5 research outputs found
Multiscale simulations of growth-dominated SbTe phase-change material for non-volatile photonic applications
Chalcogenide phase-change materials (PCMs) are widely applied in electronic
and photonic applications, such as non-volatile memory and neuro-inspired
computing. Doped SbTe alloys are now gaining increasing attention for
on-chip photonic applications, due to their growth-driven crystallization
features. However, it remains unknown whether SbTe also forms a metastable
crystalline phase upon nanoseconds crystallization in devices, similar to the
case of nucleation-driven Ge-Sb-Te alloys. Here, we carry out ab initio
simulations to understand the changes in optical properties of amorphous
SbTe upon crystallization and post annealing. During the continuous
transformation process, changes in the dielectric function are highly
wavelength-dependent from the visible-light range towards the telecommunication
band. Our finite-difference time-domain simulations based on the ab initio
input reveal key differences in device output for color display and photonic
memory applications upon tellurium ordering. Our work serves as an example of
how multiscale simulations of materials can guide practical photonic
phase-change applications.Comment: 16 pages,8 figure
A Lumped-Parameter Equivalent Circuit Modeling for S-Shaped <i>I</i>–<i>V</i> Kinks of Organic Solar Cells
We propose an improved lumped-parameter equivalent circuit model to describe S-shaped I⁻V kinks observed from organic solar cells. Firstly, to predict the S-shaped I⁻V kinks accurately in both the first and fourth quadrants, a shunt resistor in parallel with extraction diode is added to our previous model. Secondly, based on the Newton⁻Raphson method, we derive a solution to our improved circuit. Thirdly, our solution is verified by the method of least squares and experiments. Finally, compared with our previous work, the improved circuit has higher accuracy in demonstrating S-shaped I⁻V kinks in the first and fourth quadrants. Such an improved model is suitable for circuit simulations of organic solar cells
Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression
Abstract Osteoarthritis (OA) is a common disease characterized by cartilage degradation. Growing evidence showed that glucose metabolism impacts joint homeostasis and an imbalance between glycolysis and oxidative phosphorylation (OXPHOS) may exacerbate OA progression, however, a definitive link is yet to be established. Here, we report that pyruvate metabolism and oxidative phosphorylation pathway is enriched in OA cartilage through gene set enrichment analysis (GSEA) and expression of Pyruvate Dehydrogenase Kinase 1 (PDK1), an enzyme that can phosphorylate Pyruvate Dehydrogenase (PDH), and inhibit pyruvate fluxes into the tricarboxylic acid (TCA) cycle and to OXPHOS, in articular cartilage is notably reduced through destabilization of medial meniscus (DMM). Moreover, by inhibiting PDK1, cartilage loss is markedly accelerated in DMM-induced OA through extracellular matrix (ECM) degradation and apoptosis of chondrocytes. These results indicate that PDK1 is involved in the progression of OA through accelerating cartilage matrix degradation and synovium inflammation to ameliorate cartilage degeneration