Numerical Investigations on Wedge Control of Separation of a Missile from an Aircraft

To make the missile safely separate from the internal weapons bay, a wedge flow control device is mounted on the front of the bay to control the variation of flow during the separation. The numerical simulations of missile separation without and with wedge flow control device under different sizes are carried out. The flow fields of different separation processes are obtained and discussed; the aerodynamic parameters and trajectory parameters of missile of different cases are illustrated and compared. Results show that, the wedge flow control device can accelerate the missile separation and has the effect of regulating the angular motion of missile. The influence of the wedge height is stronger than that of its length on the center of gravity motion and angular motion of missile

Non-equispaced Fourier Neural Solvers for PDEs

Solving partial differential equations is difficult. Recently proposed neural resolution-invariant models, despite their effectiveness and efficiency, usually require equispaced spatial points of data. However, sampling in spatial domain is sometimes inevitably non-equispaced in real-world systems, limiting their applicability. In this paper, we propose a Non-equispaced Fourier PDE Solver (\textsc{NFS}) with adaptive interpolation on resampled equispaced points and a variant of Fourier Neural Operators as its components. Experimental results on complex PDEs demonstrate its advantages in accuracy and efficiency. Compared with the spatially-equispaced benchmark methods, it achieves superior performance with $42.85\%$ improvements on MAE, and is able to handle non-equispaced data with a tiny loss of accuracy. Besides, to our best knowledge, \textsc{NFS} is the first ML-based method with mesh invariant inference ability to successfully model turbulent flows in non-equispaced scenarios, with a minor deviation of the error on unseen spatial points.Comment: 27 page

A Deep Spatiotemporal Attention Network for Mild Cognitive Impairment Identification

Mild cognitive impairment (MCI) is a nervous system disease, and its clinical status can be used as an early warning of Alzheimer's disease (AD). Subtle and slow changes in brain structure between patients with MCI and normal controls (NCs) deprive them of effective diagnostic methods. Therefore, the identification of MCI is a challenging task. The current functional brain network (FBN) analysis to predict human brain tissue structure is a new method emerging in recent years, which provides sensitive and effective medical biomarkers for the diagnosis of neurological diseases. Therefore, to address this challenge, we propose a novel Deep Spatiotemporal Attention Network (DSTAN) framework for MCI recognition based on brain functional networks. Specifically, we first extract spatiotemporal features between brain functional signals and FBNs by designing a spatiotemporal convolution strategy (ST-CONV). Then, on this basis, we introduce a learned attention mechanism to further capture brain nodes strongly correlated with MCI. Finally, we fuse spatiotemporal features for MCI recognition. The entire network is trained in an end-to-end fashion. Extensive experiments show that our proposed method significantly outperforms current baselines and state-of-the-art methods, with a classification accuracy of 84.21%

Effect of potassium simplex optimization medium (KSOM) and embryo screening on the production of human lactoferrin transgenic cloned dairy goats

In this study, we produced cloned transgenic dairy goat based on dairy goat ear skin fibroblast as donor cells for nuclear transfer (NT), which were modified by human lactoferrin (hLF) gene. The developmental competence of NT embryos was compared with either between different embryo culture medium, potassium simplex optimization medium (KSOM) and tissue culture medium (TCM 199), or different classification of NT embryos (48 h after fusion). First we cultured NT embryos to cleavage stage (48 h after fusion) by TCM 199 supplemented with 1 mg/ml bovine serum albumin BSA and KSOM, then used TCM 199 supplemented with 10% FBS to culture them to blastula stage. The results show that the NT embryos in KSOM (19.5%) were superior to TCM 199 (10.6%) in blastulation. In the second experiment, we found that the growth rate of NT embryos (48 h after fusion) was different, then we divided them into four groups: 2-cell, 3- to 4-cell, 5- to 8-cell and >8-cell in stereo microscope and cultured them in vitro respectively. The results show day-2 embryos at 3-4cell and 5-8cell stage (31.9 and 28.2%, P < 0.05) had higher blastocyst formation rates than those at both 2-cell (9.1%) and >8-cell (8.3%) stage, and finally three healthy cloned transgenic goat were successfully produced using 3-8 cell embryos at Day-2 (82%). Using Hoechst 33342 staining, we also found that the >8 cells embryos at Day- 2 demonstrated higher frequency of fragmentation, which may be the one cause of the low blastocyst formation rate. This study therefore demonstrates that KSOM medium could be selected as the early embryo culture medium, and 3-8 cell embryos at day-2 (48 h after fusion) may be the suitable embryos for transplantation, which could reduce the nuclei fragmentation and result in good quality blastocysts that may also enhance the efficiency of transgenic cloned dairy goats production, as well as decrease the economic loss due to embryonic mortality when embryos are transferred to synchronized recipients.Key words: Nuclear transfer, KSOM, transgenic, human lactoferrin, dairy goat

Flexural Properties of ECC-Concrete Composite Beam

Rebar corrosion-induced durability issue is a major concern for bridges. The ECC cover was employed to prevent the intrusion of the corrosive agent. This paper studied the flexural behavior of ECC-concrete composite beam. The effects of bonding at the interface and fiber mesh reinforcement on the flexural properties and cracking pattern were investigated. The strain distribution and midspan deflection were evaluated. Test results show that the bonded composite beam had a higher loading capacity. But the unbonded composite beam showed better postcrack energy absorption capacity with higher midspan deflection. The fiber mesh reinforcement could further improve the flexural properties regardless of the bonding condition. The strain at the bottom of the unbonded beam was much smaller than that of the bonded beam. The penetrated cracks were observed at the ECC layer of the bonded composited beam

Gender minority stress and access to health care services among transgender women and transfeminine people: results from a cross-sectional study in China

Background Transgender and gender diverse individuals often face structural barriers to health care because of their gender minority status. The aim of this study was to examine the association between gender minority stress and access to specific health care services among transgender women and transfeminine people in China. Methods This multicenter cross-sectional study recruited participants between January 1st and June 30th 2020. Eligible participants were 18 years or older, assigned male at birth, not currently identifying as male, and living in China. Gender minority stress was measured using 45 items adapted from validated subscales. We examined access to health care services and interventions relevant to transgender and gender diverse people, including gender affirming interventions (hormones, surgeries), human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) testing, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP). Multivariable regression was used to measure correlations between gender minority stress and access to health care service. Results Three hundred and twenty-four people completed a survey and data from 277 (85.5%) people were analyzed. The mean age was 29 years old (standard deviation [SD] = 8). Participants used hormones (118/277, 42.6%), gender affirming surgery (26/277, 9.4%), HIV testing (220/277, 79.4%), STI testing (132/277, 47.7%), PrEP (24/276, 8.7%), and PEP (29/267, 10.9%). Using gender affirming hormones was associated with higher levels of discrimination (adjusted odds ratio [aOR] 1.41, 95% confidence interval [CI] 1.17-1.70) and internalized transphobia (aOR 1.06, 95%CI 1.00-1.12). STI testing was associated with lower levels of internalized transphobia (aOR 0.91, 95%CI 0.84-0.98). Conclusions Our data suggest that gender minority stress is closely related to using health services. Stigma reduction interventions and gender-affirming medical support are needed to improve transgender health