depression

It is posited that cognitive and affective dysfunction in patients with major depression disorder (MDD) may be caused by dysfunctional signal propagation in the brain. By leveraging dynamic causal modeling, we investigated large-scale directed signal propagation (effective connectivity) among distributed large-scale brain networks with 43 MDD patients and 56 healthy controls. The results revealed the existence of two mutual inhibitory systems: the anterior default mode network, auditory network, sensorimotor network, salience network and visual networks formed an “emotional” brain, while the posterior default mode network, central executive networks, cerebellum and dorsal attention network formed a “rational brain”. These two networks exhibited excitatory intra-system connectivity and inhibitory inter-system connectivity. Patients were characterized by potentiated intra-system connections within the “emotional/sensory brain”, as well as over-inhibition of the “rational brain” by the “emotional/sensory brain”. The hierarchical architecture of the large-scale effective connectivity networks was then analyzed using a PageRank algorithm which revealed a shift of the controlling role of the “rational brain” to the “emotional/sensory brain” in the patients. These findings inform basic organization of distributed large-scale brain networks and furnish a better characterization of the neural mechanisms of depression, which may facilitate effective treatment

Targeting collagen in tumor extracellular matrix as a novel targeted strategy in cancer immunotherapy

Collagen, the most abundant protein in mammal, is widely expressed in tissues and organs, as well as tumor extracellular matrix. Tumor collagen mainly accumulates in tumor stroma or beneath tumor blood vessel endothelium, and is exposed due to the fragmentary structure of tumor blood vessels. Through the blood vessels with enhanced permeability and retention (EPR) effect, collagen-binding macromolecules could easily bind to tumor collagen and accumulate within tumor, supporting tumor collagen to be a potential tumor-specific target. Recently, numerous studies have verified that targeting collagen within tumor extracellular matrix (TEM) would enhance the accumulation and retention of immunotherapy drugs at tumor, significantly improving their anti-tumor efficacy, as well as avoiding severe adverse effects. In this review, we would summarize the known collagen-binding domains (CBD) or proteins (CBP), their mechanism and application in tumor-targeting immunotherapy, and look forward to future development