18,708 research outputs found

    Vertex operator algebras and operads

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    Vertex operator algebras are mathematically rigorous objects corresponding to chiral algebras in conformal field theory. Operads are mathematical devices to describe operations, that is, nn-ary operations for all nn greater than or equal to 00, not just binary products. In this paper, a reformulation of the notion of vertex operator algebra in terms of operads is presented. This reformulation shows that the rich geometric structure revealed in the study of conformal field theory and the rich algebraic structure of the theory of vertex operator algebras share a precise common foundation in basic operations associated with a certain kind of (two-dimensional) ``complex'' geometric object, in the sense in which classical algebraic structures (groups, algebras, Lie algebras and the like) are always implicitly based on (one-dimensional) ``real'' geometric objects. In effect, the standard analogy between point-particle theory and string theory is being shown to manifest itself at a more fundamental mathematical level.Comment: 16 pages. Only the definitions of "partial operad" and of "rescaling group" have been improve

    A novel two-step recombinogenic engineering method for bacterial artificial chromosome manipulation

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    Scatteract: Automated extraction of data from scatter plots

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    Charts are an excellent way to convey patterns and trends in data, but they do not facilitate further modeling of the data or close inspection of individual data points. We present a fully automated system for extracting the numerical values of data points from images of scatter plots. We use deep learning techniques to identify the key components of the chart, and optical character recognition together with robust regression to map from pixels to the coordinate system of the chart. We focus on scatter plots with linear scales, which already have several interesting challenges. Previous work has done fully automatic extraction for other types of charts, but to our knowledge this is the first approach that is fully automatic for scatter plots. Our method performs well, achieving successful data extraction on 89% of the plots in our test set.Comment: Submitted to ECML PKDD 2017 proceedings, 16 page

    Live recombinant Salmonella oral vaccine against avian influenza viruses

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    Helicases as antiviral drug targets.

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    1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.published_or_final_versio

    A hybrid adaptive antenna array

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    Owing to the excessive demand on signal processing and space constraint, a full digital implementation of a large adaptive antenna array at millimeter wave frequencies is very challenging. Targeted at long range high data rate point-topoint link in the 70/80 GHz bands, a novel hybrid adaptive antenna array which consists of analogue subarrays followed by a digital beamformer is presented in this paper to overcome the digital implementation difficulty. Two subarray configurations, the interleaved subarray and the side-by-side subarray, are proposed, and two Doppler resilient adaptive angle-of-arrival estimation and beamforming algorithms, the differential beam tracking (DBT) and the differential beam search (DBS), are developed. Simulation results on the DBT and DBS performance are provided using a 64 element hybrid planar array of four 4 by 4 element subarrays with the two subarray configurations, respectively. Recursive mean square error (MSE) bounds of the developed algorithms are also analyzed and compared with simulated MSEs. © 2006 IEEE

    Determination of the functions of the putative metal-binding domain of the SCV helicase.

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    Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells

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    Single-stranded oligonucleotide (SSO)-mediated gene modification is a newly developed tool for site-specific gene repair in mammalian cells; however, the corrected cells always show G2/M arrest and cannot divide to form colonies. This phenomenon and the unclear mechanism seriously challenge the future application of this technique. In this study, we developed an efficient SSO-mediated DNA repair system based on double-stranded break (DSB) induction. We generated a mutant EGFP gene with insertions of 24 bp to 1.6 kb in length as a reporter integrated in mammalian cell lines. SSOs were successfully used to delete the insertion fragments upon DSB induction at a site near the insertion. We demonstrated that this process is dependent on the ATM/ATR pathway. Importantly, repaired cell clones were viable. Effects of deletion length, SSO length, strand bias, and SSO modification on gene repair frequency were also investigated. © 2008 Mary Ann Liebert, Inc.published_or_final_versio

    Treating phenotype as given: a simple resampling method for genome-wide association studies

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    Significance of genetic association to a marker has been traditionally evaluated through statistics that are standardized such that their null distributions conform to some known ones. Distributional assumptions are often required in this standardization procedure. Based on the observation that the phenotype remains the same regardless of the marker being investigated, we propose a simple statistic that does not need such standardization. We propose a resampling procedure to assess this statistic’s genome-wide significance. This method has been applied to replicate 2 of the Genetic Analysis Workshop 17 simulated data on unrelated individuals in an attempt to map phenotype Q2. However, none of the selected SNPs are in genes that are disease-causing. This may be due to the weak effect that each genetic factor has on Q2
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