The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma

<p>Abstract</p> <p>Background</p> <p>To define a threshold value of apparent diffusion coefficient (ADC) with which malignant breast lesions can be distinguished from benign lesions, and to evaluate the ADC change of peri-tumor tissue in breast carcinoma by echo planar-diffusion weighted imaging (EPI-DWI).</p> <p>Methods</p> <p>57 breast lesions were scanned by routine MRI and EPI-DWI. The ADC values were compared between malignant and benign lesions. The sensitivity and specificity of EPI-DWI and the threshold ADC value were evaluated by Receiver Operating Characteristic curve (ROC). The ADC values of malignant lesion and layered peri-tumor tissues (from innermost layer 1 to outermost layer 4 with 5 mm every layer) in different directions were compared and the ADC values among different layers were compared.</p> <p>Results</p> <p>The ADC value of 35 malignant lesions was statistically lower than that of 22 benign lesions (P < 0.05). In ROC curve, the threshold value was 1.24 +/- 0.25*10E-3 mm²/s (b = 500) or 1.20 +/- 0.25*10E-3 mm²/s (b = 1000). The ADC value of malignant lesions was statistically lower than that of peri-tumor tissues in different directions (P < 0.05). For peri-tumor tissues, the ADC values increased gradually from layer 1 to layer 4 and there was a significant difference between the ADC values of layer 1 and layer 2 (P < 0.05); while from layer 2 outwards, there was no statistical difference among different layers.</p> <p>Conclusion</p> <p>ADC value was a sensitive and specific parameter that could help to differentiate benign and malignant breast lesions. ADC changes in tissues adjacent to breast carcinoma could be detected by EPI-DWI, which made EPI-DWI a promising method for helping to determine surgical scope of breast carcinoma.</p

Use of Praziquantel as an Adjuvant Enhances Protection and Tc-17 Responses to Killed H5N1 Virus Vaccine in Mice

BACKGROUND: H5N1 is a highly pathogenic influenza A virus, which can cause severe illness or even death in humans. Although the widely used killed vaccines are able to provide some protection against infection via neutralizing antibodies, cytotoxic T-lymphocyte responses that are thought to eradicate viral infections are lacking. METHODOLOGY/PRINCIPAL FINDINGS: Aiming to promote cytotoxic responses against H5N1 infection, we extended our previous finding that praziquantel (PZQ) can act as an adjuvant to induce IL-17-producing CD8(+) T cells (Tc17). We found that a single immunization of 57BL/6 mice with killed viral vaccine plus PZQ induced antigen-specific Tc17 cells, some of which also secreted IFN-γ. The induced Tc17 had cytolytic activities. Induction of these cells was impaired in CD8 knockout (KO) or IFN-γ KO mice, and was even lower in IL-17 KO mice. Importantly, the inoculation of killed vaccine with PZQ significantly reduced virus loads in the lung tissues and prolonged survival. Protection against H5N1 virus infection was obtained by adoptively transferring PZQ-primed wild type CD8(+) T cells and this was more effective than transfer of activated IFN-γ KO or IL-17 KO CD8(+) T cells. CONCLUSIONS/SIGNIFICANCE: Our results demonstrated that adding PZQ to killed H5N1 vaccine could promote broad Tc17-mediated cytotoxic T lymphocyte activity, resulting in improved control of highly pathogenic avian influenza virus infection

Conversion of a Pilot Boat to Operation on Methanol

There is currently a great need and interest in alternative fuels for shipping. Methanol is considered to be the most cost-effective alternative fuel for conversion of existing ships in order to reduce harmful emissions. There are now a number of project ongoing for conversion and new building of large vessels for methanol operation. Methanol can be produced from renewable raw materials, and will therefore be an attractive option for operators who want to/can/must prioritize this aspect. This includes for example operators of road ferries, boats for coast guard, pilot boats and boats public transport. The aim for this project was convert a pilot boat to operate on methanol. This will support the development towards reduced greenhouse gas emissions and sustainability. The report is mainly focused on the feasibility study of an identified pilot boat given by the Swedish Maritime Administration (Pilot boat 729). The report shows the methanol engine concepts, arrangement of the equipment, firefighting system and the model of the pilot boat with all the necessary conversion equipment

