Romantic relationships and adjustment problems in China: The moderating effect of classroom romantic context

Theoretical and empirical research has shown that adolescent romantic relationships are associated with a wide range of developmental outcomes, including adverse consequences. The present study used a hierarchical linear model to examine the moderating effect of classroom romantic context on the association between adolescent romantic relationships and adjustment problems. Data were collected from 4776 Chinese adolescents across 106 classes and from 47 schools. The participants' ages ranged from 12 to 18 years. The results indicated that romantic involvement and breakups were associated with adolescents' depressive symptoms and delinquent behaviors. Moreover, the association between breakups and depressive symptoms depended on the classroom romantic context. Specifically, we found that adolescents who experienced breakups showed fewer depressive symptoms in classrooms where romantic relationships were common among classmates than in those classrooms where romantic relationships were rare among classmates. The theoretical implications of these findings are discussed. (c) 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved

Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer

Abstract Background Lung cancer is a malignant tumour with the fastest increase in morbidity and mortality around the world. The clinical treatments available have significant side effects, thus it is desirable to identify alternative modalities to treat lung cancer. Shashen Maidong decoction (SMD) is a commonly used traditional Chinese medicine (TCM) formula for treating lung cancer in the clinic. While the key functional components (KFC) and the underlying mechanisms of SMD treating lung cancer are still unclear. Methods We propose a new integrated pharmacology model, which combines a novel node-importance calculation method and the contribution decision rate (CDR) model, to identify the KFC of SMD and to deduce their mechanisms in the treatment of lung cancer. Results The enriched effective Gene Ontology (GO) terms selected from our proposed node importance detection method could cover 97.66% of enriched GO terms of reference targets. After calculating CDR of active components in key functional network, the first 82 components covered 90.25% of the network information, which were defined as KFC. 82 KFC were subjected to functional analysis and experimental validation. 5–40 μM protocatechuic acid, 100–400 μM paeonol or caffeic acid exerted significant inhibitory activity on the proliferation of A549 cells. The results show that KFC play an important therapeutic role in the treatment of lung cancer by targeting Ras, AKT, IKK, Raf1, MEK, and NF-κB in the PI3K-Akt, MAPK, SCLC, and NSCLC signaling pathways active in lung cancer. Conclusions This study provides a methodological reference for the optimization and secondary development of TCM formulas. The strategy proposed in this study can be used to identify key compounds in the complex network and provides an operable test range for subsequent experimental verification, which greatly reduces the experimental workload

Romantic relationships and adjustment problems in China: The moderating effect of classroom romantic context

Theoretical and empirical research has shown that adolescent romantic relationships are associated with a wide range of developmental outcomes, including adverse consequences. The present study used a hierarchical linear model to examine the moderating effect of classroom romantic context on the association between adolescent romantic relationships and adjustment problems. Data were collected from 4776 Chinese adolescents across 106 classes and from 47 schools. The participants' ages ranged from 12 to 18 years. The results indicated that romantic involvement and breakups were associated with adolescents' depressive symptoms and delinquent behaviors. Moreover, the association between breakups and depressive symptoms depended on the classroom romantic context. Specifically, we found that adolescents who experienced breakups showed fewer depressive symptoms in classrooms where romantic relationships were common among classmates than in those classrooms where romantic relationships were rare among classmates. The theoretical implications of these findings are discussed. (c) 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved