The Moderating Role of Organizational Culture in the Relationship between Power, Trust, and eSCMS Adoption Intention

Building on multiple theoretical perspectives, we examined how organizational culture moderates the relationship between power, trust, and a firm’s eSCMS adoption intention. We tested the hypotheses using survey data collected from senior executives in China. Our findings reveal that a target firm’s perceived mediated power would negatively impact its trust toward a dominant firm, while its perceived non-mediated power would positively affect its trust. Meanwhile, trust can positively influence the target firm’s eSCMS adoption intention. Further, an internally focused culture weakens the negative effects of mediated power on trust. Meanwhile, an externally focused culture weakens the positive relationships between non-mediated power and trust, and between trust and eSCMS adoption intention. The externally focused culture could weaken the negative relationship between mediated power and trust either. The theoretical contributions and managerial implications of the study are discussed

Case Report: Telitacicept in severe myasthenia gravis: a case study with multiple autoantibodies

Multi-antibody-positive myasthenia gravis (MG) presentations are relatively rare, often found in older patients, and generally predict a poor prognosis. We report a case of a female patient with generalized MG, testing positive for Titin antibodies (Titin-Ab), ryanodine receptor antibodies (RyR-Ab), and acetylcholine receptor antibodies (AChR-Ab), and resistant to acetylcholinesterase inhibitors. Following unsuccessful traditional therapies, she received Telitacicept, leading to significant improvements. This case underscores Telitacicept’s potential efficacy for similar patients and offers insights into the clinical characteristics of multi-antibody MG

Potent anti-tumor activity of telomerase-dependent and HSV-TK armed oncolytic adenovirus for non-small cell lung cancer in vitro and in vivo

<p>Abstract</p> <p>Background</p> <p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required. In this study we generated a novel 'suicide gene' armed oncolytic adenoviral vector and investigated its antitumor effect both in vitro and in vivo.</p> <p>Methods</p> <p>Since the up-regulated expression of human telomerase reverse transcriptase (hTERT) is a hallmark of alltypes of NSCLC, we chose hTERT promoter to transcriptionally control E1A gene expression to obtain adenoviral replication in NSCLC. In order to further enhance anti-tumor effect of this oncolytic adenoviral vector, we inserted a 'suicide gene' i.e. Herpes Simplex Virus Thymidine Kinase (HSV-TK) into oncolytic adenoviral vector to engineer a novel armed oncolytic adenoviral vector 'Ad.hTERT-E1A-TK'.</p> <p>Results</p> <p>Ad.hTERT-E1A-TK efficiently killed different types of tumor cells including two types of NSCLC cells <it>in vitro</it>, causing no damage to normal primary fibroblasts. Furthermore, Ad.hTERT-E1A-TK infection combined with administration of prodrug gancyclovir (GCV) resulted in more potent cytotoxicity on NSCLC cells, and synergistically suppressed human NSCLC tumor growth in nude mice.</p> <p>Conclusion</p> <p>The results from this study showed that Ad.hTERT-E1A-TK/GCV could be a potent but safe anti-tumor strategy for NSCLC biotherapy.</p

Preparation and properties of a washable flame-retardant coated fabric

In this study, a flame-retardant-coating (FRC) agent has been prepared using hydrophobic organic silicone-phosphorus-nitrogen flame retardant and acrylic emulsion. Polyester-cotton blend fabric (P/C) has been treated with FRC agent, and the finishing process, thermal decomposition, flame retardancy, washability, softness and other properties are studied. Results show that the treated fabrics are of good flame retardancy; LOI is up to 32%, thermal degradation rate reduces by 7.8 %/min and thermal damage reduces by 74%. Limiting oxygen index (LOI) is found to be 24.6% and 23.7% for 5 and 10 times washing. The fastness shows excellent washability

Advances in phytoplankton population ecology in the Pearl river estuary

Phytoplankton is an important primary producer of the estuarine ecosystem, which is essential for the biogeochemical cycle of water elements and nutrient transfer. The Pearl River estuary (PRE) is a dynamically complex estuary, and the environment of PRE is significantly impacted by anthropogenic activities, variation of phytoplankton community structure in the PRE are complex. This review aims to compare phytoplankton species, species diversity, and abundance variation characteristics from the 1980s and 2020s, evaluate the overall trend of phytoplankton in the PRE, and discuss the main environmental factors affecting phytoplankton growth in the PRE. The data from the past 40 years in PRE showed that the number of phytoplankton species significantly decreased (p &lt; 0.05). There was no significant difference in the abundance of phytoplankton at the 10-year scale, however, the fluctuation range of the abundance has increased. Under the conditions of a decreasing species number and no significant difference in abundance, the species diversity of phytoplankton showed a downward trend. In addition, the dominant phytoplankton species in the nearshore waters were relatively homogenous, and the abundance of phytoplankton in the nearshore waters was higher than that in the open waters, which suggested that human activities have a great influence. This review can form the basis for facilitating health management in the PRE ecosystem. Further, relevant guidelines can be developed and implemented for promoting the ecological health of the Guangdong-Hong Kong-Macao Greater Bay Area and ensuring its sustainable development

Improving solar water-splitting performance of LaTaON_{2} by bulk defect control and interface engineering

Particle-assembled photoanode films for solar water splitting are often subjected to serious electron-hole recombination, thus exhibiting low solar-to-hydrogen efficiency. The construction of efficient particle-assembled photoanode remains a challenge. Here, taking LaTaON_{2} particle-assembled photoanode as a model, bulk defect control and interface engineering were introduced to reduce the electron-hole recombination. As a result, the solar photocurrent of LaTaON_{2} achieves 2.1 mA cm^{-2} at 1.6 V_{RHE} after the modification of CoO_{x}, an order of magnitude greater than the previously-reported value of 0.15 mA cm^{-2}. This dramatic enhancement is mainly ascribed to increased bulk electrical conductivity, and less back reactions on the conductive substrates, as well as facilitated hole transfer to reaction sites. This study may provide guidelines for the construction of highly efficient particle-assembled photoanode films

Effect of APOE ɛ4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A 18F Florbetapir PET-CT Study

Mild cognitive impairment (MCI) is recognized as a predementia syndrome caused by multiple etiologies and nonmemory symptoms in MCI have recently gained increasing attention. However, the pattern of Aβ deposition and the effect of APOE (apolipoprotein E, APOE) ε4 on cognitive impairment in amnestic MCI (aMCI) and nonamnestic MCI (naMCI) patients has not been demonstrated. In this work, the amyloid-β (Aβ) load by [$^{18}$F]florbetapir PET imaging and cognitive performance is compared by comprehensive neuropsychological scales in participants with different MCI types or different APOE ε4 carriage status. According to the Aβ positivity and results of voxel-wise analysis, higher Aβ loads are observed in aMCI patients than naMCI patients, especially aMCI patients with APOE ε4. Additionally, it is observed that memory domain Z scores show a strong negative correlation with global florbetapir SUVR in the aMCI group (r = – 0.352, p < 0.001) but not in the naMCI group (r = –0.016, p = 0.924). Moreover, this correlation is independent of APOE e4 carriage status. This study aims to identify high-risk groups at an early stage of AD(Alzheimer's Disease, AD) through cognitive performance and APOE ε4 carrier status, which can be important for guiding clinical intervention trials

A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection

BackgroundCOVID-19 and sepsis represent formidable public health challenges, characterized by incompletely elucidated molecular mechanisms. Elucidating the interplay between COVID-19 and sepsis, particularly in geriatric patients suffering from sepsis-induced acute respiratory distress syndrome (ARDS), is of paramount importance for identifying potential therapeutic interventions to mitigate hospitalization and mortality risks.MethodsWe employed bioinformatics and systems biology approaches to identify hub genes, shared pathways, molecular biomarkers, and candidate therapeutics for managing sepsis and sepsis-induced ARDS in the context of COVID-19 infection, as well as co-existing or sequentially occurring infections. We corroborated these hub genes utilizing murine sepsis-ARDS models and blood samples derived from geriatric patients afflicted by sepsis-induced ARDS.ResultsOur investigation revealed 189 differentially expressed genes (DEGs) shared among COVID-19 and sepsis datasets. We constructed a protein-protein interaction network, unearthing pivotal hub genes and modules. Notably, nine hub genes displayed significant alterations and correlations with critical inflammatory mediators of pulmonary injury in murine septic lungs. Simultaneously, 12 displayed significant changes and correlations with a neutrophil-recruiting chemokine in geriatric patients with sepsis-induced ARDS. Of these, six hub genes (CD247, CD2, CD40LG, KLRB1, LCN2, RETN) showed significant alterations across COVID-19, sepsis, and geriatric sepsis-induced ARDS. Our single-cell RNA sequencing analysis of hub genes across diverse immune cell types furnished insights into disease pathogenesis. Functional analysis underscored the interconnection between sepsis/sepsis-ARDS and COVID-19, enabling us to pinpoint potential therapeutic targets, transcription factor-gene interactions, DEG-microRNA co-regulatory networks, and prospective drug and chemical compound interactions involving hub genes.ConclusionOur investigation offers potential therapeutic targets/biomarkers, sheds light on the immune response in geriatric patients with sepsis-induced ARDS, emphasizes the association between sepsis/sepsis-ARDS and COVID-19, and proposes prospective alternative pathways for targeted therapeutic interventions