NMR spectroscopic and kinetic studies on secondary enamines of heterocyclic oximes hydrazones and semicarbazones

published_or_final_versionChemistryDoctoralDoctor of Philosoph

Editorial for the Special Issue on Advanced Materials, Structures and Processing Technologies Based on Pulsed Laser

Pulsed lasers are lasers with a single laser pulse width of less than 0 [...

Evolution Mechanism of Transient Strain and Residual Stress Distribution in Al 6061 Laser Welding

Considering the harm that residual stress causes to the mechanical properties of a weld joint, the evolution mechanisms of transient strain and residual stress distribution are investigated in laser welding of Al 6061, considering that these originate from non-uniform temperature distribution and are intensified further by the unbalanced procedure of melting and solidification. Thermal-elastic-plastic finite element method is developed and analyzed, while the actual weld profile is novel fitted by a B-spline curve. Transient strain is extracted by strain gauges. Longitudinal strain starts from a fluctuating compressive state and progresses to an ultimate residual tension state at the starting and ending welding positions, respectively. The maximum fitting deviation of the weld profile is 0.13 mm. Experimental and simulation results of residual strain are 842.0 μ and 826.8 μ, with a relative error of 1.805% at the starting position and −17.986% at the ending position. Near the weld center, mechanical behavior is complexly influenced by thermal expansion and contraction in the weld zone and the reaction binding force of the solid metal. Within a distance between −10 mm and 10 mm, and longitudinal stress is in a tension state, transverse stress fluctuates with a high gradient (~100 MPa)

PI Film Laser Micro-Cutting for Quantitative Manufacturing of Contact Spacer in Flexible Tactile Sensor

The contact spacer is the core component of flexible tactile sensors, and the performance of this sensor can be adjusted by adjusting contact spacer micro-hole size. At present, the contact spacer was mainly prepared by non-quantifiable processing technology (electrospinning, etc.), which directly leads to unstable performance of tactile sensors. In this paper, ultrathin polyimide (PI) contact spacer was fabricated using nanosecond ultraviolet (UV) laser. The quality evaluation system of laser micro-cutting was established based on roundness, diameter and heat affected zone (HAZ) of the micro-hole. Taking a three factors, five levels orthogonal experiment, the optimum laser cutting process was obtained (pulse repetition frequency 190 kHz, cutting speed 40 mm/s, and RNC 3). With the optimal process parameters, the minimum diameter was 24.3 ± 2.3 μm, and the minimum HAZ was 1.8 ± 1.1 μm. By analyzing the interaction process between nanosecond UV laser and PI film, the heating-carbonization mechanism was determined, and the influence of process parameters on the quality of micro-hole was discussed in detail in combination with this mechanism. It provides a new approach for the quantitative industrial fabrication of contact spacers in tactile sensors

Research on Arc Length Tracking Control Technology of Tube-Sheet Welding Based on Pulsed TIG

During tungsten inert gas welding process, arc length will change due to thermal deformation, uneven surface of workpiece and tungsten electrode loss. Considering the large fluctuation of arc length in all-position annular seam welding under the action of multi-variable coupling, a mathematical model of arc length and arc voltage was established in this paper, and an isolated and high frequency arc voltage acquisition circuit was designed. An improved sliding filtering algorithm was proposed, and after filtering the real-time arc voltage data, fuzzy control algorithm was used to realize the online tracking control of arc length in annular seam welding, in order to improve the reliability and stability of welding quality of tube-sheet. The experimental results show that the dynamic response time of the proposed arc length tracking compensation method is not more than 40 ms, and the arc length tracking deviation is less than 0.2 mm, which can fully meet the requerements of welding seam tracking of tube-sheet welding