Organized Labor at the Crossroads

This group of essays offers a detailed look at the problems, choices and future of industrial relations.https://research.upjohn.org/up_press/1204/thumbnail.jp

Human Capital and Economic Development

Six essays are presented that explore human capital and its relationship to issues such as demographics, population growth, families, workplace training and economic progress.https://research.upjohn.org/up_press/1198/thumbnail.jp

Maternal Education, Linkages and Child Nutrition in the Long and Short-run: Evidence from the Ethiopia Demographic and Health Surveys

We used the 2000 and 2005 Ethiopian Demographic and Health Surveys to analyze the effect of maternal education and its pathways on chronic (long-run) and acute (short-run) malnutrition inEthiopia. The pathways examined in this study are socioeconomic status, maternal health-seeking behavior, maternal knowledge of health and family planning and reproductive behavior. We find that maternal education works through all except health-seeking behavior. We also find that maternal education and its pathways are more relevant and robust in explaining chronic than acute malnutrition. Socioeconomic status is the most important factor linking maternal education and child nutritional status. Although girls’ education is a high policy priority, it may take time before its direct and indirect impacts to materialize and substantially improve child health outcomes. Faster results would require direct interventions on key elements of socioeconomic status

Dragon versus Eagle: The Chinese Economy and U.S.-China Relations

This book contains a group of papers that examine the complex and evolving economic relationship between China and the United States.https://research.upjohn.org/up_press/1237/thumbnail.jp

The Political Economy of Good Governance

The contributors to this book capture several of the key dimensions of good governance, as well as what deleterious and negative consequences may arise in its absence. They draw analysis and solutions from diverse sectors such as economics, public administration, management, and political science, in order to treat some of the most pressing societal issues of our time. They connect the importance of education, health, climate change, and poverty to address the challenges of creating a world where more countries embrace good governance policies to benefit their peoples.https://research.upjohn.org/up_press/1252/thumbnail.jp

The Political Economy of Inequality: U.S. and Global Dimensions

The contributors to this book discuss a variety of forms of social inequality which include large gaps in accumulated assets, discrepancies in access to quality education, unstable family life, lack of access to banking services, poor employment prospects, lack of health care services, and underrepresentation for political and legal matters. Together, they show how these forms of inequality are interrelated with income inequality and that, taken together, they pose the risk for societal and political unrest should they be left unresolved.https://research.upjohn.org/up_press/1280/thumbnail.jp

The Impacts of China\u27s Rise on the Pacific and the World

This book provides the perspectives of a group of noted China experts on how China’s economic expansion and internal reforms are impacting its neighbors in the Pacific region as well as the United States and the rest of the world.https://research.upjohn.org/up_press/1267/thumbnail.jp

Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin

<p>Abstract</p> <p>Background</p> <p>We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells in a concentration-dependent manner.</p> <p>Methods</p> <p>To investigate the effect of PHI, a novel histone deacetylases inhibitor (HDACi), on demethylation and activation of transcription of <it>p15 </it>in acute lymphoid leukemia cell line Molt-4, and to further decipher the potential mechanism of demethylation, DNA sequencing and modified methylation specific PCR (MSP) were used to screen <it>p15</it>-M and <it>p15</it>-U mRNA after Molt-4 cells were treated with PHI, 5-Aza and TSA. DNA methyltransferase 1 (DNMT1), 3A (DNMT3A), 3B (DNMT3B) and <it>p15 </it>mRNA were measured by RT-PCR. P15 protein, acetylated histone H3 and histone H4 were detected by Western Blot.</p> <p>Results</p> <p>The gene <it>p15 </it>in Molt-4 cells was hypermethylated and inactive. Hypermethylation of gene <it>p15 </it>was attenuated and <it>p15 </it>gene was activated de novo after 5 days exposure to PHI in a concentration-dependent manner. DNMT1 and DNMT3B were inhibited by PHI (P < 0.05). Alteration of DNMT3A was not significant at those concentrations. Acetylated histone H3 and histone H4 were accumulated markedly after exposure to PHI.</p> <p>Conclusion</p> <p>PHI could induce both DNA demethylation and acetylated H3 and H4 accumulation in Molt-4 cells. Hypermethylation of gene <it>p15 </it>was reversed and <it>p15 </it>transcription could be reactivated de novo by PHI.</p