A Knowledge Management performance evaluation model based on fuzzy set theory

As the knowledge-based economy time comes, the core of business process is transforming financial intensive into technology intensive and knowledge intensive gradually. However, the value of knowledge itself can’t be measured easily. We must evaluate and investigate the performance of knowledge management through activities of knowledge management process. During the performance evaluation process, many uncertain factors must be considered. It is also involved ambiguity occurred by human subjective judgment. Therefore, a performance evaluation model of knowledge management is proposed in this paper by combining Fuzzy Delphi with Fuzzy AHP. Finally, a numerical example is given to demonstrate the procedure for the proposed method at the end of this paper

Application of AHP hierarchical analysis and KANO quality model to investigate the needs of eye drop users and the charm factor of the compliance aids design

Previous studies have indicated that many patients with eye diseases are not adherent to eyedrops due to the difficulty in administration. The purpose of using eyedrop compliance aids is to help patients who have difficulties in administering eyedrops. However, this method has not been well recognized and accepted. This study aimed to upgrade eyedrop compliance aids so that the adherence of eyedrop users could be improved. Among the research methods employed in this study, the analytic hierarchy process (AHP) helped in proposing the best function sequence of the device, and a questionnaire based on the Kano model helped understand the degree of satisfaction with the existing products, as well as discover the appealing factors of their functions and examine their functional relationships. Finally, the results of the two methods were discussed and compared, and the results were used to identify the basic appealing factors influencing consumer satisfaction as well as provide the element attributes and significant features to be weighed in the design of eyedrops. This study suggested that in the design of eyedrops, both the physical and psychological needs of users should be taken into consideration, and reference indexes for aids design that may effectively improve user adherence to eyedrops should be proposed

Instrumentation and Metrology for Single RNA Counting in Biological Complexes or Nanoparticles by a Single-Molecule Dual-View System

Limited by the spatial resolution of optical microscopy, direct detection or counting of single components in biological complexes or nanoparticles is challenging, especially for RNA, which is conformationally versatile and structurally flexible. We report here the assembly of a customized single-molecule dual-viewing total internal reflection fluorescence imaging system for direct counting of RNA building blocks. The RNA molecules were labeled with a single fluorophore by in vitro transcription in the presence of a fluorescent AMP. Precise calculation of identical or mixed pRNA building blocks of one, two, three, or six copies within the bacteriophage phi29 DNA packaging motor or other complexes was demonstrated by applying a photobleaching assay and evaluated by binomial distribution. The dual-viewing system for excitation and recording at different wavelengths simultaneously will enable the differentiation of different complexes with different labels or relative motion of each labeled component in motion machines

MicroRNA-23a promotes myelination in the central nervous system.

Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin

The study of nonstrange quark stars within a modified NJL model

In this work, we employ a modified Nambu-Jona-Lasinio (NJL) model with proper-time regularization to study the structure of nonstrange quark stars. Considering the physical meaning of the four-fermion interaction coupling constant $G$ in the conventional NJL model, we modify it by $G=G_1+G_2\langle\bar{\psi}\psi\rangle$ to highlight the feedback of quark propagator to gluon propagator. To study the dependence of the equation of state (EOS) on this modification as well as the vacuum pressure, we choose nine representative EOSs for comparison. As a result, we find that a smaller $G_1$ corresponds to a stiffer EOS, but at low energy densities, a higher vacuum pressure (i.e., a smaller bag constant) yields a softer one. Furthermore, the heaviest quark star obtained with the modified NJL model satisfies not only recent mass measurement of PSR J0740+6620, but also radius constraints from x-ray timing observations. The corresponding tidal deformability is also in agreement with GW170817.Comment: 8 pages, 9 figure

Antisideslip and Antirollover Safety Speed Controller Design for Vehicle on Curved Road

When the drivers cannot be aware of the existing of forthcoming curved roads and fail to regulate their safety speeds accordingly, sideslip or rollover may occur with high probability. The antisideslip and antirollover control of vehicle on curved road in automatic highway systems is studied. The safety speed warning system is set before entering the curved road firstly. The speed adhesion control is adopted to shorten the braking distance while decelerating and to guarantee the safety speed. The velocity controller when decelerating on the straight path and the posture controller when driving on curved road are designed, respectively, utilizing integral backstepping technology. Simulation results demonstrate that this control system is characterized by quick and precise tracking and global stability. Consequently, it is able to avoid the dangerous operating conditions, such as sideslip and rollover, and guarantee the safety and directional stability when driving on curved road