Understanding Convolution for Semantic Segmentation

Recent advances in deep learning, especially deep convolutional neural networks (CNNs), have led to significant improvement over previous semantic segmentation systems. Here we show how to improve pixel-wise semantic segmentation by manipulating convolution-related operations that are of both theoretical and practical value. First, we design dense upsampling convolution (DUC) to generate pixel-level prediction, which is able to capture and decode more detailed information that is generally missing in bilinear upsampling. Second, we propose a hybrid dilated convolution (HDC) framework in the encoding phase. This framework 1) effectively enlarges the receptive fields (RF) of the network to aggregate global information; 2) alleviates what we call the "gridding issue" caused by the standard dilated convolution operation. We evaluate our approaches thoroughly on the Cityscapes dataset, and achieve a state-of-art result of 80.1% mIOU in the test set at the time of submission. We also have achieved state-of-the-art overall on the KITTI road estimation benchmark and the PASCAL VOC2012 segmentation task. Our source code can be found at https://github.com/TuSimple/TuSimple-DUC .Comment: WACV 2018. Updated acknowledgements. Source code: https://github.com/TuSimple/TuSimple-DU

Molecular docking via quantum approximate optimization algorithm

Molecular docking plays a pivotal role in drug discovery and precision medicine, enabling us to understand protein functions and advance novel therapeutics. Here, we introduce a potential alternative solution to this problem, the digitized-counterdiabatic quantum approximate optimization algorithm (DC-QAOA), which utilizes counterdiabatic driving and QAOA on a quantum computer. Our method was applied to analyze diverse biological systems, including the SARS-CoV-2 Mpro complex with PM-2-020B, the DPP-4 complex with piperidine fused imidazopyridine 34, and the HIV-1 gp120 complex with JP-III-048. The DC-QAOA exhibits superior performance, providing more accurate and biologically relevant docking results, especially for larger molecular docking problems. Moreover, QAOA-based algorithms demonstrate enhanced hardware compatibility in the noisy intermediate-scale quantum era, indicating their potential for efficient implementation under practical docking scenarios. Our findings underscore quantum computing's potential in drug discovery and offer valuable insights for optimizing protein-ligand docking processes.Comment: 10 pages, 5 figures, All comments are welcom

Quasi-Periodic Variations in X-ray Emission and Long-Term Radio Observations: Evidence for a Two-Component Jet in Sw J1644+57

The continued observations of Sw J1644+57 in X-ray and radio bands accumulated a rich data set to study the relativistic jet launched in this tidal disruption event. The X-ray light curve of Sw J1644+57 from 5-30 days presents two kinds of quasi-periodic variations: a 200 second quasi-periodic oscillation (QPO) and a 2.7-day quasi-periodic variation. The latter has been interpreted by a precessing jet launched near the Bardeen-Petterson radius of a warped disk. Here we suggest that the $\sim$ 200s QPO could be associated with a second, narrower jet sweeping the observer line-of-sight periodically, which is launched from a spinning black hole in the misaligned direction with respect to the black hole's angular momentum. In addition, we show that this two-component jet model can interpret the radio light curve of the event, especially the re-brightening feature starting $\sim 100$ days after the trigger. From the data we infer that inner jet may have a Lorentz factor of $\Gamma_{\rm j} \sim 5.5$ and a kinetic energy of $E_{\rm k,iso} \sim 3.0 \times 10^{52} {\rm erg}$, while the outer jet may have a Lorentz factor of $\Gamma_{\rm j} \sim 2.5$ and a kinetic energy of $E_{\rm k,iso} \sim 3.0 \times 10^{53} {\rm erg}$.Comment: 11 pages, 7 figures, accepted for publication in Ap